Effect of liposomal transfection of UCH-L1 siRNA on proliferation and apoptosis of lung cancer cell line H157

Chinese Journal of Lung Cancer

Volumn 13, Issue 4, 2010, Pages 292-296

  Qu, Xiaojie ^a   Wang, Yanfu ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Lung neoplasms; siRNA; Ubiquitin C terminal hydrolase L1

Indexed keywords

MESSENGER RNA; SMALL INTERFERING RNA; UBIQUITIN C TERMINAL HYDROLASE L1; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; CELL STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; LIPOSOMAL GENE DELIVERY SYSTEM; LUNG ADENOCARCINOMA;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE THERAPY; HUMANS; LIPOSOMES; LUNG NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; UBIQUITIN THIOLESTERASE;

EID: 77951544473     PISSN: 10093419     EISSN: 19996187     Source Type: Journal    
DOI: 10.3779/j.issn.1009-3419.2010.04.04     Document Type: Article

References (19)

1. Hibi K, Westra WH, Borges M, et al. PGP9.5 as a candidate tumor marker for non-small cell lung cancer. Am J Pathol, 1999, 155(3): 711-715.
2. Yamashita K, Park HL, Kim MS, et al. PGP9.5 methylation in diffuse type gastric cancer. Cancer Res, 2006, 66(7): 3921-3927.
3. Mandelker DL, Yamashita K, Tokumaru Y, et al. PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma. Cancer Res, 2005, 65(11): 4963-4968.
4. Yamazaki T, Hibi K, Takase T, et al. PGP9.5 as a marker for invasive colorectal cancer. Clin Cancer Res, 2002, 8(1): 192-195.
5. Takano T, Miyauchi A, Matsuzuka F, et al. PGP9.5 mRNA could contribute to the molecular-based diagnosis of medullary thyroid carcinoma. Eur J Cancer, 2004, 40(4): 614-618.
6. Takase T, Hibi K, Yamazaki T, et al. PGP9.5 over expression in esophageal squamous cell carcinoma. Hepatogastroenterology, 2003, 50(53): 1278-1280.
7. Burger AM, Seth AK. The ubiquitin mediatedprotein degradation pathway in cancer: therapeutic implications. Eur J Cancer, 2004, 40(15): 2217-2229.
8. Otsuki T, Yata K, Takata-Tomokuni A, et al. Expression of protein gene product 9.5 (PGP 9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells. Br J Haematol, 2004, 127(3): 292-298.
9. Miyoshi Y, Nakayama S, Torikoshi Y, et al. High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer. Cancer Sci, 2006, 97(6): 523-529. (Pubitemid 43811594)
10. Tezel E, Hibi K, Nagasaka T, et al. PGP9.5 as a prognostic factor in pancreatic cancer. Clin Cancer Res, 2000, 6(12): 4764-4767.
11. Tanaka T, Kuramitsu Y, Fujimoto M, et al. Downregulation of two isoforms of ubiquitin carboxyl-terminal hydrolase isozyme L1 correlates with high metastatic potentials of human SN12C renal cell carcinoma cell clones. Electrophoresis, 2008, 29(12): 2651-2659.
12. Bittencourt Rosas SL, Caballero OL, Dong SM, et al. Methylation status in the promoter region of the human PGP9.5 gene in cancer and normal tissues. Cancer Lett, 2001, 170(1): 73-79.
13. Sasaki H, Yukiue H, Moriyama S, et al. Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer. Jpn J Clin Oncol, 2001, 31(11): 532-535.
14. Cejka D, Losert D, Wacheck V. Short interfering RNA (siRNA): tool or therapeutic? Clin Sci (Lond), 2006, 110: 47-58.
15. Wang WJ, Li QQ, Xu JD, et al. Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells. Int J Oncol, 2008, 33(5): 1037-1045.
16. Rolén U, Freda E, Xie J, et al. The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation. J Cell Mol Med, 2008 [Epub ahead of print].
17. Bheda A, Shackelford J, Pagano JS, et al. Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes. Plos One, 2009, 4(8): e6764.
18. Kim HJ, Kim YM, Lim S, et al. Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis. Oncogene, 2009, 28(1): 117-127
19. Liu Y, Lashuel HA, Choi S, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol, 2003, 10(9): 837-846.