Microarray analysis of the liver in metallothionein-III null mice treated with cadmium

Journal of Toxicological Sciences

Volumn 35, Issue 2, 2010, Pages 271-273

  Honda, Akiko ^a,b   Komuro, Hiroaki ^a   Nagase, Hisamitsu ^b   Hozumi, Isao ^c   Inuzuka, Takashi ^c   Hara, Hideaki ^b   Fujiwara, Yasuyuki ^a   Satoh, Masahiko ^a  

^a AICHI GAKUIN UNIVERSITY   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^c GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cd; DNA microarray; Liver; MT III

Indexed keywords

CADMIUM; METALLOTHIONEIN III; SERUM AMYLOID A; SERUM AMYLOID A1; SERUM AMYLOID A2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION; LIVER TOXICITY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; RNA EXTRACTION; UPREGULATION; WILD TYPE;

MUS;

EID: 77951665094     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.271     Document Type: Article

References (9)

1. Erickson, J.C., Hollopeter, G., Thomas, S.A., Froelick, G.J. and Palmiter, R.D. (1997): Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures. J. Neurosci., 17, 1271-1281. (Pubitemid 27073729)
2. Honda, A., Komuro, H., Hasegawa, T., Seko, Y., Shimada, A., Nagase, H., Hozumi, I., Inuzuka, T., Hara, H., Fujiwara, Y. and Satoh, M. (2010): Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity. J. Toxicol. Sci., 35, 209-215.
3. Kayama, F., Yoshida, T., Elwell, M.R. and Luster, M.I. (1995): Role of tumor necrosis factor-alpha in cadmium-induced hepatotoxicity. Toxicol. Appl. Pharmacol., 131, 224-234.
4. Klaassen, C.D., Liu, J. and Choudhuri, S. (1999): Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol., 39, 267-294.
5. Masters, B.A., Kelly, E.J., Quaife, C.J., Brinster, R.L. and Palmiter, R.D. (1994): Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. PNAS USA, 91, 584-588.
6. Michalska, A.E. and Choo, K.H. (1993): Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. PNAS USA, 90, 8088-8092.
7. Satoh, M. (2007): Analysis of toxicity using metallothionein knock-out mice. Yakugaku Zasshi, 127, 709-717.
8. Uhlar, C.M. and Whitehead, A.S. (1999): Serum amyloid A, the major vertebrate acute-phase reactant. Eur. J. Biochem., 265, 501-523.
9. Yiangou, M. and Papaconstantinou, J. (1993): The differential induction of alpha 1-acid glycoprotein and serum amyloid A genes by heavy metals. Biochim. Biophys. Acta., 1174, 123-132.