Morphology engineering of Aspergillus niger for improved enzyme production

Biotechnology and Bioengineering

Volumn 105, Issue 6, 2010, Pages 1058-1068

  Driouch, Habib ^a   Sommer, Becky ^a   Wittmann, Christoph ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Filamentous fungi; Microparticle; Mycelium; Pellet; Submerged cultivation

Indexed keywords

ALUMINUM OXIDE PARTICLES; ASPERGILLUS NIGER; CELLULAR AGGREGATES; CO-EXPRESSION; CONCENTRATION OF; CULTIVATION PROCESS; DIFFERENT SIZES; ENZYME PRODUCTION; FILAMENTOUS FUNGI; GLUCOAMYLASE; GREEN FLUORESCENT PROTEIN; INTRACELLULAR ENZYME; MICRO PARTICLES; MORPHOLOGICAL DEVELOPMENT; MORPHOLOGICAL FORMS; NIGER; PARTICLE COMPOSITION; PELLET SURFACES; PROTEIN PRODUCTION; SHAKE FLASKS; SUBMERGED CULTIVATION; SUBMERGED CULTURES; THIN LAYERS;

BOTTLES; CELL CULTURE; ENZYMES; IMAGE ANALYSIS; MORPHOLOGY; ORE PELLETS; PELLETIZING; SILICATES;

FUNGI;

ALUMINUM OXIDE; CITRIC ACID; ENZYME; FRUCTOFURANOSIDASE; GLUCAN 1,4 ALPHA GLUCOSIDASE; GREEN FLUORESCENT PROTEIN; OXALIC ACID; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS NIGER; BIOENGINEERING; CONIDIUM; ENZYME SYNTHESIS; FUNGUS HYPHAE; FUNGUS SPORE; MORPHOLOGY; MYCELIUM; NONHUMAN; SPECIES CULTIVATION;

ALUMINUM OXIDE; ASPERGILLUS NIGER; BETA-FRUCTOFURANOSIDASE; CELL CULTURE TECHNIQUES; GLUCAN 1,4-ALPHA-GLUCOSIDASE; GLUCOSE; GREEN FLUORESCENT PROTEINS; HYDROGEN-ION CONCENTRATION; HYPHAE; KINETICS; MICROSPHERES; MYCELIUM; MYCOLOGY; PARTICLE SIZE; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

ASPERGILLUS NIGER; FUNGI;

EID: 77951546919     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22614     Document Type: Article

References (26)

1. Bocking SP, Wiebe MG, Robson GD, Hansen K, Christiansen LH, Trinci AP. 1999. Effect of branch frequency in Aspergillus oryzae on protein secretion and culture viscosity. Biotechnol Bioeng 65(6):638-648.
2. De Nicolas-Santiago S, Regalado-Gonzalez C, Garcia-Almendárez B, Fernández FJ, Tellez-Jurado A, Huerta-Ochoa S. 2006. Physiological, morphological, and mannanase production studies on Aspergillus niger uam-gs1 mutants. Electron J Biotechnol 9:50-60. (Pubitemid 43200926)
3. Gibbs PA, Seviour RJ, Schmid F. 2000. Growth of filamentous fungi in submerged culture: Problems and possible solutions. Crit Rev Biotechnol 20:17.
4. Gomez R, Schnabel I, Garrido J. 1988. Pellet growth and citric acid yield of Aspergillus niger 110. Enzyme Microb Technol 10:188-191.
5. Gordon CL, Archer DB, eenes DJ, Doonan JH, Wells B, Trinci APJ, Robson GD. 2000a. A glucoamylase::GFP gene fusion to study protein secretion by individual hyphae of Aspergillus niger. J Microbiol Methods 42:39-48.
6. Jones MG. 2007. The first filamentous fungal genome sequences: Aspergillus leads the way for essential everyday resources or dusty museum specimens? Microbiology 153(Pt 1):1-6.
7. Kaup BA, Ehrich K, Pescheck M, Schrader J. 2007. Microparticle-enhanced cultivation of filamentous microorganisms: Increased chloroperoxidase formation by Caldariomyces fumago as an example. Biotech Bioeng 99:198-491. (Pubitemid 351158246)
8. Kelly S, Grimm LH, Hengstler J, Schultheis E, Krull R, Hempel DC. 2004. Agitation effects on submerged growth and product formation of Aspergillus niger. Bioprocess Biosyst Eng 26:315-323.
9. Mattern IE, Johannes MV, Van den Berg P, Archer DB, Roberts IN, an den Honde CAMJJ. 1992. Isolation and characterization of mutants of Aspergillus niger deficient in extracellular proteases. Mol Gen Genet 234:332-336.
10. McIntyre M, Muller C, Dyneson J, Nielsen J. 2001. Metabolic engineering of the morphology of Aspergillus. Adv Biochem Eng Biotechnol 73:103-128.
11. Metz B. 1976. From pulp to pellet. PhD Thesis. Delft Technical University of The Netherlands.
12. Miller GL. 1959. Use of dinitrosalicylic acid reagent for determination of reducing sugar. Anal Chem 31:426-428.
13. Mussatto SI, Rodrigues LR, Teixeira JA. 2009. Beta-fructofuranosidase production by repeated batch fermentation with immobilized Aspergillus japonicus. J Ind Microbiol Biotechnol 36(7):923-928.
14. Nielsen J. 1996. Modelling the morphology of filamentous microorganisms. Tibetch 14:438-443.
15. Papagianni M, Mattey M. 2006. Morphological development of Aspergillus niger in submerged citric acid fermentation as a function of the spore inoculum level. Application of neural network and cluster analysis for characterization of mycelial morphology. Microb Cell 5:3-12.
16. Petzoldt K. 1971. Mischfermentation von zwei steroid-umwandelnden Mikroorganismen. Chem Ing Tech 43:1-2.
17. Teng Y, Xu Y, Wang D. 2009. Changes in morphology of Rhizopus chinensis in submerged fermentation and their effect on production of mycelium-bound lipase. Bioprocess Biosyst Eng 32:397-405.
18. Van Hartingsveldt W, Mattern IE, Van Zeijl CM, Pouwels PH, Van den Hondel CA. 1987. Development of a homologous transformation system for Aspergillus niger based on the pyrG gene. Mol Gen Genet 206:71-75. (Pubitemid 17014167)
19. Vecht-Lifshitz SE, Magdassi S, Braun S. 1990. Pellet formation and cellular aggregation in Streptomyces tendae. Biotechnol Bioeng 35:890-896. (Pubitemid 20261484)
20. Vinck A, Terlou M, Pestman wR, Martens EP, Ram AF, van den Hondel CAMJJ, Wösten HAB. 2005. Hyphal differentiation in the exploring mycelium of Aspergillus niger. Mol Microbiol 58:693-699.
21. Wang L, Ridgway D, Gu T, Moo-Young M. 2005. Bioprocessing strategies to improve heterologous protein production in filamentous fungal fermentations. Biotechnol Adv 23:115-129. (Pubitemid 41512108)
22. Withers JM, Swift RJ, Wiebe MG, Robson GD, Punt PJ, van den Hondel CAMJJ, Trinci APJ. 1978. Optimization and stability of glucoamylase production by recombinant strains of Aspergillus niger in chemostat culture. Biotechnol Bioeng 59:407-418.
23. Wittler R, Baumgartl H, Lubbers D, Schugerl K. 1986. Investigations of oxygen transfer into Penicillium chrysogenum pellets by microprobe measurements. Biotechnol Bioeng 28:1024-1036. (Pubitemid 16588535)
24. Zhang ZY, Jin B, Kelly JM. 2007. Effects of cultivation parameters on the morphology of Rhizopus arrhizus and the lactic acid production in a bubble column reactor. Eng Life Sci 7:490-496.
25. Znidarsic P, Pavko A. 2001. The morphology of filamentous fungi in submerged cultivations as a bioprocess parameter. Morphology of filamentous fungi. Food Technol Biotechnol 39:237-252.
26. Zuccaro A, Götze S, Kneip S, Dersch P, Seibel J. 2008. Tailor-made fructooligosaccharides by a combination of substrate and genetic engineering. ChemBioChem 9:143-149.