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Volumn 396, Issue 7, 2010, Pages 2533-2542
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Design of experiments, a powerful tool for method development in forensic toxicology: Application to the optimization of urinary morphine 3-glucuronide acid hydrolysis
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Author keywords
Acid hydrolysis; Design of experiments; Forensic toxicology; Morphine 3 glucuronide
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Indexed keywords
ACID HYDROLYSIS;
CENTRAL COMPOSITE DESIGNS;
EXPERIMENTAL DATA;
FORENSIC TOXICOLOGY;
FULL FACTORIAL DESIGN;
GAS CHROMATOGRAPHY-MASS SPECTROMETRY;
GLUCURONIDES;
INDEPENDENT VARIABLES;
INTERNAL STANDARDS;
LIQUID-LIQUID EXTRACTION;
METHOD DEVELOPMENT;
MULTIPLE REGRESSION ANALYSIS;
ONE-FACTOR;
OPTIMUM COMBINATION;
PEAK AREA RATIOS;
RESPONSE SURFACE METHODOLOGY;
SECOND-ORDER POLYNOMIAL EQUATIONS;
SELECTED ION MONITORING;
SILYLATIONS;
URINE SAMPLE;
CHROMATOGRAPHIC ANALYSIS;
DESIGN OF EXPERIMENTS;
GAS CHROMATOGRAPHY;
HYDROLYSIS;
LIQUIDS;
MASS SPECTROMETRY;
OPTIMIZATION;
POLYNOMIALS;
REGRESSION ANALYSIS;
SOLVENT EXTRACTION;
ACIDS;
MORPHINE DERIVATIVE;
STREET DRUG;
ALGORITHM;
BLOOD;
CONFERENCE PAPER;
FORENSIC TOXICOLOGY;
HUMAN;
MASS SPECTROMETRY;
METHODOLOGY;
REPRODUCIBILITY;
RESEARCH;
SENSITIVITY AND SPECIFICITY;
SUBSTANCE ABUSE;
URINALYSIS;
URINE;
ALGORITHMS;
FORENSIC TOXICOLOGY;
HUMANS;
MASS SPECTROMETRY;
MORPHINE DERIVATIVES;
REPRODUCIBILITY OF RESULTS;
RESEARCH;
SENSITIVITY AND SPECIFICITY;
STREET DRUGS;
SUBSTANCE ABUSE DETECTION;
URINALYSIS;
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EID: 77951253925
PISSN: 16182642
EISSN: 16182650
Source Type: Journal
DOI: 10.1007/s00216-009-3447-8 Document Type: Conference Paper |
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Times cited : (36)
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References (33)
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