-
1
-
-
63149117340
-
Down syndrome - recent progress and future prospects
-
F. K. Wiseman, K. A. Alford, V. L. Tybulewicz, E. M. Fisher, Down syndrome - recent progress and future prospects. Hum. Mol. Genet. 18 (R1), R75-R83 (2009).
-
(2009)
Hum. Mol. Genet.
, vol.18
, Issue.R1
-
-
Wiseman, F.K.1
Alford, K.A.2
Tybulewicz, V.L.3
Fisher, E.M.4
-
2
-
-
77951836101
-
Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome
-
A. Salehi, M. Faizi, D. Colas, J. Valletta, J. Laguna, R. Takimoto-Kimura, A. Kleschevnikov, S. L. Wagner, P. Aisen, M. Shamloo, W. C. Mobley, Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci. Transl. Med. 1, 7ra17 (2009).
-
(2009)
Sci. Transl. Med.
, vol.1
-
-
Salehi, A.1
Faizi, M.2
Colas, D.3
Valletta, J.4
Laguna, J.5
Takimoto-Kimura, R.6
Kleschevnikov, A.7
Wagner, S.L.8
Aisen, P.9
Shamloo, M.10
Mobley, W.C.11
-
4
-
-
34548264230
-
Classification of human chromosome 21 gene-expression variations in Down syndrome: Impact on disease phenotypes
-
E. Aït Yahya-Graison, J. Aubert, L. Dauphinot, I. Rivals, M. Prieur, G. Golfier, J. Rossier, L. Personnaz, N. Creau, H. Bléhaut, S. Robin, J. M. Delabar, M. C. Potier, Classification of human chromosome 21 gene-expression variations in Down syndrome: Impact on disease phenotypes. Am. J. Hum. Genet. 81, 475-491 (2007).
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 475-491
-
-
Aït Yahya-Graison, E.1
Aubert, J.2
Dauphinot, L.3
Rivals, I.4
Prieur, M.5
Golfier, G.6
Rossier, J.7
Personnaz, L.8
Creau, N.9
Bléhaut, H.10
Robin, S.11
Delabar, J.M.12
Potier, M.C.13
-
5
-
-
34547811451
-
Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance
-
P. Prandini, S. Deutsch, R. Lyle, M. Gagnebin, C. Delucinge Vivier, M. Delorenzi, C. Gehrig, P. Descombes, S. Sherman, F. Dagna Bricarelli, C. Baldo, A. Novelli, B. Dallapiccola, S. E. Antonarakis, Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance. Am. J. Hum. Genet. 81, 252-263 (2007).
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 252-263
-
-
Prandini, P.1
Deutsch, S.2
Lyle, R.3
Gagnebin, M.4
Delucinge Vivier, C.5
Delorenzi, M.6
Gehrig, C.7
Descombes, P.8
Sherman, S.9
Dagna Bricarelli, F.10
Baldo, C.11
Novelli, A.12
Dallapiccola, B.13
Antonarakis, S.E.14
-
6
-
-
0029114706
-
A mouse model for Down syndrome exhibits learning and behaviour deficits
-
R. H. Reeves, N. G. Irving, T. H. Moran, A. Wohn, C. Kitt, S. S. Sisodia, C. Schmidt, R. T. Bronson, M. T. Davisson, A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat. Genet. 11, 177-184 (1995).
-
(1995)
Nat. Genet.
, vol.11
, pp. 177-184
-
-
Reeves, R.H.1
Irving, N.G.2
Moran, T.H.3
Wohn, A.4
Kitt, C.5
Sisodia, S.S.6
Schmidt, C.7
Bronson, R.T.8
Davisson, M.T.9
-
7
-
-
0025038831
-
Some morphometric observations on the brains of patients with Down's syndrome: Their relationship to age and dementia
-
D. M. Mann, M. C. Royston, C. R. Ravindra, Some morphometric observations on the brains of patients with Down's syndrome: Their relationship to age and dementia. J. Neurol. Sci. 99, 153-164 (1990).
-
(1990)
J. Neurol. Sci.
, vol.99
, pp. 153-164
-
-
Mann, D.M.1
Royston, M.C.2
Ravindra, C.R.3
-
8
-
-
60549092240
-
The locus coeruleus and noradrenergic modulation of cognition
-
S. J. Sara, The locus coeruleus and noradrenergic modulation of cognition. Nat. Rev. Neurosci. 10, 211-223 (2009).
-
(2009)
Nat. Rev. Neurosci.
, vol.10
, pp. 211-223
-
-
Sara, S.J.1
-
9
-
-
0027530377
-
The effects of L-threo-3,4-dihydroxyphenylserine on the total norepinephrine and dopamine concentrations in the cerebrospinal fluid and freezing gait in parkinsonian patients
-
H. Tohgi, T. Abe, S. Takahashi, The effects of L-threo-3,4- dihydroxyphenylserine on the total norepinephrine and dopamine concentrations in the cerebrospinal fluid and freezing gait in parkinsonian patients. J. Neural Transm. Park. Dis. Dement. Sect. 5, 27-34 (1993).
-
(1993)
J. Neural Transm. Park. Dis. Dement. Sect.
, vol.5
, pp. 27-34
-
-
Tohgi, H.1
Abe, T.2
Takahashi, S.3
-
10
-
-
33847770509
-
L-Dihydroxyphenylserine (L-DOPS): A norepinephrine prodrug
-
D. S. Goldstein, L-Dihydroxyphenylserine (L-DOPS): A norepinephrine prodrug. Cardiovasc. Drug Rev. 24, 189-203 (2006).
-
(2006)
Cardiovasc. Drug Rev.
, vol.24
, pp. 189-203
-
-
Goldstein, D.S.1
-
11
-
-
38549087860
-
Meta-analysis of suicide-related behavior events in patients treated with atomoxetine
-
M. E. Bangs, S. Tauscher-Wisniewski, J. Polzer, S. Zhang, N. Acharya, D. Desaiah, P. T. Trzepacz, A. J. Allen, Meta-analysis of suicide-related behavior events in patients treated with atomoxetine. J. Am. Acad. Child Adolesc. Psychiatry 47, 209-218 (2008).
-
(2008)
J. Am. Acad. Child Adolesc. Psychiatry
, vol.47
, pp. 209-218
-
-
Bangs, M.E.1
Tauscher-Wisniewski, S.2
Polzer, J.3
Zhang, S.4
Acharya, N.5
Desaiah, D.6
Trzepacz, P.T.7
Allen, A.J.8
-
12
-
-
0034125007
-
Incidence and course of dementia in people with Down's syndrome: Findings from a population-based study
-
A. J. Holland, J. Hon, F. A. Huppert, F. Stevens, Incidence and course of dementia in people with Down's syndrome: Findings from a population-based study. J. Intellect. Disabil. Res. 44, 138-146 (2000).
-
(2000)
J. Intellect. Disabil. Res.
, vol.44
, pp. 138-146
-
-
Holland, A.J.1
Hon, J.2
Huppert, F.A.3
Stevens, F.4
-
13
-
-
0034198889
-
Prevalence of dementia and impact on intellectual disability services
-
M. P. Janicki, A. J. Dalton, Prevalence of dementia and impact on intellectual disability services. Ment. Retard. 38, 276-288 (2000).
-
(2000)
Ment. Retard.
, vol.38
, pp. 276-288
-
-
Janicki, M.P.1
Dalton, A.J.2
-
14
-
-
0029820042
-
The prevalence of dementia in Down syndrome
-
P. Johannsen, J. E. Christensen, J. Mai, The prevalence of dementia in Down syndrome. Dementia 7, 221-225 (1996).
-
(1996)
Dementia
, vol.7
, pp. 221-225
-
-
Johannsen, P.1
Christensen, J.E.2
Mai, J.3
-
15
-
-
0026492005
-
Disease-specific patterns of locus coeruleus cell loss
-
D. C. German, K. F. Manaye, C. L. White 3rd, D. J. Woodward, D. D. McIntire, W. K. Smith, R. N. Kalaria, D. M. Mann, Disease-specific patterns of locus coeruleus cell loss. Ann. Neurol. 32, 667-676 (1992).
-
(1992)
Ann. Neurol.
, vol.32
, pp. 667-676
-
-
German, D.C.1
Manaye, K.F.2
White III, C.L.3
Woodward, D.J.4
McIntire, D.D.5
Smith, W.K.6
Kalaria, R.N.7
Mann, D.M.8
-
16
-
-
0037337815
-
Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
-
C. Zarow, S. A. Lyness, J. A. Mortimer, H. C. Chui, Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch. Neurol. 60, 337-341 (2003).
-
(2003)
Arch. Neurol.
, vol.60
, pp. 337-341
-
-
Zarow, C.1
Lyness, S.A.2
Mortimer, J.A.3
Chui, H.C.4
-
17
-
-
0028907136
-
Image analyser-assisted morphometry of the locus coeruleus in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis
-
W. J. Hoogendijk, C. W. Pool, D. Troost, E. van Zwieten, D. F. Swaab, Image analyser-assisted morphometry of the locus coeruleus in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Brain 118, 131-143 (1995).
-
(1995)
Brain
, vol.118
, pp. 131-143
-
-
Hoogendijk, W.J.1
Pool, C.W.2
Troost, D.3
Van Zwieten, E.4
Swaab, D.F.5
-
18
-
-
34548287931
-
Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice
-
J. N. O'Neil, P. R. Mouton, Y. Tizabi, M. A. Ottinger, D. L. Lei, D. K. Ingram, K. F. Manaye, Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. J. Chem. Neuroanat. 34, 102-107 (2007).
-
(2007)
J. Chem. Neuroanat.
, vol.34
, pp. 102-107
-
-
O'Neil, J.N.1
Mouton, P.R.2
Tizabi, Y.3
Ottinger, M.A.4
Lei, D.L.5
Ingram, D.K.6
Manaye, K.F.7
-
19
-
-
58149394415
-
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease
-
Y. Liu, M. J. Yoo, A. Savonenko, W. Stirling, D. L. Price, D. R. Borchelt, L. Mamounas, W. E. Lyons, M. E. Blue, M. K. Lee, Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. J. Neurosci. 28, 13805-13814 (2008).
-
(2008)
J. Neurosci.
, vol.28
, pp. 13805-13814
-
-
Liu, Y.1
Yoo, M.J.2
Savonenko, A.3
Stirling, W.4
Price, D.L.5
Borchelt, D.R.6
Mamounas, L.7
Lyons, W.E.8
Blue, M.E.9
Lee, M.K.10
-
20
-
-
34249281253
-
Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease
-
S. Kalinin, V. Gavrilyuk, P. E. Polak, R. Vasser, J. Zhao, M. T. Heneka, D. L. Feinstein, Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease. Neurobiol. Aging 28, 1206-1214 (2007).
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1206-1214
-
-
Kalinin, S.1
Gavrilyuk, V.2
Polak, P.E.3
Vasser, R.4
Zhao, J.5
Heneka, M.T.6
Feinstein, D.L.7
-
21
-
-
0029074855
-
Effects of Alzheimer's disease and normal aging on cerebrospinal fluid norepinephrine responses to yohimbine and clonidine
-
E. R. Peskind, D. Wingerson, S. Murray, M. Pascualy, D. J. Dobie, P. Le Corre, R. Le Verge, R. C. Veith, M. A. Raskind, Effects of Alzheimer's disease and normal aging on cerebrospinal fluid norepinephrine responses to yohimbine and clonidine. Arch. Gen. Psychiatry 52, 774-782 (1995).
-
(1995)
Arch. Gen. Psychiatry
, vol.52
, pp. 774-782
-
-
Peskind, E.R.1
Wingerson, D.2
Murray, S.3
Pascualy, M.4
Dobie, D.J.5
Le Corre, P.6
Le Verge, R.7
Veith, R.C.8
Raskind, M.A.9
-
22
-
-
32544460565
-
Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies
-
P. Szot, S. S. White, J. L. Greenup, J. B. Leverenz, E. R. Peskind, M. A. Raskind, Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies. J. Neurosci. 26, 467-478 (2006).
-
(2006)
J. Neurosci.
, vol.26
, pp. 467-478
-
-
Szot, P.1
White, S.S.2
Greenup, J.L.3
Leverenz, J.B.4
Peskind, E.R.5
Raskind, M.A.6
-
23
-
-
33745512851
-
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration
-
A. Salehi, J. D. Delcroix, P. V. Belichenko, K. Zhan, C. Wu, J. S. Valletta, R. Takimoto-Kimura, A. M. Kleschevnikov, K. Sambamurti, P. P. Chung, W. Xia, A. Villar, W. A. Campbell, L. S. Kulnane, R. A. Nixon, B. T. Lamb, C. J. Epstein, G. B. Stokin, L. S. Goldstein, W. C. Mobley, Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 51, 29-42 (2006).
-
(2006)
Neuron
, vol.51
, pp. 29-42
-
-
Salehi, A.1
Delcroix, J.D.2
Belichenko, P.V.3
Zhan, K.4
Wu, C.5
Valletta, J.S.6
Takimoto-Kimura, R.7
Kleschevnikov, A.M.8
Sambamurti, K.9
Chung, P.P.10
Xia, W.11
Villar, A.12
Campbell, W.A.13
Kulnane, L.S.14
Nixon, R.A.15
Lamb, B.T.16
Epstein, C.J.17
Stokin, G.B.18
Goldstein, L.S.19
Mobley, W.C.20
more..
-
24
-
-
33947673494
-
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
-
F. Fernandez, W. Morishita, E. Zuniga, J. Nguyen, M. Blank, R. C. Malenka, C. C. Garner, Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome. Nat. Neurosci. 10, 411-413 (2007).
-
(2007)
Nat. Neurosci.
, vol.10
, pp. 411-413
-
-
Fernandez, F.1
Morishita, W.2
Zuniga, E.3
Nguyen, J.4
Blank, M.5
Malenka, R.C.6
Garner, C.C.7
-
25
-
-
4644250821
-
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome
-
A. M. Kleschevnikov, P. V. Belichenko, A. J. Villar, C. J. Epstein, R. C. Malenka, W. C. Mobley, Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J. Neurosci. 24, 8153-8160 (2004).
-
(2004)
J. Neurosci.
, vol.24
, pp. 8153-8160
-
-
Kleschevnikov, A.M.1
Belichenko, P.V.2
Villar, A.J.3
Epstein, C.J.4
Malenka, R.C.5
Mobley, W.C.6
-
26
-
-
43649094588
-
Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test
-
A. C. Costa, J. J. Scott-McKean, M. R. Stasko, Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test. Neuropsychopharmacology 33, 1624-1632 (2007).
-
(2007)
Neuropsychopharmacology
, vol.33
, pp. 1624-1632
-
-
Costa, A.C.1
Scott-McKean, J.J.2
Stasko, M.R.3
-
27
-
-
10744222044
-
Effects of donepezil on cognitive functioning in Down syndrome
-
N. Johnson, C. Fahey, B. Chicoine, G. Chong, D. Gitelman, Effects of donepezil on cognitive functioning in Down syndrome. Am. J. Ment. Retard. 108, 367-372 (2003).
-
(2003)
Am. J. Ment. Retard.
, vol.108
, pp. 367-372
-
-
Johnson, N.1
Fahey, C.2
Chicoine, B.3
Chong, G.4
Gitelman, D.5
-
28
-
-
0036311075
-
Down syndrome and Alzheimer disease: Response to donepezil
-
I. T. Lott, K. Osann, E. Doran, L. Nelson, Down syndrome and Alzheimer disease: Response to donepezil. Arch. Neurol. 59, 1133-1136 (2002).
-
(2002)
Arch. Neurol.
, vol.59
, pp. 1133-1136
-
-
Lott, I.T.1
Osann, K.2
Doran, E.3
Nelson, L.4
-
29
-
-
3042857513
-
Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: Implications for the intellectual disability population
-
V. P. Prasher, Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: Implications for the intellectual disability population. Int. J. Geriatr. Psychiatry 19, 509-515 (2004).
-
(2004)
Int. J. Geriatr. Psychiatry
, vol.19
, pp. 509-515
-
-
Prasher, V.P.1
-
30
-
-
34447314736
-
Preliminary study of the safety and efficacy of donepezil hydrochloride in children with Down syndrome: A clinical report series
-
G. A. Spiridigliozzi, J. H. Heller, B. G. Crissman, J. A. Sullivan-Saarela, R. Eells, D. Dawson, J. Li, P. S. Kishnani, Preliminary study of the safety and efficacy of donepezil hydrochloride in children with Down syndrome: A clinical report series. Am. J. Med. Genet. A. 143A, 1408-1413 (2007).
-
(2007)
Am. J. Med. Genet. A.
, vol.143 A
, pp. 1408-1413
-
-
Spiridigliozzi, G.A.1
Heller, J.H.2
Crissman, B.G.3
Sullivan-Saarela, J.A.4
Eells, R.5
Dawson, D.6
Li, J.7
Kishnani, P.S.8
-
31
-
-
68049104151
-
The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome
-
P. S. Kishnani, B. R. Sommer, B. L. Handen, B. L. Seltzer, G. T. Capone, G. A. Spiridigliozzi, J. H. Heller, S. Richardson, T. McRae, The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome. Am. J. Med. Genet. A. 149A, 1641-1654 (2009).
-
(2009)
Am. J. Med. Genet. A.
, vol.149 A
, pp. 1641-1654
-
-
Kishnani, P.S.1
Sommer, B.R.2
Handen, B.L.3
Seltzer, B.L.4
Capone, G.T.5
Spiridigliozzi, G.A.6
Heller, J.H.7
Richardson, S.8
McRae, T.9
-
32
-
-
0037438328
-
Donepezil for the treatment of language deficits in adults with Down syndrome: A preliminary 24-week open trial
-
J. H. Heller, G. A. Spiridigliozzi, J. A. Sullivan, P. M. Doraiswamy, R. R. Krishnan, P. S. Kishnani, Donepezil for the treatment of language deficits in adults with Down syndrome: A preliminary 24-week open trial. Am. J. Med. Genet. A. 116A, 111-116 (2003).
-
(2003)
Am. J. Med. Genet. A.
, vol.116 A
, pp. 111-116
-
-
Heller, J.H.1
Spiridigliozzi, G.A.2
Sullivan, J.A.3
Doraiswamy, P.M.4
Krishnan, R.R.5
Kishnani, P.S.6
-
33
-
-
4744352150
-
Donepezil effects on language in children with Down syndrome: Results of the first 22-week pilot clinical trial
-
J. H. Heller, G. A. Spiridigliozzi, P. M. Doraiswamy, J. A. Sullivan, B. G. Crissman, P. S. Kishnani, Donepezil effects on language in children with Down syndrome: Results of the first 22-week pilot clinical trial. Am. J. Med. Genet. A. 130A, 325-326 (2004).
-
(2004)
Am. J. Med. Genet. A.
, vol.130 A
, pp. 325-326
-
-
Heller, J.H.1
Spiridigliozzi, G.A.2
Doraiswamy, P.M.3
Sullivan, J.A.4
Crissman, B.G.5
Kishnani, P.S.6
-
34
-
-
70349641700
-
Cholinesterase inhibitors and hospitalization for bradycardia: A population-based study
-
L. Y. Park-Wyllie, M. M. Mamdani, P. Li, S. S. Gill, A. Laupacis, D. N. Juurlink, C. Brayne, Cholinesterase inhibitors and hospitalization for bradycardia: A population-based study. PLoS Med. 6, e1000157 (2009).
-
(2009)
PLoS Med
, vol.6
-
-
Park-Wyllie, L.Y.1
Mamdani, M.M.2
Li, P.3
Gill, S.S.4
Laupacis, A.5
Juurlink, D.N.6
Brayne, C.7
-
35
-
-
35348992641
-
Education and children with Down syndrome: Neuroscience, development, and intervention
-
D. J. Fidler, L. Nadel, Education and children with Down syndrome: Neuroscience, development, and intervention. Ment. Retard. Dev. Disabil. Res. Rev. 13, 262-271 (2007).
-
(2007)
Ment. Retard. Dev. Disabil. Res. Rev.
, vol.13
, pp. 262-271
-
-
Fidler, D.J.1
Nadel, L.2
|