Water-solvent partition coefficients and Δ log P values as predictors for blood-brain distribution; application of the akaike information criterion

Journal of Pharmaceutical Sciences

Volumn 99, Issue 5, 2010, Pages 2492-2501

  Abraham, Michael H ^a   Acree Jr , William E ^b   Leo, Albert J ^c   Hoekman, David ^d   Cavanaugh, Joseph E ^e  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF NORTH TEXAS   (United States)

^c BioByte Corp   (United States)

^d David Hoekman Consulting Inc   (United States)

^e UNIVERSITY OF IOWA   (United States)

Author keywords

Akaike information criterion; Blood brain distribution; Linear free energy relationship; Water solvent partition coefficients; log P

Indexed keywords

ALKANE; CARBOXYLIC ACID; CHLOROFORM; CYCLOHEXANE; DODECANE; HEXADECANE; SOLVENT; VOLATILE AGENT; WATER;

ANALYTIC METHOD; ARTICLE; BLOOD BRAIN BARRIER; CHEMICAL ANALYSIS; CONTROLLED STUDY; MODEL; PARTITION COEFFICIENT; PREDICTION;

EID: 77951272176     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22010     Document Type: Article

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