Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity

Journal of Toxicological Sciences

Volumn 35, Issue 2, 2010, Pages 209-215

  Honda, Akiko ^a,d   Komuro, Hiroaki ^a   Hasegawa, Tatsuya ^b   Seko, Yoshiyuki ^b   Shimada, Akinori ^c   Nagase, Hisamitsu ^d   Hozumi, Isao ^e   Inuzuka, Takashi ^e   Hara, Hideaki ^d   Fujiwara, Yasuyuki ^a   Satoh, Masahiko ^a  

^a AICHI GAKUIN UNIVERSITY   (Japan)

^b YAMANASHI INSTITUTE OF ENVIRONMENTAL SCIENCES   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^e GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cd; Hepatotoxicity; Knockout mice; MT I II; MT III

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CADMIUM; METALLOTHIONEIN III;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; NULL ALLELE; WILD TYPE;

MUS;

EID: 77951661535     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.209     Document Type: Article

References (30)

1. Carrasco, J., Penkowa, M., Giralt, M., Camats, J., Molinero, A., Campbell, I.L., Palmiter, R.D. and Hidalgo, J. (2003): Role of metallothionein-III following central nervous system damage. Neurobiol. Dis., 13, 22-36.
2. Ceballos, D., Lago, N., Verdú, E., Penkowa, M., Carrasco, J., Navarro, X., Palmiter, R.D. and Hidalgo, J. (2003): Role of metallothioneins in peripheral nerve function and regeneration. Cell Mol. Life Sci., 60, 1209-1216.
3. Erickson, J.C., Hollopeter, G., Thomas, S.A., Froelick, G.J. and Palmiter, R.D. (1997): Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures. J. Neurosci., 17, 1271-1281. (Pubitemid 27073729)
4. Garrett, S.H., Phillips, V., Somji, S., Sens, M.A., Dutta, R., Park, S., Kim, D. and Sens, D.A. (2002): Transient induction of metallothionein isoform 3 (MT-3), c-fos, c-jun and c-myc in human proximal tubule cells exposed to cadmium. Toxicol. Lett., 126, 69-80.
5. Habeebu, S.S., Liu, J., Liu, Y. and Klaassen, C.D. (2000a): Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium. Toxicol. Sci., 55, 223-232.
6. 2-induced bone injury. Toxicol. Sci., 56, 211-219.
7. Hozumi, I., Suzuki, J.S., Kanazawa, H., Hara, A., Saio, M., Inuzuka, T., Miyairi, S., Naganuma, A. and Tohyama, C. (2008): Metallothionein-3 is expressed in the brain and various peripheral organs of the rat. Neurosci. Lett., 438, 54-58.
8. Klaassen, C.D., Liu, J. and Choudhuri, S. (1999): Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol., 39, 267-294.
9. Klaassen, C.D., Liu, J. and Diwan, B.A. (2009): Metallothionein protection of cadmium toxicity. Toxicol. Appl. Pharmacol., 238, 215-220.
10. Kondo, Y., Yanagiya, T., Himeno, S., Yamabe, Y., Schwartz, D., Akimoto, M., Lazo, J.S. and Imura, N. (1999): Simian virus 40-transformed metallothionein null cells showed increased sensitivity to cadmium but not to zinc, copper, mercury or nickel. Life Sci., 64, 145-150. (Pubitemid 29130578)
11. Koumura, A., Hamanaka, J., Shimazawa, M., Honda, A., Tsuruma, K., Uchida, Y., Hozumi, I., Satoh, M., Inuzuka, T. and Hara, H. (2009): Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia. Brain Res., 1292, 148-154.
12. Lazo, J.S., Kondo, Y., Dellapiazza, D., Michalska, A.E., Choo, K.H. and Pitt, B.R. (1995): Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem., 270, 5506-5510.
13. Liu, J., Liu, Y., Habeebu, S.S. and Klaassen, C.D. (1998): Susceptibility of MT-null mice to chronic CdCl2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex. Toxicol. Sci., 46, 197-203.
14. 2 exposure. Toxicol. Appl. Pharmacol., 159, 98-108.
15. Liu, J., Liu, Y., Michalska, A.E., Choo, K.H. and Klaassen, C.D. (1996): Metallothionein plays less of a protective role in cadmium-metallothionein- induced nephrotoxicity than in cadmium chloride-induced hepatotoxicity. J. Pharmacol. Exp. Ther., 276, 1216-1223.
16. Liu, Y., Liu, J., Habeebu, S.M., Waalkes, M.P. and Klaassen, C.D. (2000): Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity. Toxicol. Sci., 57, 167-176.
17. Masters, B.A., Kelly, E.J., Quaife, C.J., Brinster, R.L. and Palmiter, R.D. (1994): Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. PNAS USA, 91, 584-588.
18. Moffatt, P. and Séguin, C. (1998): Expression of the gene encoding metallothionein-3 in organs of the reproductive system. DNA Cell Biol., 17, 501-510.
19. Montoliu, C., Monfort, P., Carrasco, J., Palacios, O., Capdevila, M., Hidalgo, J. and Felipo, V. (2000): Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons. J. Neurochem., 75, 266-273. (Pubitemid 30418192)
20. Nordberg, G.F. (2009): Historical perspectives on cadmium toxicology. Toxicol. Appl. Pharmacol., 238, 192-200.
21. Nordberg, G.F., Nogawa, K., Nordberg, M. and Friberg, L.T. (2007): Cadmium. Handbook on the Toxicology of Metals Third edition (Nordberg, G.F., Fowler, B.A., Nordberg, M., Friberg, L.T., eds.), pp.445-486. Academic Press/Elsevier, Amsterdam and Boston.
22. Palmiter, R.D., Findley, S.D., Whitmore, T.E. and Durnam, D.M. (1992): MT-III, a brain-specific member of the metallothionein gene family. PNAS USA, 89, 6333-6337.
23. Park, J.D., Liu, Y. and Klaassen, C.D. (2001): Protective effect of metallothionein against the toxicity of cadmium and other metals. Toxicology, 163, 93-100.
24. Quaife, C.J., Findley, S.D., Erickson, J.C., Froelick, G.J., Kelly, E.J., Zambrowicz, B.P. and Palmiter, R.D. (1994): Induction of new metallothionein isoform (MT-IV) occurs during differentiation of stratified sqamous epithelia. Biochemistry 33, 7250-7259.
25. Rikans, L.E. and Yamano, T. (2000): Mechanisms of cadmium-mediated acute hepatotoxicity. J. Biochem. Mol. Toxicol., 14, 110-117.
26. +2-exposed human proximal tubule cells. Toxicol. Sci., 80, 358-366.
27. Uchida, Y., Gomi, F., Masumizu, T. and Miura, Y. (2002): Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging. J. Biol. Chem., 277, 32353-32359.
28. Uchida, Y., Takio, K., Titani, K., Ihara, Y. and Tomonaga, M. (1991): The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron., 7, 337-347.
29. You, H.J., Lee, K.J. and Jeong, H.G. (2002): Overexpression of human metallothionein-III prevents hydrogen peroxide-induced oxidative stress in human fibroblast. FEBS Lett., 521, 175-179.
30. Zheng, H., Liu, J., Liu, Y. and Klaassen, C.D. (1996): Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity. Toxicol. Lett., 87, 139-145.