Cysteine-String Proteins (CSPs)

Encyclopedia of Neuroscience

Volumn , Issue , 2009, Pages 285-292

  Schmitz, F ^a   Fernandez Chacon R ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Blindness; Calyx of Held; Chaperone; Cysteine string protein (CSP); ERG; Exocytosis; Hsc70; Hsp40; Hsp70; Neurodegeneration; Neurodegenerative diseases; Neuromuscular junction; Ribbon synapse; SGT; SNARE complex; Synapse; Synuclein; TPR

Indexed keywords

EID: 77951636823     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-008045046-9.01368-1     Document Type: Chapter

References (20)

1. Borst J.G., Sakmann B. Calcium influx and transmitter release in a fast CNS synapse. Nature 1996, 383:431-434.
2. Braun J.E., Wilbanks S.M., Scheller R.H. The cysteine string secretory vesicle protein activates Hsc70 ATPase. Journal of Biological Chemistry 1996, 271:25989-25993.
3. Chamberlain L., Burgoyne R.D. Cysteine-string protein: The chaperone at the synapse. Journal of Neurochemistry 2000, 74:1781-1789.
4. Chamberlain L., Henry J., Burgoyne R.D. Cysteine-string proteins are associated with chromaffin granules. Journal of Biological Chemistry 1996, 271:19514-19517.
5. Chandra S., Gallardo G., Fernandez-Chacon R., Schlüter O.M., Südhof T.C. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 2005, 123:383-396.
6. Evans G.J., Morgan A., Burgoyne R.D. Tying everything together: The multiple roles of cysteine string protein (CSP) in regulated exocytosis. Traffic 2003, 4:653-659.
7. Fernandez-Chacon R., Wölfel M., Nishimune H., et al. The synaptic vesicle protein CSP α prevents presynaptic degeneration. Neuron 2004, 42:237-251.
8. Fink A.L. Chaperone-mediated protein folding. Physiological Reviews 1999, 79:425-449.
9. Gundersen C.B., Umbach J.A. Suppression cloning of the cDNAs for a candidate subunit of a presynaptic calcium channel. Neuron 1992, 9:527-537.
10. Hartl F.U., Hayer-Hartl M. Molecular chaperones in the cytosol: From nascent chain to folded protein. Science 2002, 295:1852-1858.
11. Leveque C., Pupier B., Marqueze B., et al. Interaction of the cysteine string proteins with the alpha1A subunit of P/Q-type calcium channel. Journal of Biological Chemistry 1998, 273:13488-13492.
12. Magga J.M., Jarvis S.E., Arnot M.I., Zamponi G.W., Braun J.E. Cysteine string protein regulates G protein modulation of N-type calcium channels. Neuron 2000, 28:195-204.
13. McDonough H., Patterson C. CHIP: A link between the chaperone and proteasome systems. Cell Stress & Chaperones 2003, 4:303-308.
14. Morales M., Ferrus A., Martienz P.M. Presynaptic calcium-channel currents in normal and csp mutant drosophila peptidergic terminals. European Journal of Neuroscience 1999, 11:1818-1825.
15. Ranjan R., Bronk P., Zinsmaier K.E. Cysteine string protein is required for calcium secretion coupling of evoked neurotransmission in Drosophila but not for vesicle recycling. Journal of Neuroscience 1998, 18:956-964.
16. Schmitz F., Tabares L., Khimich D., et al. CSP α-deficiency causes rapid and massive photoreceptor degeneration. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:2926-2931.
17. Südhof T.C. The synaptic vesicle cycle. Annual Review of Neuroscience 2004, 27:509-547.
18. Tobaben S., Thakur P., Fernandez-Chacon R., Südhof T.C., Rettig J., Stahl B. A trimeric protein complex functions as a synaptic chaperone machine. Neuron 2001, 21:987-999.
19. Zinsmaier K.E., Eberle K.K., Buchner E., Walter N., Benzer S. Paralysis and early death in cysteine-string protein mutants of drosophila. Science 1994, 263:977-980.
20. Zinsmaier K.E., Hofbauer A., Heimbeck G., Pflugfelder G.O., Buchner S., Buchner E. A cysteine-string protein is expressed in retina and brain of drosophila. Journal of Neurogenetics 1990, 7:15-29.