Hyperoxia inhibits protein synthesis and increases eIF2α phosphorylation in the newborn rat lung

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 298, Issue 5, 2010, Pages

  Konsavage, Wesley ^a   Zhang, Lianqin ^a   Vary, Thomas ^a   Shenberger, Jeffrey S ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Bronchopulmonary dysplasia; Eukaryotic initiation factors; Lung injury; Mammalian target of rapamycin; mRNA translation; Oxygen toxicity

Indexed keywords

INITIATION FACTOR 2ALPHA; INITIATION FACTOR 4E BINDING PROTEIN; INITIATION FACTOR 4F; INITIATION FACTOR 4G; MAMMALIAN TARGET OF RAPAMYCIN; OXYGEN; PHENYLALANINE; RNA;

AMBIENT AIR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL SPECIFICITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HYPEROXIA; LUNG FIBROBLAST; LUNG WEIGHT; NEWBORN; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT;

ANIMALS; ANIMALS, NEWBORN; CELL LINE; DISEASE MODELS, ANIMAL; EUKARYOTIC INITIATION FACTOR-2; EUKARYOTIC INITIATION FACTOR-4F; FEMALE; FIBROBLASTS; HUMANS; HYPEROXIA; LUNG; PHOSPHORYLATION; PNEUMOCYTES; POLYRIBOSOMES; PREGNANCY; PROTEIN BIOSYNTHESIS; PROTEIN MULTIMERIZATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 77951525540     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00262.2009     Document Type: Article

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