Evidences for insulator activity of the 5'UTR of the Drosophila melanogaster LTR-retrotransposon ZAM

Molecular Genetics and Genomics

Volumn 283, Issue 5, 2010, Pages 503-509

  Minervini, Crescenzio Francesco ^a   Ruggieri, Simona ^a   Traversa, Michele ^a   D'Aiuto, Leonardo ^b   Marsano, Rene Massimiliano ^a   Leronni, Daniela ^a   Centomani, Isabella ^a   De Giovanni, Claudio ^a   Viggiano, Luigi ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Drosophila melanogaster; Gene expression; Insulator; LTR retrotransposon

Indexed keywords

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CELL LINE; CELL STRAIN HEK293; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENHANCER REGION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INSULATOR ELEMENT; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RETROPOSON; ANIMAL; CYTOLOGY; GENETICS;

DROSOPHILA MELANOGASTER; HEXAPODA; MAMMALIA;

DROSOPHILA PROTEIN; REPRESSOR PROTEIN; SU(HW) PROTEIN, DROSOPHILA;

5' UNTRANSLATED REGIONS; ANIMALS; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; INSULATOR ELEMENTS; REPRESSOR PROTEINS; RETROELEMENTS; TERMINAL REPEAT SEQUENCES; TRANSFECTION;

EID: 77951631930     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-010-0529-4     Document Type: Article

References (27)

1. Blackwood EM, Kadonaga JT (1998) Going the distance: a current view of enhancer action. Science 281:60-63
2. Cai HN, Shen P (2001) EVects of cis arrangement of chromatin insulators on enhancer-blocking activity. Science 291:493-495
3. Conte C, Dastugue B, Vaury C (2002) Coupling of enhancer and insulator properties identiWed in two retrotransposons modulates their mutagenic impact on nearby genes. Mol Cell Biol 22:1767-1777
4. Elnitski L, Li J, Noguchi CT, Miller W, Hardison R (2001) A negative cis-element regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region. J Biol Chem 276:6289-6298
5. Gasser SM, Laemmli UK (1986) Cohabitation of scaVold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster. Cell 46:521-530
6. Gdula DA, Gerasimova TI, Corces VG (1996) Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila. Proc Natl Acad Sci USA 93:9378-9383
7. Gerasimova TI, Lei EP, Bushey AM, Corces VG (2007) Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila. Mol Cell 28:761-772
8. Geyer PK (1997) The role of insulator elements in deWning domains of gene expression. Curr Opin Genet Dev 7:242-248
9. Minervini CF, Marsano RM, Casieri P, Fanti L, Caizzi R, Pimpinelli S, Rocchi M, Viggiano L (2007) Heterochromatin protein 1 interacts with 5'UTR of transposable element ZAM in a sequence-speciWc fashion. Gene 393:1-10
10. Morcillo P, Rosen C, Dorsett D (1996) Genes regulating the remote wing margin enhancer in the Drosophila cut locus. Genetics 144:1143-1154
11. Nabirochkin S, Ossokina M, Heidmann T (1998) A nuclear matrix/ scaVold attachment region co-localizes with the gypsy retrotransposon insulator sequence. J Biol Chem 273:2473-2479
12. Namciu SJ, Fournier RE (2004) Human matrix attachment regions are necessary for the establishment but not the maintenance of transgene insulation in Drosophila melanogaster. Mol Cell Biol 24:10236-10245
13. Pai CY, Lei EP, Ghosh D, Corces VG (2004) The centrosomal protein CP190 is a component of the gypsy chromatin insulator. Mol Cell 16:737-748
14. Palla F, MelW R, Anello L, Di Bernardo M, Spinelli G (1997) Enhancer blocking activity located near the 3' end of the sea urchin early H2A histone gene. Proc Natl Acad Sci USA 94:2272-2277
15. Parkhurst SM, Corces VG (1986) Interactions among the gypsy transposable element and the yellow and the suppressor of hairy-wing loci in Drosophila melanogaster. Mol Cell Biol 6:47-53
16. Phillips JE, Corces VG (2009) CTCF: master weaver of the genome. Cell 137:1194-1211
17. Polikanov YS, Rubtsov MA, Studitsky VM (2007) Biochemical analysis of enhancer-promoter communication in chromatin. Methods 41:250-258
18. Spana C, Harrison DA, Corces VG (1988) The Drosophila melanogaster suppressor of Hairy-wing protein binds to speciWc sequences of the gypsy retrotransposon. Genes Dev 2:1414-1423
19. Szutorisz H, Dillon N, Tora L (2005) The role of enhancers as centres for general transcription factor recruitment. Trends Biochem Sci 30:593-599
20. Tjian R, Maniatis T (1994) Transcriptional activation: a complex puzzle with few easy pieces. Cell 77:5-8
21. Valenzuela L, Kamakaka RT (2006) Chromatin insulators. Annu Rev Genet 40:107-138
22. van der Vlag J, den Blaauwen JL, Sewalt RG, van Driel R, Otte AP (2000) Transcriptional repression mediated by polycomb group proteins and other chromatin-associated repressors is selectively blocked by insulators. J Biol Chem 275:697-704
23. Wallace JA, Felsenfeld G (2007) We gather together: insulators and genome organization. Curr Opin Genet Dev 17:400-407
24. Walters MC, Fiering S, Bouhassira EE, Scalzo D, Goeke S, Magis W, Garrick D, Whitelaw E, Martin DI (1999) The chicken beta-globin 5'HS4 boundary element blocks enhancer-mediated suppression of silencing. Mol Cell Biol 19:3714-3726
25. Wei W, Brennan MD (2001) The gypsy insulator can act as a promoterspeciWc transcriptional stimulator. Mol Cell Biol 21:7714-7720
26. West AG, Gaszner M, Felsenfeld G (2002) Insulators: many functions, many mechanisms. Genes Dev 16:271-288
27. Zhao H, Dean A (2005) Organizing the genome: enhancers and insulators. Biochem Cell Biol 83:516-524