Cyanide Poisoning and Cardiac Disorders: 161 Cases

Journal of Emergency Medicine

Volumn 38, Issue 4, 2010, Pages 467-476

  Fortin, Jean Luc ^a   Desmettre, Thibault ^a   Manzon, Cyril ^a   Judic Peureux, Virginie ^a   Peugeot Mortier, Caroline ^a   Giocanti, Jean Pascal ^a   Hachelaf, Mohamed ^a   Grangeon, Marie ^a   Hostalek, Ulrike ^b   Crouzet, Julien ^a   Capellier, Gilles ^a  

^a UNIVERSITY HOSPITAL JEAN MINJOZ   (France)

^b MERCK KGAA   (Germany)

Author keywords

cardiac disorders; cyanide poisoning; ECG; fire smoke; hydroxocobalamin

Indexed keywords

CYANOKIT; HYDROGEN CYANIDE; HYDROXOCOBALAMIN; UNCLASSIFIED DRUG;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; ARTICLE; ASYSTOLE; CHILD; CYANIDE POISONING; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG MEGADOSE; EARLY INTERVENTION; FEMALE; FIRE; FRANCE; HEART ARREST; HEART DISEASE; HEART INJURY; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SMOKE; SUPRAVENTRICULAR TACHYCARDIA; SYSTEMATIC REVIEW; TOXIC INHALATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIDOTES; ARRHYTHMIAS, CARDIAC; CHILD, PRESCHOOL; CYANIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMERGENCY MEDICAL SERVICES; FEMALE; HEART ARREST; HUMANS; HYDROXOCOBALAMIN; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SMOKE INHALATION INJURY; SURVIVAL ANALYSIS; YOUNG ADULT;

EID: 77951666782     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2009.09.028     Document Type: Article

References (17)

1. Alarie Y. Toxicity of fire smoke. Crit Rev Toxicol 32 (2002) 259-289
2. Dehon B., and Lhermitte M. Cyanides and anions. In: Kintz P. (Ed). Toxicologie and Pharmacologie Médico-Légales (1998), Elsevier, Paris 147-155
3. O'Flaherty E.J., and Thomas W.C. The cardiotoxicity of hydrogen cyanide as a component of polymer pyrolysis smokes. Toxicol Appl Pharmacol 63 (1982) 373-381
4. Malis C.D., and Bonventre J.V. Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. A model for post-ischemic and toxic mitochondrial damage. J Biol Chem 261 (1986) 4201-4208
5. Franchini K.G., and Krieger E.M. Cardiovascular responses of conscious rats to carotid body chemoreceptor stimulation by intravenous KCN. J Auton Nerv Syst 42 (1993) 63-69
6. Allen D.G., Eisner D.A., Pirolo J.S., and Smith G.L. The relationship between intracellular calcium and contraction-overloaded ferret papillary muscles. J Physiol 364 (1985) 169-182
7. US Department of Health and Human Services. Toxicological profile for cyanide (July 2006). http://www.atsdr.cdc.gov/toxprofiles/tp8.html#bookmark09 Accessed December 2008
8. Tuovinen H., and Blomquist P. Modelling of hydrogen cyanide formation in room fires (2003), Swedish National Testing and Research Institute, Borås, Sweden
9. Hertzberg T., Blomquist P., Dalene M., and Skarping G. Particles and isocyanate from fire (2003), Swedish National Testing and Research Institute, Borås, Sweden
10. Ballantyne B. Toxicology of cyanides. In: Ballantyne B., and Marrs T.C. (Eds). Clinical and experimental toxicology of cyanides (1987), Wright Publishers, Bristol, UK 41-46
11. Megarbane B., Delahaye A., Goldgran-Toledano D., and Baud F.J. Antidotal treatment of cyanide poisoning. J Chin Med Assoc 66 (2003) 193-203
12. Fortin JL, Ruttimann M, Domanski L, et al. Use of hydroxocobalamin. Fire Rescue International Med Congress, Las Vegas, April 15-18, 2004.
13. Fortin J.L., Giocanti J.P., Ruttimann M., and Kowalski J.J. Prehospital administration of hydroxocobalamin for smoke inhalation associated cyanide poisoning: 8 years of experience in the Paris Fire Brigade. Clin Toxicol (Phila) 44 Suppl 1 (2006) 37-44
14. Fortin J.L., Ruttimann M., Domanski L., and Kowalski J.J. Hydroxocobalamin treatment for smoke inhalation associated cyanide poisoning. Meeting the needs of fire victims. JEMS 29 Suppl (2004) 18-21
15. Baud F., Barriot P., Toffis V., et al. Elevated blood cyanide concentrations in victims of smoke inhalation. N Engl J Med 325 (1991) 1761-1766
16. Renard C., Fortin J.L., and Baud F. Terrorisme chimique et cyanides. In: de Revel M.C., Gourmelon M.C.S., Vidal P.C., and Renaudeau P.C.S. (Eds). Menace terroriste: Approche Médicale [French] (2005), John Libbey Eurotext, Montrouge, France 353-359
17. Grangeon M. Les intoxications aux cyanures, prise en charge et traitement [French]. Besançon, France: Université de Franche-Comté, Faculté de médecine et de pharmacie de Besançon. Thèse, Année 2008 - n°08-22.