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Volumn 6, Issue 9, 2010, Pages 1933-1940

Cationic antimicrobial peptides: A physical basis for their selective membrane-disrupting activity

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPHILICITY; ANIONIC LIPIDS; ANTIMICROBIAL PEPTIDE; AREA-CHANGES; CATIONIC ANTIMICROBIAL PEPTIDES; COARSE-GRAINED; HOST CELLS; HOST DEFENSE; LIPID COMPOSITION; LIVING ORGANISMS; MEMBRANE PARAMETERS; MEMBRANE SURFACE; MICROBIAL KILLING; MODE OF ACTION; NEW THERAPEUTIC AGENT; OPTIMAL ACTIVITY; PHYSICAL MODEL; SALT CONCENTRATION; SELECTIVE MEMBRANES; SURFACE COVERAGES;

EID: 77951585447     PISSN: 1744683X     EISSN: 17446848     Source Type: Journal    
DOI: 10.1039/b922985j     Document Type: Article
Times cited : (15)

References (34)
  • 1
    • 0037165196 scopus 로고    scopus 로고
    • M. Zasloff Nature 2002 415 389 395
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 15
    • 0035853022 scopus 로고    scopus 로고
    • The main targets of some peptides are internal components, leading to intracellular killing.2,14 Interestingly, membrane-active AMPs can catalyze the entry of these cell-penetrating peptides into the cytoplasm. See, for instance intracellular killing.2,14 Interestingly, membrane-active AMPs can catalyze the entry of these cell-penetrating peptides into the cytoplasm. See, for instance, G. Kragol, S. Lovas, G. Varadi B. A. Condie, R. Hoffmann and L. Otvos, Biochemistry, 2001, 40 3016-3026.
    • The main targets of some peptides are internal components, leading to
    • (2001) Biochemistry , vol.40 , pp. 3016-3026
    • Kragol, G.1    Lovas, S.2    Varadi, G.3    Condie, B.A.4    Hoffmann, R.5    Otvos, L.6
  • 23
    • 36849051285 scopus 로고    scopus 로고
    • For a membrane consisting of (neutral) dipolar and anionic lipids, its dipolar interaction with a cationic molecule is shown to be a small perturbation. SeeA. Haugen and S. May, J. Chem. Phys., 2007, 127, 215104-1 215104-8. For a similar reason, one can ignore dipolar interactions of neutral polar residues on a cationic peptide.
    • (2007) J. Chem. Phys. , vol.127 , pp. 2151041-2151048
    • Haugen, A.1    May, S.2
  • 26
    • 0004150063 scopus 로고    scopus 로고
    • Cambridge University Press, Cambridge, Because of the way we construct the entropy term in eqn (6), i.e., the last term, the free-energy minimization here is equivalent to balancing the chemical potentials of the peptides in bulk and those bound to the surface
    • D. Boal, Mechanics of the Cell, Cambridge University Press, Cambridge, 2002
    • (2002) Mechanics of the Cell
    • Boal, D.1
  • 33
    • 77951602841 scopus 로고    scopus 로고
    • For AMPs primarily as membrane disrupters, see refs 4, 5, 7-12. Some AMPs are multifunctional and the two sets of references here are not necessarily mutually exclusive
    • For AMPs primarily as membrane disrupters, see refs 4, 5, 7-12. Some AMPs are multifunctional and the two sets of references here are not necessarily mutually exclusive
  • 34
    • 77951599018 scopus 로고    scopus 로고
    • "Good" AMPs are those that are coil-like in bulk but undergo compaction on a membrane.4,20 The particular one in Fig. 1 assumes an α-helical structure
    • "Good" AMPs are those that are coil-like in bulk but undergo compaction on a membrane.4,20 The particular one in Fig. 1 assumes an α-helical structure


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.