Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: Arginine and phenylalanine side chain groups are keys for receptor activity

Amino Acids

Volumn 38, Issue 4, 2010, Pages 985-990

  Androutsou, Maria Eleni ^a   Saifeddine, Mahmoud ^b   Hollenberg, Morley D ^b   Matsoukas, John ^a,b   Agelis, George ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Mimetics; PAR1 receptor; Pharmacophore; SFLLR; Thrombin

Indexed keywords

ARGININE; LIGAND; PHENYLALANINE; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN RECEPTOR ANTAGONIST;

ANALYTIC METHOD; ARTICLE; CALCIUM SIGNALING; CELL ASSAY; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESEARCH; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN CONFORMATION; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMIDES; ARGININE; CALCIUM SIGNALING; CELL LINE; CYCLOHEXANES; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; GUANIDINES; HUMANS; INDOLES; LIGANDS; MOLECULAR MIMICRY; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PHENYLALANINE; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 77951665570     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-009-0306-z     Document Type: Article

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