Antidotal treatment of cyanide poisoning

Journal of the Chinese Medical Association

Volumn 66, Issue 4, 2003, Pages 193-203

  Mégarbane, Bruno ^a   Delahaye, Arnaud ^a   Goldgran Tolédano, Dany ^a   Baud, Frédéric J ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Antidotes; Cyanide; Hydroxocobalamin; Poisoning; Sodium thiosulfate

Indexed keywords

4 AMINOPROPIOPHENONE; 4 DIMETHYLAMINOPHENOL; ADRENALIN; AMINOPHENOL DERIVATIVE; AMYL NITRITE; ANTICONVULSIVE AGENT; ANTIDOTE; ANTIOXIDANT; BICARBONATE; CATECHOLAMINE; COBALAMIN DERIVATIVE; COBALT EDETATE; CYANIDE; CYANOKIT; HEMOGLOBIN; HYDROXOCOBALAMIN; LACTIC ACID; METHEMOGLOBIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITRITE; NITROPRUSSIDE SODIUM; NITROUS OXIDE; OXYGEN; SODIUM NITRITE; SODIUM THIOSULFATE; THIOSULFATE SULFURTRANSFERASE;

ALLERGIC REACTION; ANAPHYLACTIC SHOCK; ARTIFICIAL VENTILATION; CLINICAL FEATURE; COMA; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CYANIDE POISONING; DETOXIFICATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; FACE EDEMA; HEART VENTRICLE ARRHYTHMIA; HEMOLYSIS; HUMAN; HYPOTENSION; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LARYNX EDEMA; NEPHROTOXICITY; RESPIRATORY ARREST; RESUSCITATION; RETICULOCYTOSIS; REVIEW; SEIZURE; SENSITIVITY AND SPECIFICITY; SHOCK; SKIN DISCOLORATION; TACHYPNEA; THORAX PAIN; URINE COLOR; URTICARIA; VOMITING; BLOOD; METABOLISM;

ANTIDOTES; CYANIDES; HUMANS; HYDROXOCOBALAMIN; LACTIC ACID;

EID: 0141855036     PISSN: 17264901     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (50)

1. Aaron CK. Cyanide antidotes. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA, Hoffman RS, eds. Goldfrank's Toxicological Emergencies. Stamford: Appleton & Lange, 1998:1583-5.
2. Ballantyne B. Toxicology of Cyanides. In: Ballantyne B, Marrs TC, eds. Clinical and Experimental Toxicology of Cyanides. Bristol: Wright, 1987:41-126.
3. Davey G, Clark J. Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria. J Neurochem 1996;66:1617-24.
4. MacMillan VH. Cerebral energy metabolism in cyanide encephalopathy. J Cereb Blood Flow Metab 1989;9:156-62.
5. Lundquist P, Sörbo B. Rapid determination of toxic cyanide concentrations in blood. Clin Chem 1989;35:617-19.
6. Laforge M, Buneaux F, Houeto P, Bourgeois F, Bourdon R, Levillain P. A rapid spectrophotometric blood cyanide determination applicable to emergency toxicology. J Anal Toxicol 1994;18:173-5.
7. Vesey CJ, McAllister H, Langford RM. A simple, rapid and sensitive semimicro method for the measurement of cyanide in blood. Ann Clin Biochem 1999;36:755-8.
8. Graham DL, Laman D, Theodore J, Robin ED. Acute cyanide poisoning complicated by lactic acidosis and pulmonary edema. Arch Intern Med 1977;137:1051-5.
9. Benaissa ML, Hantson P, Bismuth C, Baud FJ. Mercury oxycyanide and mercuric cyanide poisoning: two cases. Intensive Care Med 1995;21:1051-3.
10. Bismuth C, Baud F, Djeghout H, Astier A, Aubriot D. Cyanide poisoning from propionitrile exposure. J Emerg Med 1987; 5:191-5.
11. Caravati E, Bennett D, McElwee N. Pediatric cyanide intoxication and death from an acetonitrile-containing cosmetic. J Am Med Assoc 1988;260:3470-3.
12. Vesey J. Nitroprusside cyanogenesis. In: Ballantyne B, Marrs T, eds. Clinical and Experimental Toxicology of Cyanides. Bristol: Wright, 1987:184-208.
13. Kerns WP II, Kirk MA. Cyanide and hydrogen sulfide. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland MA, Hoffman RS, eds. Goldfrank's Toxicological Emergencies. Stamford: Appleton & Lange, 1998:1570-82.
14. Ellenhorn MJ, Schonwald S, Ordog G, Wasserberger J. Hydrogen sulfide. In: Ellenhorn MJ, Schonwald S, Ordog G, Wasserberger J, eds. Medical Toxicology: Diagnosis and Treatment of Human Poisoning. Baltimore: Williams & Wilkins, 1997:1489-92.
15. Baud FJ, Barriot P, Toffis V, Riou B, Vicaut E, Lecarpentier Y, et al. Elevated blood cyanide concentrations in victims of smoke inhalation. N Engl J Med 1991;325:1761-6.
16. Baud FJ, Richter F, Julien H, Bismuth C. Pre-hospital strategy for therapeutic intervention of fire victims. Toxicol Lett 1992;64-65:273-81.
17. Borron SW, Baud FJ. Acute cyanide poisoning: clinical spectrum, diagnosis and treatment. Arch Hig Rada Toksikol 1996;47:307-22.
18. Bismuth C, Cantineau JP, Pontal P, Baud F, Garnier R, Poulos L. Cyanide poisoning. Priority to symptomatic treatment. 25 cases. Presse Med 1984;13:2493-7.
19. Bismuth C, Cantineau JP, Pontal P, Baud F, Garnier R, Poulos L, Bolo A. Priorité de l'oxygénation dans l'intoxication cyanhydrique. J Toxicol Méd 1984;4:107-21.
20. Ballantyne B, Marrs TC. Post-mortem features and criteria for the diagnosis of acute lethal cyanide poisoning. In: Ballantyne B, Marrs TC, eds. Clinical and Experimental Toxicology of Cyanides. Bristol: John Wright, 1987:217-47.
21. Baud FJ, Borron SW, Bavoux E, Astier A, Hoffman JR. Relation between plasma lactate and blood cyanide concentrations in acute cyanide poisoning. Br Med J 1996;312:26-7.
22. Baud FJ, Borron SW, Mégarbane B, Trout H, Lapostolle F, Vicaut E, et al. Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning. Crit Care Med 2002; 30:2044-51.
23. Rieders F. Cyanide. In: Sunshine J, ed. Methodology for Analytical Toxicology. Cleveland: CRC Press, 1975:113-8.
24. Olsen NS, Klein JR. Effects of cyanide on the concentration of lactate and phosphates in brain. J Biol Chem 1947;167: 739-46.
25. Katsumata Y, Sato K, Oya M, Yada S. Kinetic analysis of the shift of aerobic to anaerobic metabolism in rats during acute cyanide poisoning. Life Sci 1980;27:1509-12.
26. Salkowski AA, Penney DG. Metabolic, cardiovascular, and neurologic aspects of acute cyanide poisoning in the rat. Toxicol Lett 1995;75:19-27.
27. Dodds RG, Penney DG, Sutariya BB. Cardiovascular, metabolic and neurologic effects of carbon monoxide and cyanide in the rat. Toxicol Lett 1992;61:243-54.
28. Riou B, Baud FJ, Astier A, Barriot P, Lecarpentier Y. In vitro demonstration of antidotal efficacy of hydroxocobalamin in cyanide poisoning. J Neurosurg Anesthesiol 1990;2:296-304.
29. Cassel GE. Estimation of the convulsive effect of cyanide in rats. Pharmacol Toxicol 1995;77:259-63.
30. Brierley JB, Brown AB, Calverley J. Cyanide intoxication in the rat: physiological and neuropathological aspects. J Neurol Neurosurg Pyschiatry 1976;39:129-40.
31. Leung P, Sylvester D, Chiou F, Way LL, Way EL, Way JL. Stereospecific effect of naloxone hydrochloride on cyanide intoxication. Toxicol Appl Pharmacol 1986;83:525-30.
32. Kanthasamy AG, Borowitz JL, Isom GE. Cyanide-induced increases in plasma catecholamines: relationship to acute toxicity. Neurotoxicology 1991;12:777-84.
33. Baud FJ. Pharmacokinetic-pharmacodynamic relationships. How are they useful in human toxicology? Toxicol Lett 1998;102-103:643-8.
34. Marrs TC, Bright JE, Swanston DW. The effect of prior treatment with 4-dimethylaminophenol (DMAP) on animals experimentally poisoned with hydrogen cyanide. Arch Toxicol 1982;51:247-53.
35. Marrs TC, Swanston DW, Bright JE. 4-dimethylaminophenol and dicobalt edetate (Kelocyanor) in the treatment of experimental cyanide poisoning. Hum Toxicol 1985;4:591-600.
36. Houeto P, Hoffman JR, Imbert M, Levillain P, Baud FJ. Relation of blood cyanide to plasma cyanocobalamin concentration after a fixed dose of hydroxocobalamin in cyanide poisoning. Lancet 1995;346:605-8.
37. Thompson SJ, Bayer MJ, Schriver JA. Access to cyanide antidote kits. Ann Emerg Med 1983;12:515-6.
38. Borron SW, Baud FJ, Méric P, Seylaz J, Astier A. False elevation of blood cyanide values after sodium nitrite administration. J Toxicol Clin Toxicol 1996;34:629.
39. Moore SJ, Norris JC, Walsh DA, Hume AS. Antidotal use of methemoglobin-forming cyanide antagonists in concurrent carbon monoxide/cyanide intoxication. J Pharmacol Exp Ther 1987;242:70-3.
40. Dodds C, McKnight C. Cyanide toxicity after immersion and hazards of dicobalt edetate. BMJ 1985;291:785-6.
41. Hillman B, Bardhan KD, Bain JTB. The use of dicobalt edetate (Kelocyanor) in cyanide poisoning. Postgrad Med J 1974;50:171-4.
42. Hall AH, Rumack BH. Hydroxocobalamin/sodium thiosulfate as a cyanide antidote. J Emerg Med 1987;5:115-21.
43. Breen PH, Isserles SA, Westley J, Roizen MF, Taitelman UZ. Effect of oxygen and sodium thiosulfate during combined carbon monoxide and cyanide poisoning. Toxicol Appl Pharmacol 1995;134:229-34.
44. Astier A, Baud FJ. Complexation of intracellular cyanide by hydroxocobalamin using a human cellular model. Hum Exp Toxicol 1996;15:19-25.
45. Houeto P, Borron SW, Sandouk P, Imbert M, Levillain P, Baud FJ. Pharmacokinetics of hydroxocobalamin in smoke inhalation victims. J Toxicol Clin Toxicol 1996;34:397-404.
46. Borron SW, Vicaut E, Ruttimann M, Baud FJ. Biological tolerance of hydroxocobalamin in fire victims intoxicated by cyanide. Intensive Care Med 1997;23:S181.
47. Evans CL. Cobalt compounds as antidotes for hydrocyanic acid. Br J Pharmacol 1964;23:455-75.
48. Curry SC, Arnold-Capell P. Nitroprusside, nitroglycerine and angiotensin-converting enzyme inhibitors. Crit Care Med 1991;7:555-580.
49. Hume AS, Mozingo JR, McIntyre B, Ho IK. Antidotal efficacy of alpha-ketoglutaric acid and sodium thiosulfate in cyanide poisoning. J Toxicol Clin Toxicol 1995;33:721-4.
50. Niknahad H, O'Brien PJ. Antidotal effect of dihydroacetone against cyanide toxicity in vivo. Toxicol Appl Pharmacol 1996;138:186-91.