The effect of an aqueous extract of teucrium polium on glutathione homeostasis in vitro: A possible mechanism of its hepatoprotectant action

Advances in Pharmacological Sciences

Volumn 2010, Issue , 2010, Pages

  Bomzon, Arieh ^a   Shtukmaster, Stella ^a   Ljubuncic, Predrag ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LACTATE DEHYDROGENASE; TEUCRIUM POLIUM EXTRACT;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL LEVEL; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CULTURE; LIVER PROTECTION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL;

EID: 77951587896     PISSN: 16876334     EISSN: 16876342     Source Type: Journal    
DOI: 10.1155/2010/938324     Document Type: Article

References (39)

1. Palevitch D., Yaniv Z., Medicinal Plants of the Holy Land 2000 Tel Aviv, Israel Modan
2. Parsaee H., Shafiee-Nick R., Anti-spasmodic and anti-nociceptive effects of Teucrium polium aqueous extract Iranian Biomedical Journal 2006 10 3 145 149 (Pubitemid 44049727)
3. Suboh S. M., Bilto Y. Y., Aburjai T. A., Protective effects of selected medicinal plants against protein degradation, lipid peroxidation and deformability loss of oxidatively stressed human erythrocytes Phytotherapy Research 2004 18 4 280 284
4. Ljubuncic P., Azaizeh H., Portnaya I., Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel Journal of Ethnopharmacology 2005 99 1 43 47 (Pubitemid 40569399)
5. Ljubuncic P., Dakwar S., Portnaya I., Cogan U., Azaizeh H., Bomzon A., Aqueous extracts of Teucrium polium possess remarkable antioxidant activity in vitro Evidence-Based Complementary and Alternative Medicine 2006 3 3 329 338 (Pubitemid 44310276)
6. Ljubuncic P., Tanne Z., Bomzon A., Evidence of a systemic phenomenon for oxidative stress in cholestatic liver disease Gut 2000 47 5 710 716
7. Ljubuncic P., Bomzon A., Ali S., Friedman S. L., Mann D. A., Liver disease, oxidative stress and ursodeoxycholic acid Liver Diseases: Biochemical Mechanisms and New Therapeutic Insights 2006 New Hampshire, NH, USA Science
8. Knowles B. B., Howe C. C., Aden D. P., Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen Science 1980 209 4455 497 499
9. Fry J. R., Hammond A. H., Assessment of the functional integrity of hepatocytes: a brief review Alternatives to Laboratory Animals 1993 21 324 329
10. Freshney R. I., Culture of Animal Cells: A Manual of Basic Technique 2000 New York, NY, USA John Wiley Sons
11. Mosmann T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 1983 65 1-2 55 63 (Pubitemid 14203433)
12. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J., Protein measurement with the Folin phenol reagent The Journal of Biological Chemistry 1951 193 1 265 275
13. Tietze F., Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues Analytical Biochemistry 1969 27 3 502 522
14. Flohe L., Gnzler W. A., Assays of glutathione peroxidase Methods in Enzymology 1984 105 114 121 (Pubitemid 14165378)
15. Carlberg I., Mannervik B., Glutathione reductase Methods in Enzymology 1985 113 484 490 (Pubitemid 16195819)
16. Lu S. C., Regulation of hepatic glutathione synthesis: current concepts and controversies FASEB Journal 1999 13 10 1169 1183
17. Meierjohann S., Walter R. D., Mller S., Glutathione synthetase from Plasmodium falciparum Biochemical Journal 2002 363 3 833 838 (Pubitemid 34526406)
18. Panovska T. K., Kulevanova S., Stefova M., In vitro antioxidant activity of some Teucrium species (Lamiaceae) Acta Pharmaceutica 2005 55 2 207 214 (Pubitemid 40992432)
19. Rizk A. M., Hammouda F. M., Rimpler H., Kamel A., Iridoids and flavonoids of Teucrium polium herb Planta Medica 1986 2 87 88 (Pubitemid 16110489)
20. Havsteen B. H., The biochemistry and medical significance of the flavonoids Pharmacology and Therapeutics 2002 96 2-3 67 202
21. Rice-Evans C., Flavonoids and isoflavones: absorption, metabolism, and bioactivity Free Radical Biology and Medicine 2004 36 7 827 828
22. Williams R. J., Spencer J. P. E., Rice-Evans C., Flavonoids: antioxidants or signalling molecules? Free Radical Biology and Medicine 2004 36 7 838 849 (Pubitemid 38352901)
23. Konyalioglu S., Karamenderes C., The protective effects of Achillea L. species native in Turkey against H2O2 -induced oxidative damage in human erythrocytes and leucocytes Journal of Ethnopharmacology 2005 102 2 221 227 (Pubitemid 41483562)
24. Zhang Y. M. C., Protective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells Toxicological Sciences 2005 88 2 545 550
25. Myhrstad M. C. W., Carlsen H., Nordstrm O., Blomhoff R., Moskaug J. O., Flavonoids increase the intracellular glutathione level by transactivation of the -glutamylcysteine synthetase catalytical subunit promoter Free Radical Biology and Medicine 2002 32 5 386 393 (Pubitemid 34178348)
26. Moskaug J. O., Carlsen H., Myhrstad M. C., Blomhoff R., Polyphenols and glutathione synthesis regulation The American Journal of Clinical Nutrition 2005 81 1 277 283
27. Zal F., Vasei M., Rasti M., Vessal M., Hepatotoxicity associated with hypoglycemic effects of Teucrium polium in diabetic rats Archives of Iranian Medicine 2001 4 188 192
28. Loeper J., Descatoire V., Letteron P., Hepatotoxicity of germander in mice Gastroenterology 1994 106 2 464 472 (Pubitemid 24041225)
29. De Berardinis V., Moulis C., Maurice M., Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes Molecular Pharmacology 2000 58 3 542 551
30. Mazokopakis E., Lazaridou S., Tzardi M., Mixaki J., Diamantis I., Ganotakis E., Acute cholestatic hepatitis caused by Teucrium polium L. Phytomedicine 2004 11 1 83 84 (Pubitemid 38196801)
31. Mattei A., Rucay P., Samuel D., Feray C., Reynes M., Bismuth H., Liver transplantation for severe acute liver failure after herbal medicine (Teucrium polium) administration Journal of Hepatology 1995 22 5 597
32. Larrey D., Hepatotoxicity of herbal remedies Journal of Hepatology 1997 26 1 47 51 (Pubitemid 127777238)
33. Polymeros D., Kamberoglou D., Tzias V., Acute cholestatic hepatitis caused by Teucrium polium (golden germander) with transient appearance of antimitochondrial antibody Journal of Clinical Gastroenterology 2002 34 1 100 101 (Pubitemid 34038492)
34. Starakis I., Siagris D., Leonidou L., Mazokopakis E., Tsamandas A., Karatza C., Hepatitis caused by the herbal remedy Teucrium polium L. European Journal of Gastroenterology and Hepatology 2006 18 6 681 683 (Pubitemid 43804653)
35. Mazokopakis E. E., Papadakis J. A., Kofteridis D. P., Unusual causes of intrahepatic cholestatic liver disease World Journal of Gastroenterology 2007 13 12 1879 1882 (Pubitemid 46710808)
36. Savvidou S., Goulis J., Giavazis I., Patsiaoura K., Hytiroglou P., Arvanitakis C., Herb-induced hepatitis by Teucrium polium L.: report of two cases and review of the literature European Journal of Gastroenterology and Hepatology 2007 19 6 507 511 (Pubitemid 46725758)
37. Chitturi S., Farrell G. C., Hepatotoxic slimming aids and other herbal hepatotoxins Journal of Gastroenterology and Hepatology 2008 23 3 366 373 (Pubitemid 351342073)
38. Al-Ashban R. M., Barrett D. A., Shah A. H., Effects of chronic treatment with ethanolic extract of Teucrium polium in mice Journal of Herbs, Spices and Medicinal Plants 2006 11 4 27 36 (Pubitemid 44161601)
39. Shahraki M. R., Arab M. R., Mirimokaddam E., Palan M. J., The effect of Teucrium polium (Calpoureh) on liver function, serum lipids and glucose in diabetic male rats Iranian Biomedical Journal 2007 11 1 65 68 (Pubitemid 46263062)