ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion

Journal of Nutritional Biochemistry

Volumn 21, Issue 5, 2010, Pages 451-456

  Shichiri, Mototada ^a,b,c   Takanezawa, Yasukazu ^a   Rotzoll, Daisy E ^d   Yoshida, Yasukazu ^b   Kokubu, Tomokuni ^b   Ueda, Kazumitsu ^e,f   Tamai, Hiroshi ^c   Arai, Hiroyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c OSAKA MEDICAL COLLEGE   (Japan)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e KYOTO UNIVERSITY   (Japan)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

Tocopherol; Tocopherol transfer protein ( TTP); Apolipoprotein A I (apoA I); ATP Binding cassette transporter A1 (ABCA1); Hepatocyte; Probucol

Indexed keywords

ABC TRANSPORTER A1; ALPHA TOCOPHEROL; ALPHA TOCOPHEROL TRANSFER PROTEIN; APOLIPOPROTEIN A1; CARRIER PROTEIN; PROBUCOL; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL TRANSPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER FUNCTION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; RAT; RNA INTERFERENCE; STABLE EXPRESSION; VITAMIN BLOOD LEVEL;

ALPHA-TOCOPHEROL; ANIMALS; ANTICHOLESTEREMIC AGENTS; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; CARRIER PROTEINS; CELL LINE, TUMOR; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL; PROBUCOL; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TIME FACTORS;

EID: 77951499292     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.02.002     Document Type: Article

References (30)

1. Traber M.G. Determinants of plasma vitamin E concentrations. Free Radic Biol Med 1994, 16:229-239.
2. Burton G.W., Traber M.G. Vitamin E: antioxidant activity, biokinetics, and bioavailability. Annu Rev Nutr 1990, 10:357-382.
3. Kayden H.J., Traber M.G. Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. J Lipid Res 1993, 34:343-358.
4. Traber M.G., Sies H. Vitamin E in humans: demand and delivery. Annu Rev Nutr 1996, 16:321-347.
5. Bjorneboe A., Bjorneboe G.E., Bodd E., Hagen B.F., Kveseth N., Drevon C.A. Transport and distribution of alpha-tocopherol in lymph, serum and liver cells in rats. Biochim Biophys Acta 1986, 889:310-315.
6. Lee-Kim Y.C., Meydani M., Kassarjian Z., Blumberg J.B., Russell R.M. Enterohepatic circulation of newly administered alpha-tocopherol in the rat. Int J Vitam Nutr Res 1988, 58:284-291.
7. Traber M.G., Burton G.W., Ingold K.U., Kayden H.J. RRR- and SRR-alpha-tocopherols are secreted without discrimination in human chylomicrons, but RRR-alpha-tocopherol is preferentially secreted in very low density lipoproteins. J Lipid Res 1990, 31:675-685.
8. Meydani M., Martin K.R. Intestinal absorption of fat-soluble vitamins. Intestinal Lipid Metabolism 2001, 367-381. Kluwer Academic/Plenum Publishers, New York. C.M. Mansbach, P. Tso, A. Kuksis (Eds.).
9. Anwar K., Kayden H.J., Hussain M.M. Transport of vitamin E by differentiated Caco-2 cells. J Lipid Res 2006, 47:1261-1273.
10. Traber M.G., Goldberg I., Davidson E., Lagmay N., Kayden H.J. Vitamin E uptake by human intestinal cells during lipolysis in vitro. Gastroenterology 1990, 98:96-103.
11. Parker R.S., Sontag T.J., Swanson J.E., McCormick C.C. Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism. Ann N Y Acad Sci 2004, 1031:13-21.
12. Sontag T.J., Parker R.S. Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J Biol Chem 2002, 277:25290-25296.
13. Yokota T., Igarashi K., Uchihara T., Jishage K., Tomita H., Inaba A., et al. Delayed-onset ataxia in mice lacking alpha-tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress. Proc Natl Acad Sci U S A 2001, 98:15185-15190.
14. Morley S., Panagabko C., Shineman D., Mani B., Stocker A., Atkinson J., et al. Molecular determinants of heritable vitamin E deficiency. Biochemistry 2004, 43:4143-4149.
15. Arita M., Nomura K., Arai H., Inoue K. Alpha-tocopherol transfer protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway. Proc Natl Acad Sci U S A 1997, 94:12437-12441.
16. Qian J., Morley S., Wilson K., Nava P., Atkinson J., Manor D. Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein. J Lipid Res 2005, 46:2072-2082.
17. Oram J.F., Vaughan A.M., Stocker R. ATP-Binding cassette transporter A1 mediates cellular secretion of α-tocopherol. J Biol Chem 2001, 276:39898-39902.
18. Bodzioch M., Orsó E., Klucken J., Langmann T., Böttcher A., Diederich W., et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nature Genet 1999, 22:347-351.
19. Brooks-Wilson A., Marcil M., Clee S.M., Zhang L.H., Roomp K., van Dam M., et al. Mutation in ABC1 in Tangier disease and familial high density lipoprotein deficiency. Nature Genet 1999, 22:336-345.
20. Rust S., Rosier M., Funke H., Real J., Amoura Z., Piette J.C., et al. Tangier disease is caused by mutation in the gene encoding ATP-binding cassette transporter 1. Nature Genet 1999, 22:352-355.
21. Orso E., Bronccardo C., Kaminski W.E., Bottcher A., Liebish G., Drobnik W., et al. Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and Abc1-deficient mice. Nature Genet 2000, 24:192-196.
22. Munehira Y., Ohnishi T., Kawamoto S., Furuya A., Shitara K., Imamura M., et al. Alpha 1-syntrophin modulates turnover of ABCA1. J Biol Chem 2004, 279:15091-15095.
23. Gotoh N., Shimizu K., Komuro E., Tsuchiya J., Noguchi N., Niki E. Antioxidant activities of probucol against lipid peroxidations. Biochim Biophys Acta 1992, 1128:147-154.
24. Kuzuya M., Kuzuya F. Probucol as an antioxidant and antiatherogenic drug. Free Radic Biol Med 1993, 14:67-77.
25. Carew T.E., Schwenke D.C., Steinberg D. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci U S A 1987, 84:7725-7729.
26. Wu C.A., Tsujita M., Hayashi M., Yokoyama S. Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation. J Biol Chem 2004, 279:30168-30174.
27. Favari E., Zanotti I., Zimetti F., Ronda N., Bernini F., Rothblat G.H. Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler Thromb Vasc Biol 2004, 24(12):2345-2350.
28. Elinder L.S., Hådell K., Johansson J., Mølgaard J., Holme I., Olsson A.G., et al. Probucol treatment decreases serum concentrations of diet-derived antioxidants. Arterioscler Thromb Vasc Biol 1995, 15:1057-1063.
29. Bird D.A., Tangirala R.K., Fruebis J., Steinberg D., Witztum J.L., Palinski W. Effect of probucol on LDL oxidation and atherosclerosis in LDL receptor-deficient mice. J Lipid Res 1998, 39:1079-1090.
30. Choy K., Beck K., Png F.Y., Wu B.J., Leichtweis S.B., Thomas S.R., et al. Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice. Arterioscler Thromb Vasc Biol 2005, 25:1684-1690.