Multiple dose pharmacokinetics of oral transmucosal fentanyl citrate in healthy volunteers

Anesthesiology

Volumn 92, Issue 3, 2000, Pages 665-673

  Egan, Talmage D ^a   Sharma, Amarnath ^b   Ashburn, Michael A ^a   Kievit, Jur ^a   Pace, Nathan L ^a   Streisand, James B ^c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GENZYME CORPORATION   (United States)

Author keywords

Nonintravenous; Opioid; Pharmacologic modeling

Indexed keywords

FENTANYL CITRATE;

ADULT; ANALGESIA; ARTERIAL BLOOD; ARTICLE; CANCER PAIN; CLINICAL ARTICLE; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; FEMALE; HUMAN; MALE; MODEL; MOUTH MUCOSA; PRIORITY JOURNAL;

EID: 0034050328     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200003000-00009     Document Type: Article

References (15)

1. Schechter NL, Weisman SJ, Rosenblum M, Bernstein B, Conard PL: The use of oral transmucosal fentanyl citrate for painful procedures in children. Pediatrics 1995; 95:335-9
2. Schutzman SA, Burg J, Liebelt E, Strafford M, Schechter N, Wisk M, Fleisher G: Oral transmucosal fentanyl citrate for premedication of children undergoing laceration repair. Ann Emerg Med 1994; 24:1059-64
3. Streisand JB, Varvel JR, Stanski DR, Le Maire L, Ashburn MA, Hague BI, Tarver SD, Stanley TH: Absorption and bioavailability of oral transmucosal fentanyl citrate. ANESTHESIOLOGY 1991; 75:223-9
4. Mather LE: Clinical pharmacokinetics of fentanyl and its newer derivatives. Clin Pharmacokinet 1983; 8:422-46
5. Schuttler J, White PF: Optimization of the radioimmunoassays for measuring fentanyl and alfentanil in human serum. ANESTHESIOLOGY 1984; 61:315-20
6. Beal SL, Sheiner LB: NONMEM User's Guide. San Francisco, University of California, 1979
7. Hudson RJ, Thomson IR, Cannon JE, Friesen RM, Meatherall RC: Pharmacokinetics of fentanyl in patients undergoing abdominal aortic surgery. ANESTHESIOLOGY 1986; 64:334-8
8. Sheiner LB, Ludden TM: Population pharmacokinetics/dynamics. Annu Rev Pharmacol Toxicol 1992; 32:185-209
9. D'Argenio DZ, Schumitzky A: ADAPT II: Pharmacokinetic/Pharmacodynamic Systems Analysis Software. User's Guide to Release 4. Los Angeles, University of Southern California, 1997
10. Notari RE, DeYoung JL, Reuning RH: Effect of parallel first-order loss from site of administration on calculated values for absorption rate constants. J Pharm Sci 1972; 61:135-8
11. Sahajwalla CG, Ayres JW: Multiple-dose acetaminophen pharmacokinetics. J Pharm Sci 1991; 80:855-60
12. Cilla DD Jr, Whitfield LR, Gibson DM, Sedman AJ, Posvar EL: Multiple-dose pharmacokinetics, pharmacodynamics, and safety of atorvastatin, an inhibitor of HMG-CoA reductase, in healthy subjects. Clin Pharmacol Ther 1996; 60:687-95
13. Portenoy RK, Southam MA, Gupta SK, Lapin J, Layman M, Inturrisi CE, Foley KM: Transdermal fentanyl for cancer pain: Repeated dose pharmacokinetics. ANESTHESIOLOGY 1993; 78:36-43
14. Streisand JB, Busch MA, Egan TD, Smith BG, Gay M, Pace NL: Dose proportionality and pharmacokinetics of oral transmucosal fentanyl citrate. ANESTHESIOLOGY 1998; 88:305-9
15. Gourlay GK, Kowalski SR, Plummer JL, Cousins MJ, Armstrong PJ: Fentanyl blood concentration-analgesic response relationship in the treatment of postoperative pain. Anesth Analg 1988; 67:329-37