Serotonin Syndrome Precipitated by Fentanyl During Procedural Sedation

Journal of Emergency Medicine

Volumn 38, Issue 4, 2010, Pages 477-480

  Kirschner, Ron ^a   Donovan, J Ward ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

drug interaction; fentanyl; procedural sedation; serotonin syndrome; serotonin toxicity

Indexed keywords

ESCITALOPRAM; FENTANYL; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TRAZODONE;

ABNORMAL LABORATORY RESULT; ADULT; AGITATION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ARTIFICIAL VENTILATION; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CASE REPORT; CLINICAL FEATURE; CLONUS; DELIRIUM; DIAPHORESIS; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DISEASE SEVERITY; DRUG POTENTIATION; FEMALE; HUMAN; PRIORITY JOURNAL; SEDATION; SEROTONIN SYNDROME; SIDE EFFECT; WITHDRAWAL SYNDROME;

CONSCIOUS SEDATION; EMERGENCY SERVICE, HOSPITAL; FEMALE; FENTANYL; HUMANS; HYPNOTICS AND SEDATIVES; MIDDLE AGED; PATIENT TRANSFER; RESPIRATION, ARTIFICIAL; SEROTONIN SYNDROME;

EID: 77951667773     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2008.01.003     Document Type: Article

References (19)

1. Egan T.D., Sharma A., Ashburn M.A., Kievit J., Pace N.L., and Streisand J.B. Multiple dose pharmacokinetics of oral transmucosal fentanyl citrate in healthy volunteers. Anesthesiology 92 (2000) 665-673
2. Rosow C.E., Moss J., Philbin D.M., and Savarese J.J. Histamine release during morphine and fentanyl anesthesia. Anesthesiology 56 (1982) 93-96
3. Fahnenstich H., Steffan J., Kau N., and Bartmann P. Fentanyl-induced chest wall rigidity and laryngospasm in preterm and term infants. Crit Care Med 28 (2000) 836-839
4. Gillman P.K. Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. Br J Anaesth 95 (2005) 434-441
5. Giese S.Y., and Neborsky R. Serotonin syndrome: potential consequences of Meridia combined with Demerol or fentanyl. Plast Reconstr Surg 107 (2001) 293-294
6. Isbister G.K., Buckley N.A., and Whyte I.M. Serotonin toxicity: a practical approach to diagnosis and treatment. Med J Aust 187 (2007) 361-365
7. Mills K.C. Serotonin syndrome. In: Brent J., Wallace K., Burkhart K., Phillips S., and Donovan J. (Eds). Critical care toxicology: diagnosis and management of the critically poisoned patient (2005), Elsevier Mosby, Philadelphia 281-290
8. Isbister G.K., and Buckley N.A. The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatment. Clin Neuropharmacol 28 (2005) 205-214
9. Sternbach H. The serotonin syndrome. Am J Psychiatry 148 (1991) 705-713
10. Dunkley E.J., Isbister G.K., Sibbritt D., Dawson A.H., and Whyte I.M. The Hunter Serotonin Toxicity Criteria: simple accurate diagnostic decision rules for serotonin toxicity. QJM 96 (2003) 635-642
11. Ailawadhi S., Sung K.W., Carlson L.A., and Baer M.R. Serotonin syndrome caused by interaction between citalopram and fentanyl. J Clin Pharm Ther 32 (2007) 199-202
12. Naranjo C.A., Busto U., Sellers E.M., et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30 (1981) 239-245
13. Tao R., Karnik M., Ma Z., and Auerbach S.B. Effects of fentanyl on 5-HT efflux involves both opioid and 5-HT1A receptors. Br J Pharmacol 139 (2003) 1498-1504
14. Roy S., and Fortier L.-P. Fentanyl-induced rigidity during emergence from general anesthesia potentiated by venlafaxine. Can J Anaesth 50 (2003) 32-35
15. Steurenburg H.J., Claassen J., Eggers C., and Hansen H.C. Acute adverse reaction to fentanyl in a 55 year old man. J Neurol Neurosurg Psychiatry 69 (2000) 281-282
16. Streisand J.B., Bailey P.L., LeMaire L., et al. Fentanyl-induced rigidity and unconsciousness in human volunteers. Anesthesiology 78 (1993) 629-634
17. Weinger M.B., Cline E.J., Smith N.T., and Koob G.F. Ketanserin pretreatment reverses alfentanil-induced muscle rigidity. Anesthesiology 67 (1987) 348-354
18. Jin M., Gock S.B., Jannetto P.J., Jentzen J.M., and Wong S.H. Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases. J Anal Toxicol 29 (2005) 590-598
19. Murphy Jr. G.M., Kremer C., Rodrigues H.E., and Schatzberg A.F. Pharmacogenetics of antidepressant medication intolerance. Am J Psychiatry 160 (2003) 1830-1835