Malondialdehyde-modified low density lipoprotein (MDA-LDL)-induced cell growth was suppressed by polycyclic aromatic hydrocarbons (PAHs)

Journal of Toxicological Sciences

Volumn 35, Issue 2, 2010, Pages 137-147

  Suzuki, Hiroyuki ^a   Sasaki, Takamitsu ^a   Kumagai, Takeshi ^a   Sakaguchi, Shuhei ^a   Nagata, Kiyoshi ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

AhR; hCYP1A1; MDA LDL; P21; PAHs

Indexed keywords

3 METHYLCHOLANTHRENE; ALPHA NAPHTHOFLAVONE; BENZO[A]PYRENE; CARBON 14; CYTOCHROME P450 1A1; HYPOXIA INDUCIBLE FACTOR 1BETA; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; POLYCYCLIC AROMATIC HYDROCARBON; PROTEIN P21; PROTEIN P53;

ARTERIOSCLEROSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION; HUMAN; HUMAN CELL; PARTHENOGENESIS; PATHOGENESIS; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

EID: 77951658695     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.137     Document Type: Article

References (38)

1. Antoniades, C., Tousoulis, D. and Stefanadis, C. (2008): Smoking in Asians: it doesn't stop at vascular endothelium. Int. J. Cardiol., 128, 151-153.
2. Aoyama, K., Yoshinari, K., Kim, H.J., Nagata, K. and Yamazoe, Y. (2009): Simultaneous expression of plural forms of human cytochrome P450 at desired ratios in HepG2 cells: adenovirus-mediated tool for cytochrome P450 reconstitution. Drug Metab. Pharmacokinet., 24, 209-217.
3. Avigan, J. (1959): The interaction between carcinogenic hydrocarbons and serumlipoproteins. Cancer Res., 19, 831-834.
4. Burke, M.D. and Mayer, R.T. (1974): Ethoxyresorufin: direct fluorometric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab. Dispos., 2, 583-588.
5. Chouraki, V., Wagner, A., Ferrieres, J., Kee, F., Bingham, A., Haas, B., Ruidavets, J.B., Evans, A., Ducimetiere, P., Amouyel, P. and Dallongeville, J. (2008): Smoking habits, waist circumference and coronary artery disease risk relationship: the PRIME study. Eur. J. Cardiovasc. Prev. Rehabil., 15, 625-630.
6. Curfs, D.M., Knaapen, A.M., Pachen, D.M., Gijbels, M.J., Lutgens, E., Smook, M.L., Kockx, M.M., Daemen, M.J. and van Schooten, F.J. (2005): Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties. FASEB. J., 19, 1290-1292.
7. Endo, K., Uno, S., Seki, T., Ariga, T., Ksumi, Y., Mitsumata, M., Yamada, S. and Makishima, M. (2008): Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene. Toxicol. Appl. Pharmacol., 230, 135-143.
8. Fogelman, A.M., Shechter, I., Seager, J., Hokom, M., Child, J.S. and Edwards, P.A. (1980): Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. PNAS USA, 77, 2214-2218. (Pubitemid 10089629)
9. Galván, N., Teske, D.E., Zhou, G., Moorthy, B., MacWilliams, P.S., Czuprynski, C.J. and Jefcoate, C.R. (2005): Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity. Toxicol. Appl. Pharmacol., 202, 244-257.
10. Goldstein, J.L. and Brown, M.S. (1977): The low-density lipoprotein pathway and its relation to atherosclerosis. Annu. Rev. Biochem., 46, 897-930.
11. Hamilton, J.A., Myers, D., Jessup, W., Cochrane, F., Byrne, R., Whitty, G. and Moss, S. (1999): Oxidized LDL can induce macrophage survival, DNA synthesis, and enhanced proliferative response to CSF-1 and GM-CSF. Arterioscler. Thromb. Vasc. Biol., 19, 98-105.
12. Harrigan, J.A., McGarrigle, B.P., Sutter, T.R. and Olson, J.R. (2006): Tissue specific induction of cytochrome P450 (CYP) 1A1 and 1B1 in rat liver and lung following in vitro (tissue slice) and in vivo exposure to benzo(a)pyrene. Toxicol. In Vitro, 20, 426-438.
13. Harrigan, J.A., Vezina, C.M., McGarrigle, B.P., Ersing, N., Box, H.C., Maccubbin, A.E. and Olson, J.R. (2004): DNA adduct formation in precision-cut rat liver and lung slices exposed to benzo[a]pyrene. Toxicol. Sci., 77, 307-314.
14. Heery, J.M., Kozak, M., Stafforini, D.M., Jones, D.A., Zimmerman, G.A., McIntyre, T.M. and Prescott, S.M. (1995): Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells. J. Clin. Invest., 96, 2322-2330.
15. Iribarren, C., Tekawa, I.S., Sidney, S. and Friedman, G.D. (1999): Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary disease, and cancer in men. N. Engl. J. Med., 340, 1773-1780.
16. Iseki, M., Ikuta, T., Kobayashi, T. and Kawajiri, K. (2005): Growth suppression of Leydig TM3 cells mediated by aryl hydrocarbon receptor. Biochem. Biophys. Res. Commun., 331, 902-908.
17. Iwano, S., Asanuma, F., Nukaya, M., Saito, T. and Kamataki, T. (2005): CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons. Biochem. Biophys. Res. Commun., 337, 708-712.
18. Iwano, S., Shibahara, N., Saito, T. and Kamataki, T. (2006): Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons. FEBS Lett., 580, 890-893. (Pubitemid 43152310)
19. Jonsson, E.M., Abrahamson, A., Brunstrom, B. and Brandt, I. (2006): Cytochrome P4501A induction in rainbow trout gills and liver following exposure to waterborne indigo, benzo[a]pyrene and 3,3′,4,4′,5- pentachlorobiphenyl. Aquat. Toxicol., 79, 226-232.
20. Kamiyama, Y., Matsubara, T., Yoshinari, K., Nagata, K., Kamimura, H. and Yamazoe, Y. (2007): Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA. Drug Metab. Pharmacokinet., 22, 287-298.
21. Kim, J.H., Stansbury, K.H., Walker, N.J., Trush, M.A., Strickland, P.T. and Sutter, T.R. (1998): Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8- diol by human cytochrome P450 1B1. Carcinogenesis, 19, 1847-1853. (Pubitemid 28474651)
22. LaCroix, A.Z., Lang, J., Scherr, P., Wallace, R.B., Cornoni-Huntley, J., Berkman, L., Curb, J.D., Evans, D. and Hennekens, C.H. (1991): Smoking and mortality among older men and women in three communities. N. Engl. J. Med., 324, 1619-1625.
23. Martens, J.S., Reiner, N.E., Herrera-Velit, P. and Steinbrecher, U.P. (1998): Phosphatidylinositol 3-kinase is involved in the induction of macrophage growth by oxidized low density lipoprotein. J. Biol. Chem., 273, 4915-4920.
24. Matsumura, T., Sakai, M., Kobori, S., Biwa, T., Takemura, T., Matsuda, H., Hakamata, H., Horiuchi, S. and Shichiri, M. (1997): Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein- induced macrophage growth. Arterioscler. Thromb. Vasc. Biol., 17, 3013-3020.
25. Miller, K.P. and Ramos, K.S. (2001): Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons. Drug Metab. Rev, 33, 1-35.
26. Ozer, N.K., Palozza, P., Boscoboinik, D. and Azzi, A. (1993): d-alpha- Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells. FEBS Lett., 322, 307-310. (Pubitemid 23144710)
27. Patton, S. and Kurtz, G.W. (1951): 2-Thiobarbituric acid as a reagent for detecting milk fat oxidation. J. Dai. Sci., 34, 669-674.
28. Plant, A.L., Benson, D.M. and Smith, L.C. (1985): Cellular uptake and intracellular localization of benzo(a)pyrene by digital fluorescence imaging microscopy. J. Cell Biol., 100, 1295-1308.
29. Remsen, J.F. and Shireman, R.B. (1981): Effect of low-density lipoprotein on the incorporation of benzo(a)pyrene by cultured cells. Cancer Res., 41, 3179-3185. (Pubitemid 11035537)
30. Ross, R. (1999): Atherosclerosis - an inflammatory disease. N. Engl. J. Med., 340, 115-126.
31. Sean, W.K. and Stephanie, P.J. (1994): Simultaneous measurement of cytochrome P4501A catalytic activity and total protein concentration with a fluorescence plate reader. Anal. Biochem., 222, 217-223.
32. Shu, H.P. and Nichols, A.V. (1979): Benzo(a)pyrene uptake by human plasma lipoproteins in vitro. Cancer Res., 39, 1224-1230. (Pubitemid 9183837)
33. Steinberg, D. and Witztum, J.L. (1990): Lipoproteins and atherogenesis. Current. concepts. JAMA, 264, 3047-3052.
34. Uno, S., Dalton, T.P., Dragin, N., Curran, C.P., Derkenne, S., Miller, M.L., Shertzer, H.G., Gonzalez, F.J. and Nebert, D.W. (2006): Oral benzo[a]pyrene in cypl knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Mol. Pharmacol., 69, 1103-1114.
35. van Grevenynghe, J., Sparfel, L., Le Vee, M., Gilot, D., Drenou, B., Fauchet, R. and Fardel, O. (2004): Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages. Biochem. Biophys. Res. Commun., 317, 708-716.
36. Willett, K.L., Ganesan, S., Patel, M., Metzger, C., Quiniou, S., Waldbieser, G. and Scheffler, B. (2006): In vivo and in vitro CYP1B mRNA expression in channel catfish. Mar. Environ. Res., 62 Suppl., S332-336.
37. Ylä-Herttuala, S., Rosenfeld, M.E., Parthasarathy, S., Sigal, E., Särkioja, T., Witztum, J.L. and Steinberg, D. (1991): Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts. J. Clin. Invest., 87, 1146-1152.
38. Zhao, G.F., Seng, J.J., Zhang, H. and She, M.P. (2005): Effects of oxidized low density lipoprotein on the growth of human artery smooth muscle cells. Chin. Med. J. (Engl.), 118, 1973-1978.