-
1
-
-
0024317904
-
Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported
-
Evans DA, Funkenstein HH, Albert MS et al.: Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA 262(18), 2551-2556 (1989).
-
(1989)
JAMA
, vol.262
, Issue.18
, pp. 2551-2556
-
-
Evans, D.A.1
Funkenstein, H.H.2
Albert, M.S.3
-
2
-
-
0031695197
-
Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset
-
Brookmeyer R, Gray S, Kawas C: Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am. J. Public Health 88(9), 1337-1342 (1998).
-
(1998)
Am. J. Public Health
, vol.88
, Issue.9
, pp. 1337-1342
-
-
Brookmeyer, R.1
Gray, S.2
Kawas, C.3
-
3
-
-
65449161780
-
2009 Alzheimer's disease facts and fgures
-
Alzheimer's Association: 2009 Alzheimer's disease facts and fgures. Alzheimer's Dement. 5(3), 234-270 (2009).
-
(2009)
Alzheimer's Dement.
, vol.5
, Issue.3
, pp. 234-270
-
-
Association, A.1
-
4
-
-
50949110086
-
Effect of physical activity on cognitive function in older adults at risk for alzheimer disease: A randomized trial
-
Lautenschlager NT, Cox KL, Flicker L et al.: Effect of physical activity on cognitive function in older adults at risk for alzheimer disease: a randomized trial. JAMA 300(9), 1027-1037 (2008).
-
(2008)
JAMA
, vol.300
, Issue.9
, pp. 1027-1037
-
-
Lautenschlager, N.T.1
Cox, K.L.2
Flicker, L.3
-
5
-
-
0037097703
-
Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: A longitudinal study from the Kungsholmen project
-
Wang HX, Karp A, Winblad B, Fratiglioni L: Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: a longitudinal study from the Kungsholmen project. Am. J. Epidemiol. 155(12), 1081-1087 (2002).
-
(2002)
Am. J. Epidemiol.
, vol.155
, Issue.12
, pp. 1081-1087
-
-
Wang, H.X.1
Karp, A.2
Winblad, B.3
Fratiglioni, L.4
-
6
-
-
68849119553
-
Physical activity, diet, and risk of Alzheimer disease
-
Scarmeas N, Luchsinger JA, Schupf N et al.: Physical activity, diet, and risk of Alzheimer disease. JAMA 302(6), 627-637 (2009).
-
(2009)
JAMA
, vol.302
, Issue.6
, pp. 627-637
-
-
Scarmeas, N.1
Luchsinger, J.A.2
Schupf, N.3
-
7
-
-
58249089520
-
Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity
-
The Rotterdam Study
-
Haag MDM, Hofman A, Koudstaal PJ, Stricker BHC, Breteler MMB: Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study. J. Neurol. Neurosurg. Psychiatr. 80(1), 13-17 (2009).
-
(2009)
J. Neurol. Neurosurg. Psychiatr.
, vol.80
, Issue.1
, pp. 13-17
-
-
Haag, M.D.M.1
Hofman, A.2
Koudstaal, P.J.3
Stricker, B.H.C.4
Breteler, M.M.B.5
-
8
-
-
33646696167
-
Reducing the risk of dementia: Effcacy of long-term treatment of hypertension
-
Peila R, White LR, Masaki K, Petrovitch H, Launer LJ: Reducing the risk of dementia: effcacy of long-term treatment of hypertension. Stroke 37(5), 1165-1170 (2006).
-
(2006)
Stroke
, vol.37
, Issue.5
, pp. 1165-1170
-
-
Peila, R.1
White, L.R.2
Masaki, K.3
Petrovitch, H.4
Launer, L.J.5
-
9
-
-
46049108790
-
42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies
-
42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology 70, 2291-2298 (2008).
-
(2008)
Neurology
, vol.70
, pp. 2291-2298
-
-
Szekely, C.A.1
Green, R.C.2
Breitner, J.C.S.3
-
10
-
-
0346688728
-
Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: The Cache County Study
-
Zandi PP, Anthony JC, Khachaturian AS et al.: Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch. Neurol. 61(1), 82-88 (2004).
-
(2004)
Arch. Neurol.
, vol.61
, Issue.1
, pp. 82-88
-
-
Zandi, P.P.1
Anthony, J.C.2
Khachaturian, A.S.3
-
11
-
-
59849110667
-
List of drugs in development for neurodegenerative diseases, Update June 2008
-
Pogacic V, Herrling P: List of drugs in development for neurodegenerative diseases. Update June 2008. Neurodegener. Dis. 6(1-2), 37-86 (2009).
-
(2009)
Neurodegener. Dis.
, vol.6
, Issue.1-2
, pp. 37-86
-
-
Pogacic, V.1
Herrling, P.2
-
12
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y et al.: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375(6534), 754-760 (1995).
-
(1995)
Nature
, vol.375
, Issue.6534
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
-
13
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev EI, Sherrington R, Rogaeva EA et al.: Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376(6543), 775-778 (1995).
-
(1995)
Nature
, vol.376
, Issue.6543
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
-
14
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin MC, Mullan M et al.: Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349(6311), 704-706 (1991). (Pubitemid 21912142)
-
(1991)
Nature
, vol.349
, Issue.6311
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.-C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fldani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
Mant, R.11
Newton, P.12
Rooke, K.13
Roques, P.14
Talbot, C.15
Pericak-Vance, M.16
Roses, A.17
Williamson, R.18
Rossor, M.19
Owen, M.20
Hardy, J.21
more..
-
15
-
-
0027194791
-
Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder EH, Saunders AM, Strittmatter WJ et al.: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261(5123), 921-923 (1993).
-
(1993)
Science
, vol.261
, Issue.5123
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
-
16
-
-
33947223454
-
42 ratio as a prediction of cognitive decline in nondemented older adults
-
42 ratio as a prediction of cognitive decline in nondemented older adults. Arch. Neurol. 64(3), 343-349 (2007).
-
(2007)
Arch. Neurol.
, vol.64
, Issue.3
, pp. 343-349
-
-
Fagan, A.M.1
Roe, C.M.2
Xiong, C.3
Mintun, M.A.4
Morris, J.C.5
Holtzman, D.M.6
-
17
-
-
34547890294
-
42 ratio for increased risk of mild cognitive impairment: A follow-up study
-
42 ratio for increased risk of mild cognitive impairment: a follow-up study. Neurology 69(7), 631-639 (2007).
-
(2007)
Neurology
, vol.69
, Issue.7
, pp. 631-639
-
-
Li, G.1
Sokal, I.2
Quinn, J.F.3
-
18
-
-
67749122581
-
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease
-
Britschgi M, Olin CE, Johns HT et al.: Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Proc. Natl Acad. Sci. USA 106(29), 12145-12150 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, Issue.29
, pp. 12145-12150
-
-
Britschgi, M.1
Olin, C.E.2
Johns, H.T.3
-
19
-
-
63249120625
-
40 ratio in plasma during progression of Alzheimer's disease: A multicenter assessment
-
40 ratio in plasma during progression of Alzheimer's disease: a multicenter assessment. J. Nutr. Health Aging 13(3), 205-208 (2009).
-
(2009)
J. Nutr. Health Aging
, vol.13
, Issue.3
, pp. 205-208
-
-
Blennow, K.1
De Mg Hansson, O.2
-
20
-
-
60549103891
-
Blood protein signature for the early diagnosis of Alzheimer disease
-
Britschgi M, Wyss-Coray T: Blood protein signature for the early diagnosis of Alzheimer disease. Arch. Neurol. 66(2), 161-165 (2009).
-
(2009)
Arch. Neurol.
, vol.66
, Issue.2
, pp. 161-165
-
-
Britschgi, M.1
Wyss-Coray, T.2
-
21
-
-
70449435231
-
Identifying early markers of Alzheimer's disease using quantitative multiplex proteomic immunoassay panels
-
Soares HD, Chen Y, Sabbagh M, Rohrer A, Schrijvers E, Breteler M: Identifying early markers of Alzheimer's disease using quantitative multiplex proteomic immunoassay panels. Ann. NY Acad. Sci. 1180, 56-67 (2009).
-
(2009)
Ann. NY Acad. Sci.
, vol.1180
, pp. 56-67
-
-
Soares, H.D.1
Chen, Y.2
Sabbagh, M.3
Rohrer, A.4
Schrijvers, E.5
Breteler, M.6
-
22
-
-
33748371203
-
An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the infammatory signal bradykinin
-
Khan TK, Alkon DL: An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the infammatory signal bradykinin. Proc. Natl Acad. Sci. USA 103(35), 13203-13207 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, Issue.35
, pp. 13203-13207
-
-
Khan, T.K.1
Alkon, D.L.2
-
23
-
-
62349097513
-
Categorical and correlational analyses of baseline fuorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)
-
Langbaum JBS, Chen K, Lee W et al.: Categorical and correlational analyses of baseline fuorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Neuroimage 45, 1107-1116 (2009).
-
(2009)
Neuroimage
, vol.45
, pp. 1107-1116
-
-
Langbaum, J.B.S.1
Chen, K.2
Lee, W.3
-
24
-
-
0036235195
-
Longitudinal PET evaluation of cerebral metabolic decline in dementia: A potential outcome measure in Alzheimer's disease treatment studies
-
Alexander GE, Chen K, Pietrini P, Rapoport SI, Reiman EM: Longitudinal PET evaluation of cerebral metabolic decline in dementia: a potential outcome measure in Alzheimer's disease treatment studies. Am. J. Psychiatry 159(5), 738-745 (2002).
-
(2002)
Am. J. Psychiatry
, vol.159
, Issue.5
, pp. 738-745
-
-
Alexander, G.E.1
Chen, K.2
Pietrini, P.3
Rapoport, S.I.4
Reiman, E.M.5
-
25
-
-
77951685025
-
Brain imaging in the presymptomatic detection, tracking and prevention of Alzheimer's disease
-
Reiman EM: Brain imaging in the presymptomatic detection, tracking and prevention of Alzheimer's disease. Alzheimer's Dement. 5(4), 72 (2009).
-
(2009)
Alzheimer's Dement.
, vol.5
, Issue.4
, pp. 72
-
-
Reiman, E.M.1
-
26
-
-
70349977273
-
-
Imaging the Aging Brain. Jagust WJ, D'Esposito M (Eds) Oxford University Press, Oxford, UK
-
Reiman EM, Langbaum JBS: Brain imaging in the evaluation of putative Alzheimer's disease slowing, risk-reducing and prevention therapies. In: Imaging the Aging Brain. Jagust WJ, D'Esposito M (Eds). Oxford University Press, Oxford, UK 319-350 (2009).
-
(2009)
Brain Imaging in the Evaluation of Putative Alzheimer's Disease Slowing, Risk-reducing and Prevention Therapies
, pp. 319-350
-
-
Reiman, E.M.1
Langbaum, J.B.S.2
-
27
-
-
34250801552
-
Correlations between apolipoprotein e e4 gene dose and whole brain atrophy rates
-
Chen K, Reiman EM, Alexander GE et al.: Correlations between apolipoprotein E e4 gene dose and whole brain atrophy rates. Am. J. Psychiatry 164(6), 916-921 (2007).
-
(2007)
Am. J. Psychiatry
, vol.164
, Issue.6
, pp. 916-921
-
-
Chen, K.1
Reiman, E.M.2
Alexander, G.E.3
-
28
-
-
39749108812
-
11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment
-
Jack CR Jr, Lowe VJ, Senjem ML et al.: 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain 131(3), 665-680 (2008).
-
(2008)
Brain
, vol.131
, Issue.3
, pp. 665-680
-
-
Jack Jr., C.R.1
Lowe, V.J.2
Senjem, M.L.3
-
29
-
-
38149081191
-
18F-BAY94- 9172, a novel PET tracer: Proof of mechanism
-
18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol. 7(2) 129-135 (2008)
-
(2008)
Lancet Neurol.
, vol.7
, Issue.2
, pp. 129-135
-
-
Rowe, C.C.1
Ackerman, U.2
Browne, W.3
-
30
-
-
58149482094
-
Infuence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia
-
Small GW, Siddarth P, Burggren AC et al.: Infuence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia. Arch. Gen. Psychiatry 66(1), 81-87 (2009).
-
(2009)
Arch. Gen. Psychiatry
, vol.66
, Issue.1
, pp. 81-87
-
-
Small, G.W.1
Siddarth, P.2
Burggren, A.C.3
-
31
-
-
66149084048
-
Fibrillar amyloid-b burden in cognitively normal people at three levels of genetic risk for Alzheimer's disease
-
Reiman EM, Chen K, Liu X et al.: Fibrillar amyloid-b burden in cognitively normal people at three levels of genetic risk for Alzheimer's disease. Proc. Natl. Acad. Sci. USA 106(16), 6820-6825 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, Issue.16
, pp. 6820-6825
-
-
Reiman, E.M.1
Chen, K.2
Liu, X.3
-
32
-
-
43849083580
-
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
-
Ikonomovic MD, Klunk WE, Abrahamson EE et al.: Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain 131(6), 1630-1645 (2008).
-
(2008)
Brain
, vol.131
, Issue.6
, pp. 1630-1645
-
-
Ikonomovic, M.D.1
Klunk, W.E.2
Abrahamson, E.E.3
-
33
-
-
77951668620
-
-
Imaging the Aging Brain. Jagust WJ, D'Esposito M (Eds) Oxford University Press, Oxford, UK
-
Klunk WE, Mathis CA: Amyloid imaging and (what is 'normal'?) aging. In: Imaging the Aging Brain. Jagust WJ, D'Esposito M (Eds). Oxford University Press, Oxford, UK 191-244 (2009).
-
(2009)
Amyloid Imaging and (What Is 'Normal'?) Aging
, pp. 191-244
-
-
Klunk, W.E.1
Mathis, C.A.2
-
34
-
-
73549092137
-
Pittsburgh Compound-B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease
-
Morris JC, Roe CM, Grant EA et al.: Pittsburgh Compound-B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease. Arch. Neurol. 66(12), 1469-1475 (2009).
-
(2009)
Arch. Neurol.
, vol.66
, Issue.12
, pp. 1469-1475
-
-
Morris, J.C.1
Roe, C.M.2
Grant, E.A.3
-
35
-
-
34249984684
-
Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
-
Klunk WE, Price JC, Mathis CA et al.: Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees. J. Neurosci. 27(23), 6174-6184 (2007).
-
(2007)
J. Neurosci.
, vol.27
, Issue.23
, pp. 6174-6184
-
-
Klunk, W.E.1
Price, J.C.2
Mathis, C.A.3
-
36
-
-
33747048954
-
11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease
-
11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 67(3), 446-452 (2006).
-
(2006)
Neurology
, vol.67
, Issue.3
, pp. 446-452
-
-
Mintun, M.A.1
Larossa, G.N.2
Sheline, Y.I.3
-
37
-
-
70350716476
-
18F-AV-45: A PET agent for Ab plaques in the brain
-
18F-AV-45: a PET agent for Ab plaques in the brain. J. Nucl. Med. 50(11), 1887-1894 (2009).
-
(2009)
J. Nucl. Med.
, vol.50
, Issue.11
, pp. 1887-1894
-
-
Choi, S.R.1
Golding, G.2
Zhuang, Z.3
-
38
-
-
0037514257
-
1-42 and increased tau levels in cerebrospinal fuid of patients with Alzheimer disease
-
1-42 and increased tau levels in cerebrospinal fuid of patients with Alzheimer disease. JAMA 289(16), 2094-2103 (2003).
-
(2003)
JAMA
, vol.289
, Issue.16
, pp. 2094-2103
-
-
Sunderland, T.1
Linker, G.2
Mirza, N.3
-
40
-
-
20444395466
-
Correlations between apolipoprotein e e4 gene dose and brain-imaging measurements of regional hypometabolism
-
Reiman EM, Chen K, Alexander GE et al.: Correlations between apolipoprotein E e4 gene dose and brain-imaging measurements of regional hypometabolism. Proc. Natl Acad. Sci. USA 102(23), 8299-8302 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, Issue.23
, pp. 8299-8302
-
-
Reiman, E.M.1
Chen, K.2
Alexander, G.E.3
-
41
-
-
0035853154
-
Declining brain activity in cognitively normal apolipoprotein e e4 heterozygotes: A foundation for using positron emission tomography to effciently test treatments to prevent Alzheimer's disease
-
Reiman EM, Caselli RJ, Chen K, Alexander GE, Bandy D, Frost J: Declining brain activity in cognitively normal apolipoprotein E e4 heterozygotes: a foundation for using positron emission tomography to effciently test treatments to prevent Alzheimer's disease. Proc. Natl. Acad. Sci. USA 98(6), 3334-3339 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, Issue.6
, pp. 3334-3339
-
-
Reiman, E.M.1
Caselli, R.J.2
Chen, K.3
Alexander, G.E.4
Bandy, D.5
Frost, J.6
-
42
-
-
0347719366
-
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
-
Reiman EM, Chen K, Alexander GE et al.: Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia. Proc. Natl Acad. Sci. USA 101(1), 284-289 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, Issue.1
, pp. 284-289
-
-
Reiman, E.M.1
Chen, K.2
Alexander, G.E.3
-
43
-
-
0029970342
-
Preclinical evidence of Alzheimer's disease in persons homozygous for the e4 allele for apolipoprotein e
-
Reiman EM, Caselli RJ, Yun LS et al.: Preclinical evidence of Alzheimer's disease in persons homozygous for the e4 allele for apolipoprotein E. N. Engl. J. Med. 334(12), 752-758 (1996).
-
(1996)
N. Engl. J. Med.
, vol.334
, Issue.12
, pp. 752-758
-
-
Reiman, E.M.1
Caselli, R.J.2
Yun, L.S.3
-
44
-
-
40849111266
-
Cholesterol-related genetic risk scores are associated with hypometabolism in Alzheimer's-affected brain regions
-
Reiman EM, Chen K, Caselli RJ et al.: Cholesterol-related genetic risk scores are associated with hypometabolism in Alzheimer's-affected brain regions. Neuroimage 40(3), 1214-1221 (2008).
-
(2008)
Neuroimage
, vol.40
, Issue.3
, pp. 1214-1221
-
-
Reiman, E.M.1
Chen, K.2
Caselli, R.J.3
-
45
-
-
70349987633
-
Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal aging
-
Reiman EM, Chen K, Langbaum JB et al.: Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal aging. Neuroimage 49, 169-176 (2010).
-
(2010)
Neuroimage
, vol.49
, pp. 169-176
-
-
Reiman, E.M.1
Chen, K.2
Langbaum, J.B.3
-
46
-
-
33144484244
-
Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI)
-
Mueller SG, Weiner M W, Thal LJ et al.: Ways toward an early diagnosis in Alzheimer's disease: the Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimers Dement. 1(1), 55-66 (2005).
-
(2005)
Alzheimers Dement.
, vol.1
, Issue.1
, pp. 55-66
-
-
Mueller, S.G.1
Weiner, M.W.2
Thal, L.J.3
-
47
-
-
0034680078
-
Patterns of brain activation in people at risk for Alzheimer's disease
-
Bookheimer SY, Strojwas MH, Cohen MS et al.: Patterns of brain activation in people at risk for Alzheimer's disease. N. Engl. J. Med. 343(7), 450-456 (2000).
-
(2000)
N. Engl. J. Med.
, vol.343
, Issue.7
, pp. 450-456
-
-
Bookheimer, S.Y.1
Strojwas, M.H.2
Cohen, M.S.3
-
48
-
-
0028950856
-
Apolipoprotein e type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease
-
Small GW, Mazziotta JC, Collins MT et al.: Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. JAMA 273(12), 942-947 (1995).
-
(1995)
JAMA
, vol.273
, Issue.12
, pp. 942-947
-
-
Small, G.W.1
Mazziotta, J.C.2
Collins, M.T.3
-
49
-
-
44649190480
-
Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein e e4 carriers
-
Burggren AC, Zeineh MM, Ekstrom AD et al.: Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers. Neuroimage 41(4), 1177-1183 (2008).
-
(2008)
Neuroimage
, vol.41
, Issue.4
, pp. 1177-1183
-
-
Burggren, A.C.1
Zeineh, M.M.2
Ekstrom, A.D.3
-
50
-
-
38949110996
-
Accelerated age-related cortical thinning in healthy carriers of apolipoprotein e e4
-
Espeseth T, Westlye LT, Fjell AM, Walhovd KB, Rootwelt H, Reinvang I: Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E e4. Neurobiol. Aging 29(3), 329-340 (2008).
-
(2008)
Neurobiol. Aging
, vol.29
, Issue.3
, pp. 329-340
-
-
Espeseth, T.1
Westlye, L.T.2
Fjell, A.M.3
Walhovd, K.B.4
Rootwelt, H.5
Reinvang, I.6
-
51
-
-
66349129276
-
Distinct patterns of brain activity in young carriers of the APOE-e4 allele
-
Filippini N, Macintosh BJ, Hough MG et al.: Distinct patterns of brain activity in young carriers of the APOE-e4 allele. Proc. Natl Acad. Sci. USA 106(17), 7209-7214 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, Issue.17
, pp. 7209-7214
-
-
Filippini, N.1
MacIntosh, B.J.2
Hough, M.G.3
-
52
-
-
28944444529
-
Identifcation of Alzheimer disease risk by functional magnetic resonance imaging
-
Fleisher AS, Houston WS, Eyler LT et al.: Identifcation of Alzheimer disease risk by functional magnetic resonance imaging. Arch. Neurol. 62(12), 1881-1888 (2005).
-
(2005)
Arch. Neurol.
, vol.62
, Issue.12
, pp. 1881-1888
-
-
Fleisher, A.S.1
Houston, W.S.2
Eyler, L.T.3
-
53
-
-
34250163241
-
Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults
-
Jak AJ, Houston WS, Nagel BJ, Corey-Bloom J, Bondi MW: Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults. Dement. Geriatr. Cogn. Disord. 23(6), 382-389 (2007).
-
(2007)
Dement. Geriatr. Cogn. Disord.
, vol.23
, Issue.6
, pp. 382-389
-
-
Jak, A.J.1
Houston, W.S.2
Nagel, B.J.3
Corey-Bloom, J.4
Bondi, M.W.5
-
54
-
-
33745248702
-
The infuence of Alzheimer disease family history and apolipoprotein e e4 on mesial temporal lobe activation
-
Johnson SC, Schmitz TW, Trivedi MA et al.: The infuence of Alzheimer disease family history and apolipoprotein E e4 on mesial temporal lobe activation. J. Neurosci. 26(22), 6069-6076 (2006).
-
(2006)
J. Neurosci.
, vol.26
, Issue.22
, pp. 6069-6076
-
-
Johnson, S.C.1
Schmitz, T.W.2
Trivedi, M.A.3
-
55
-
-
33646239166
-
Reduced functional brain activity response in cognitively intact apolipoprotein e e4 carriers
-
Lind J, Persson J, Ingvar M et al.: Reduced functional brain activity response in cognitively intact apolipoprotein E e4 carriers. Brain 129(Pt 5), 1240-1248 (2006).
-
(2006)
Brain
, vol.129
, Issue.PART. 5
, pp. 1240-1248
-
-
Lind, J.1
Persson, J.2
Ingvar, M.3
-
56
-
-
0034641255
-
Longitudinal change in hippocampal volume as a function of apolipoprotein e genotype
-
Moffat SD, Szekely CA, Zonderman AB, Kabani NJ, Resnick SM: Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype. Neurology 55(1), 134-136 (2000).
-
(2000)
Neurology
, vol.55
, Issue.1
, pp. 134-136
-
-
Moffat, S.D.1
Szekely, C.A.2
Zonderman, A.B.3
Kabani, N.J.4
Resnick, S.M.5
-
57
-
-
39449093420
-
Hypometabolism and altered cerebrospinal fuid markers in normal apolipoprotein e e4 carriers with subjective memory complaints
-
Mosconi L, De SS, Brys M et al.: Hypometabolism and altered cerebrospinal fuid markers in normal apolipoprotein E e4 carriers with subjective memory complaints. Biol. Psychiatry 63(6), 609-618 (2008).
-
(2008)
Biol. Psychiatry
, vol.63
, Issue.6
, pp. 609-618
-
-
Mosconi, L.1
De Ss Brys, M.2
-
58
-
-
34248324435
-
Cortical morphology in children and adolescents with different apolipoprotein e gene polymorphisms: An observational study
-
Shaw P, Lerch JP, Pruessner JC et al.: Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study. Lancet Neurol. 6(6), 494-500 (2007).
-
(2007)
Lancet Neurol.
, vol.6
, Issue.6
, pp. 494-500
-
-
Shaw, P.1
Lerch, J.P.2
Pruessner, J.C.3
-
59
-
-
14944353045
-
A decade of pre-diagnostic assessment in a case of familial Alzheimer's disease: Tracking progression from asymptomatic to MCI and dementia
-
Godbolt AK, Cipolotti L, Anderson VM et al.: A decade of pre-diagnostic assessment in a case of familial Alzheimer's disease: tracking progression from asymptomatic to MCI and dementia. Neurocase 11(1), 56-64 (2005).
-
(2005)
Neurocase
, vol.11
, Issue.1
, pp. 56-64
-
-
Godbolt, A.K.1
Cipolotti, L.2
Anderson, V.M.3
-
60
-
-
33645894186
-
MRS shows abnormalities before symptoms in familial Alzheimer disease
-
Godbolt AK, Waldman AD, MacManus DG et al.: MRS shows abnormalities before symptoms in familial Alzheimer disease. Neurology 66(5), 718-722 (2006).
-
(2006)
Neurology
, vol.66
, Issue.5
, pp. 718-722
-
-
Godbolt, A.K.1
Waldman, A.D.2
MacManus, D.G.3
-
61
-
-
33750594921
-
Tracking atrophy progression in familial Alzheimer's disease: A serial MRI study
-
Ridha BH, Barnes J, Bartlett JW et al.: Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study. Lancet Neurol. 5(10), 828-834 (2006).
-
(2006)
Lancet Neurol.
, vol.5
, Issue.10
, pp. 828-834
-
-
Ridha, B.H.1
Barnes, J.2
Bartlett, J.W.3
-
62
-
-
0037308009
-
Assessing the onset of structural change in familial Alzheimer's disease
-
Schott JM, Fox NC, Frost C et al.: Assessing the onset of structural change in familial Alzheimer's disease. Ann. Neurol. 53(2), 181-188 (2003).
-
(2003)
Ann. Neurol.
, vol.53
, Issue.2
, pp. 181-188
-
-
Schott, J.M.1
Fox, N.C.2
Frost, C.3
-
63
-
-
0029969338
-
Atrophy of the hippocampal formation in early familial Alzheimer's disease. A longitudinal MRI study of at-risk members of a family with an amyloid precursor protein 717Val-Gly mutation
-
Fox NC, Warrington EK, Stevens JM, Rossor MN: Atrophy of the hippocampal formation in early familial Alzheimer's disease. A longitudinal MRI study of at-risk members of a family with an amyloid precursor protein 717Val-Gly mutation. Ann. NY Acad. Sci. 777, 226-232 (1996).
-
(1996)
Ann. NY Acad. Sci.
, vol.777
, pp. 226-232
-
-
Fox, N.C.1
Warrington, E.K.2
Stevens, J.M.3
Rossor, M.N.4
-
64
-
-
77951678168
-
Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation
-
In Press
-
Scholl M, Almkvist O, Axelman K et al.: Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation. Neurobiol. Aging (2009) (In Press).
-
(2009)
Neurobiol. Aging
-
-
Scholl, M.1
Almkvist, O.2
Axelman, K.3
-
65
-
-
33947261376
-
Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease
-
Mosconi L, Sorbi S, de Leon MJ et al.: Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease. J. Nucl. Med. 47(11), 1778-1786 (2006).
-
(2006)
J. Nucl. Med.
, vol.47
, Issue.11
, pp. 1778-1786
-
-
Mosconi, L.1
Sorbi, S.2
De Leon, M.J.3
-
66
-
-
0028796841
-
Defcits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease
-
Kennedy AM, Frackowiak RS, Newman SK et al.: Defcits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease. Neurosci. Lett. 186(1), 17-20 (1995).
-
(1995)
Neurosci. Lett.
, vol.186
, Issue.1
, pp. 17-20
-
-
Kennedy, A.M.1
Frackowiak, R.S.2
Newman, S.K.3
-
68
-
-
0035928402
-
Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
-
Fox NC, Crum WR, Scahill RI, Stevens JM, Janssen JC, Rossor MN: Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images. Lancet 358(9277), 201-205 (2001).
-
(2001)
Lancet
, vol.358
, Issue.9277
, pp. 201-205
-
-
Fox, N.C.1
Crum, W.R.2
Scahill, R.I.3
Stevens, J.M.4
Janssen, J.C.5
Rossor, M.N.6
-
69
-
-
0022242737
-
Brain metabolism as measured with positron emission tomography: Serial assessment in a patient with familial Alzheimer's disease
-
Cutler NR, Haxby JV, Duara R et al.: Brain metabolism as measured with positron emission tomography: serial assessment in a patient with familial Alzheimer's disease. Neurology 35(11), 1556-1561 (1985).
-
(1985)
Neurology
, vol.35
, Issue.11
, pp. 1556-1561
-
-
Cutler, N.R.1
Haxby, J.V.2
Duara, R.3
-
70
-
-
67650467011
-
Early structural changes in individuals at risk of familial Alzheimer's disease: A volumetry and magnetization transfer MR imaging study
-
Ginestroni A, Battaglini M, Della NR et al.: Early structural changes in individuals at risk of familial Alzheimer's disease: a volumetry and magnetization transfer MR imaging study. J. Neurol. 256(6), 925-932 (2009).
-
(2009)
J. Neurol.
, vol.256
, Issue.6
, pp. 925-932
-
-
Ginestroni, A.1
Battaglini Della M, N.R.2
-
71
-
-
0035849489
-
Presenilin-1-associated abnormalities in regional cerebral perfusion
-
Johnson KA, Lopera F, Jones K et al.: Presenilin-1-associated abnormalities in regional cerebral perfusion. Neurology 56(11), 1545-1551 (2001).
-
(2001)
Neurology
, vol.56
, Issue.11
, pp. 1545-1551
-
-
Johnson, K.A.1
Lopera, F.2
Jones, K.3
-
72
-
-
7444271086
-
1-42 and tau in control subjects at risk for Alzheimer's disease: The effect of APOE e4 allele
-
1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE e4 allele. Biol. Psychiatry 56(9), 670-676 (2004).
-
(2004)
Biol. Psychiatry
, vol.56
, Issue.9
, pp. 670-676
-
-
Sunderland, T.1
Mirza, N.2
Putnam, K.T.3
-
73
-
-
62349135758
-
The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease
-
Glodzik-Sobanska L, Pirraglia E, Brys M et al.: The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease. Neurobiol. Aging 30(5), 672-681 (2009).
-
(2009)
Neurobiol. Aging
, vol.30
, Issue.5
, pp. 672-681
-
-
Glodzik-Sobanska, L.1
Pirraglia, E.2
Brys, M.3
-
74
-
-
32544435900
-
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study
-
Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L: Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol. 5(3), 228-234 (2006).
-
(2006)
Lancet Neurol.
, vol.5
, Issue.3
, pp. 228-234
-
-
Hansson, O.1
Zetterberg, H.2
Buchhave, P.3
Londos, E.4
Blennow, K.5
Minthon, L.6
-
75
-
-
47549107705
-
Cognitive function over time in the Alzheimer's Disease Anti-infammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
-
ADAPT Research Group: Cognitive function over time in the Alzheimer's Disease Anti-infammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch. Neurol. 65(7), 896-905 (2008).
-
(2008)
Arch. Neurol.
, vol.65
, Issue.7
, pp. 896-905
-
-
Research Group, A.1
-
76
-
-
33646205347
-
The Ginkgo Evaluation of Memory (GEM) study: Design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia
-
DeKosky ST, Fitzpatrick A, Ives DG et al.: The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia. Contemp. Clin. Trials 27(3), 238-253 (2006).
-
(2006)
Contemp. Clin. Trials
, vol.27
, Issue.3
, pp. 238-253
-
-
Dekosky, S.T.1
Fitzpatrick, A.2
Ives, D.G.3
-
77
-
-
0038386058
-
Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: The Women's Health Initiative Memory Study: A randomized controlled trial
-
Shumaker SA, Legault C, Rapp SR et al.: Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA. 289(20), 2651-2662 (2003).
-
(2003)
JAMA
, vol.289
, Issue.20
, pp. 2651-2662
-
-
Shumaker, S.A.1
Legault, C.2
Rapp, S.R.3
-
78
-
-
2942755831
-
Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study
-
Shumaker SA, Legault C, Kuller L et al.: Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA. 291(24), 2947-2958 (2004).
-
(2004)
JAMA
, vol.291
, Issue.24
, pp. 2947-2958
-
-
Shumaker, S.A.1
Legault, C.2
Kuller, L.3
-
79
-
-
0030268577
-
Surrogate end points in clinical trials: Are we being misled?
-
Fleming TR, DeMets DL: Surrogate end points in clinical trials: are we being misled? Ann. Intern. Med. 125(7), 605-613 (1996).
-
(1996)
Ann. Intern. Med.
, vol.125
, Issue.7
, pp. 605-613
-
-
Fleming, T.R.1
Demets, D.L.2
-
80
-
-
23244451582
-
Biomarkers and surrogate markers: An FDA perspective
-
Katz R: Biomarkers and surrogate markers: an FDA perspective. NeuroRx 1(2), 189-195 (2004).
-
(2004)
NeuroRx
, vol.1
, Issue.2
, pp. 189-195
-
-
Katz, R.1
-
81
-
-
18144415471
-
Effects of Ab immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
-
Fox NC, Black RS, Gilman S et al.: Effects of Ab immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology 64(9), 1563-1572 (2005).
-
(2005)
Neurology
, vol.64
, Issue.9
, pp. 1563-1572
-
-
Fox, N.C.1
Black, R.S.2
Gilman, S.3
-
82
-
-
43649096329
-
A roadmap for the prevention of dementia: The inaugural Leon Thal Symposium
-
Khachaturian ZS, Petersen RC, Gauthier S et al.: A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimer's Dement. 4(3), 156-163 (2008).
-
(2008)
Alzheimer's Dement.
, vol.4
, Issue.3
, pp. 156-163
-
-
Khachaturian, Z.S.1
Petersen, R.C.2
Gauthier, S.3
-
83
-
-
62849108419
-
Prevent Alzheimer's disease by 2020: A national strategic goal
-
Khachaturian ZS, Khachaturian AS: Prevent Alzheimer's disease by 2020: a national strategic goal. Alzheimer's Dement. 5(2), 81-84 (2009).
-
(2009)
Alzheimer's Dement.
, vol.5
, Issue.2
, pp. 81-84
-
-
Khachaturian, Z.S.1
Khachaturian, A.S.2
-
84
-
-
43649102195
-
"A roadmap for the prevention of dementia: The inaugural Leon Thal Symposium." An impending prevention clinical trial for Alzheimer's disease: Roadmaps and realities
-
Roses AD: Commentary on "A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." An impending prevention clinical trial for Alzheimer's disease: roadmaps and realities. Alzheimer's Dement. 4(3), 164-166 (2008).
-
(2008)
Alzheimer's Dement.
, vol.4
, Issue.3
, pp. 164-166
-
-
Roses, A.D.1
On, C.2
-
85
-
-
43649085939
-
A roadmap for the prevention of dementia: The inaugural Leon Thal Symposium
-
Siemers ER, Paul SM: Commentary on "A roadmap for the prevention of dementia: The inaugural Leon Thal Symposium". Alzheimer's Dement. 4(3), 171-173 (2008).
-
(2008)
Alzheimer's Dement.
, vol.4
, Issue.3
, pp. 171-173
-
-
Siemers, E.R.1
Paul, S.M.2
On, C.3
-
86
-
-
0027425211
-
The Clinical Dementia Rating (CDR): Current version and scoring rules
-
Morris JC: The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43(11), 2412-2414 (1993).
-
(1993)
Neurology
, vol.43
, Issue.11
, pp. 2412-2414
-
-
Morris, J.C.1
|