Treatment with fluoroquinolones or with β-lactam-β-lactamase inhibitor combinations is a risk factor for isolation of extended-spectrum- β-lactamase-producing klebsiella species in hospitalized patients

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 5, 2010, Pages 2010-2016

  Wener, Kenneth M ^a   Schechner, Vered ^b   Gold, Howard S ^c   Wright, Sharon B ^c   Carmeli, Yehuda ^b,c  

^a LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CARBAPENEM; CEPHALOSPORIN; CLINDAMYCIN; COTRIMOXAZOLE; EXTENDED SPECTRUM BETA LACTAMASE; METRONIDAZOLE; PENICILLIN G; PIPERACILLIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

AGED; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATION; CASE CONTROL STUDY; COMORBIDITY; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HEALTH CARE FACILITY; HOSPITAL INFECTION; HOSPITAL PATIENT; HUMAN; INTENSIVE CARE UNIT; KIDNEY DISEASE; KLEBSIELLA; KLEBSIELLA INFECTION; LIVER DISEASE; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; PATIENT TRANSPORT; PHENOTYPE; PRIORITY JOURNAL; RISK FACTOR; TERTIARY HEALTH CARE;

AGED; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CASE-CONTROL STUDIES; CROSS INFECTION; DRUG THERAPY, COMBINATION; FEMALE; FLUOROQUINOLONES; HOSPITALIZATION; HUMANS; KLEBSIELLA; KLEBSIELLA INFECTIONS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 77951251859     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01131-09     Document Type: Article

References (57)

1. Anderson, D. J., J. J. Engemann, L. J. Harrell, Y. Carmeli, L. B. Reller, and K. S. Kaye. 2006. Predictors of mortality in patients with bloodstream infection due to ceftazidime-resistant Klebsiella pneumoniae. Antimicrob. Agents Chemother. 50:1715-1720.
2. Asensio, A., A. Oliver, P. Gonzalez-Diego, F. Baquero, J. C. Perez-Diaz, P. Ros, J. Cobo, M. Palacios, D. Lasheras, and R. Canton. 2000. Outbreak of a multiresistant Klebsiella pneumoniae strain in an intensive care unit: antibiotic use as risk factor for colonization and infection. Clin. Infect. Dis. 30:55-60.
3. Babini, G. S., and D. M. Livermore. 2000. Antimicrobial resistance amongst Klebsiella spp. collected from intensive care units in Southern and Western Europe in 1997-1998. J. Antimicrob. Chemother. 45:183-189.
4. Baquero, F., M. C. Negri, M. I. Morosini, and J. Blazquez. 1998. Antibiotic-selective environments. Clin. Infect. Dis. 27(Suppl. 1):S5-S11.
5. Ben-Ami, R., M. J. Schwaber, S. Navon-Venezia, D. Schwartz, M. Giladi, I. Chmelnitsky, A. Leavitt, and Y. Carmeli. 2006. Influx of extended-spectrum beta-lactamase-producing enterobacteriaceae into the hospital. Clin. Infect. Dis. 42:925-934.
6. Canton, R., M. I. Morosini, O. M. de la Maza, and E. G. de la Pedrosa. 2008. IRT and CMT beta-lactamases and inhibitor resistance. Clin. Microbiol. Infect. 14(Suppl. 1):53-62.
7. Canton, R., A. Novais, A. Valverde, E. Machado, L. Peixe, F. Baquero, and T. M. Coque. 2008. Prevalence and spread of extended-spectrum beta-lactamase- producing Enterobacteriaceae in Europe. Clin. Microbiol. Infect. 14(Suppl. 1):144-153.
8. Carmeli, Y., G. M. Eliopoulos, and M. H. Samore. 2002. Antecedent treatment with different antibiotic agents as a risk factor for vancomycin-resistant Enterococcus. Emerg. Infect. Dis. 8:802-807.
9. Centers for Disease Control and Prevention, National Nosocomial Surveillance System. 2004. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am. J. Infect. Control 32:470-485.
10. Chmelnitsky, I., Y. Carmeli, A. Leavitt, M. J. Schwaber, and S. Navon-Venezia. 2005. CTX-M-2 and a new CTX-M-39 enzyme are the major extended-spectrum beta-lactamases in multiple Escherichia coli clones isolated in Tel Aviv, Israel. Antimicrob. Agents Chemother. 49:4745-4750.
11. Colodner, R., W. Rock, B. Chazan, N. Keller, N. Guy, W. Sakran, and R. Raz. 2004. Risk factors for the development of extended-spectrum beta-lactamase-producing bacteria in nonhospitalized patients. Eur. J. Clin. Microbiol. Infect. Dis. 23:163-167.
12. Colodner, R., Z. Samra, N. Keller, H. Sprecher, C. Block, N. Peled, T. Lazarovitch, R. Bardenstein, O. Schwartz-Harari, and Y. Carmeli. 2007. First national surveillance of susceptibility of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. to antimicrobials in Israel. Diagn. Microbiol. Infect. Dis. 57:201-205.
13. Harbarth, S., A. D. Harris, Y. Carmeli, and M. H. Samore. 2001. Parallel analysis of individual and aggregated data on antibiotic exposure and resistance in gram-negative bacilli. Clin. Infect. Dis. 33:1462-1468.
14. Harris, A. D., T. B. Karchmer, Y. Carmeli, and M. H. Samore. 2001. Methodological principles of case-control studies that analyzed risk factors for antibiotic resistance: a systematic review. Clin. Infect. Dis. 32:1055-1061.
15. Harris, A. D., J. C. McGregor, J. A. Johnson, S. M. Strauss, A. C. Moore, H. C. Standiford, J. N. Hebden, and J. G. Morris, Jr. 2007. Risk factors for colonization with extended-spectrum beta-lactamase-producing bacteria and intensive care unit admission. Emerg. Infect. Dis. 13:1144-1149.
16. Harris, A. D., M. H. Samore, and Y. Carmeli. 2000. Control group selection is an important but neglected issue in studies of antibiotic resistance. Ann. Intern. Med. 133:159.
17. Harris, A. D., M. H. Samore, M. Lipsitch, K. S. Kaye, E. Perencevich, and Y. Carmeli. 2002. Control-group selection importance in studies of antimicrobial resistance: examples applied to Pseudomonas aeruginosa, enterococci, and Escherichia coli. Clin. Infect. Dis. 34:1558-1563.
18. Hoyen, C. K., N. J. Pultz, D. L. Paterson, D. C. Aron, and C. J. Donskey. 2003. Effect of parenteral antibiotic administration on establishment of intestinal colonization in mice by Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases. Antimicrob. Agents Chemother. 47:3610-3612.
19. Huang, Y., S. Zhuang, and M. Du. 2007. Risk factors of nosocomial infection with extended-spectrum beta-lactamase-producing bacteria in a neonatal intensive care unit in China. Infection 35:339-345.
20. Hyle, E. P., A. D. Lipworth, T. E. Zaoutis, I. Nachamkin, W. B. Bilker, and E. Lautenbach. 2005. Impact of inadequate initial antimicrobial therapy on mortality in infections due to extended-spectrum beta-lactamase-producing enterobacteriaceae: variability by site of infection. Arch. Intern. Med. 165: 1375-1380.
21. Kaye, K. S., A. D. Harris, M. Samore, and Y. Carmeli. 2005. The case-case-control study design: addressing the limitations of risk factor studies for antimicrobial resistance. Infect. Control Hosp. Epidemiol. 26:346-351.
22. Kaye, K. S., Z. A. Kanafani, A. E. Dodds, J. J. Engemann, S. G. Weber, and Y. Carmeli. 2006. Differential effects of levofloxacin and ciprofloxacin on the risk for isolation of quinolone-resistant Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 50:2192-2196.
23. Kim, J. Y., J. W. Sohn, D. W. Park, Y. K. Yoon, Y. M. Kim, and M. J. Kim. 2008. Control of extended-spectrum β-lactamase-producing Klebsiella pneumoniae using a computer-assisted management program to restrict thirdgeneration cephalosporin use. J. Antimicrob. Chemother. 62:416-421.
24. Kim, S. H., W. B. Park, C. S. Lee, C. I. Kang, J. W. Bang, H. B. Kim, N. J. Kim, E. C. Kim, M. D. Oh, and K. W. Choe. 2006. Outcome of inappropriate empirical antibiotic therapy in patients with Staphylococcus aureus bacteraemia: analytical strategy using propensity scores. Clin. Microbiol. Infect. 12:13-21.
25. Korten, V., and B. E. Murray. 1993. Impact of the fluoroquinolones on gastrointestinal flora. Drugs 45(Suppl. 3):125-133.
26. Landman, D., M. Chockalingam, and J. M. Quale. 1999. Reduction in the incidence of methicillin-resistant Staphylococcus aureus and ceftazidime-resistant Klebsiella pneumoniae following changes in a hospital antibiotic formulary. Clin. Infect. Dis. 28:1062-1066.
27. Lautenbach, E., J. P. Metlay, M. G. Weiner, W. B. Bilker, P. Tolomeo, X. Mao, I. Nachamkin, and N. O. Fishman. 2009. Gastrointestinal tract colonization with fluoroquinolone-resistant Escherichia coli in hospitalized patients: changes over time in risk factors for resistance. Infect. Control Hosp. Epidemiol. 30:18-24.
28. Lautenbach, E., J. B. Patel, W. B. Bilker, P. H. Edelstein, and N. O. Fishman. 2001. Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomes. Clin. Infect. Dis. 32:1162-1171.
29. Lautenbach, E., B. L. Strom, W. B. Bilker, J. B. Patel, P. H. Edelstein, and N. O. Fishman. 2001. Epidemiological investigation of fluoroquinolone resistance in infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae. Clin. Infect. Dis. 33:1288-1294.
30. Lee, S. O., E. S. Lee, S. Y. Park, S. Y. Kim, Y. H. Seo, and Y. K. Cho. 2004. Reduced use of third-generation cephalosporins decreases the acquisition of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae. Infect. Control Hosp. Epidemiol. 25:832-837.
31. Lin, M. F., M. L. Huang, and S. H. Lai. 2003. Risk factors in the acquisition of extended-spectrum beta-lactamase Klebsiella pneumoniae: a case-control study in a district teaching hospital in Taiwan. J. Hosp. Infect. 53:39-45.
32. Navon-Venezia, S., I. Chmelnitsky, A. Leavitt, and Y. Carmeli. 2008. Dissemination of the CTX-M-25 family beta-lactamases among Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae and identification of the novel enzyme CTX-M-41 in Proteus mirabilis in Israel. J. Antimicrob. Chemother. 62:289-295.
33. Neuhauser, M. M., R. A. Weinstein, R. Rydman, L. H. Danziger, G. Karam, and J. P. Quinn. 2003. Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use. JAMA 289: 885-888.
34. Paterson, D. L. 2004. "Collateral damage" from cephalosporin or quinolone antibiotic therapy. Clin. Infect. Dis. 38(Suppl. 4):S341-S345.
35. Paterson, D. L. 2002. Looking for risk factors for the acquisition of antibiotic resistance: a 21st-century approach. Clin. Infect. Dis. 34:1564-1567.
36. Paterson, D. L., and R. A. Bonomo. 2005. Extended-spectrum beta-lactamases: a clinical update. Clin. Microbiol. Rev. 18:657-686.
37. Paterson, D. L., W. C. Ko, A. Von Gottberg, S. Mohapatra, J. M. Casellas, H. Goossens, L. Mulazimoglu, G. Trenholme, K. P. Klugman, R. A. Bonomo, L. B. Rice, M. M. Wagener, J. G. McCormack, and V. L. Yu. 2004. Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases. Clin. Infect. Dis. 39:31-37.
38. Paterson, D. L., W. C. Ko, A. Von Gottberg, S. Mohapatra, J. M. Casellas, H. Goossens, L. Mulazimoglu, G. Trenholme, K. P. Klugman, R. A. Bonomo, L. B. Rice, M. M. Wagener, J. G. McCormack, and V. L. Yu. 2004. International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial infections. Ann. Intern. Med. 140:26-32.
39. Paterson, D. L., L. Mulazimoglu, J. M. Casellas, W. C. Ko, H. Goossens, A. Von Gottberg, S. Mohapatra, G. M. Trenholme, K. P. Klugman, J. G. McCormack, and V. L. Yu. 2000. Epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum beta-lactamase production in Klebsiella pneumoniae isolates causing bacteremia. Clin. Infect. Dis. 30:473-478.
40. Patterson, J. E., T. C. Hardin, C. A. Kelly, R. C. Garcia, and J. H. Jorgensen. 2000. Association of antibiotic utilization measures and control of multipledrug resistance in Klebsiella pneumoniae. Infect. Control Hosp. Epidemiol. 21:455-458.
41. Pena, C., C. Gudiol, L. Calatayud, F. Tubau, M. A. Dominguez, M. Pujol, J. Ariza, and F. Gudiol. 2008. Infections due to Escherichia coli producing extended-spectrum beta-lactamase among hospitalised patients: factors influencing mortality. J. Hosp. Infect. 68:116-122.
42. Pitout, J. D., and K. B. Laupland. 2008. Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect. Dis. 8:159-166.
43. Quale, J. M., D. Landman, P. A. Bradford, M. Visalli, J. Ravishankar, C. Flores, D. Mayorga, K. Vangala, and A. Adedeji. 2002. Molecular epidemiology of a citywide outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae infection. Clin. Infect. Dis. 35:834-841.
44. Rahal, J. J., C. Urban, D. Horn, K. Freeman, S. Segal-Maurer, J. Maurer, N. Mariano, S. Marks, J. M. Burns, D. Dominick, and M. Lim. 1998. Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. JAMA 280:1233-1237.
45. Reeves, D. S. 1986. The effect of quinolone antibacterials on the gastrointestinal flora compared with that of other antibacterials. J. Antimicrob. Chemother. 18(Suppl. D):89-102.
46. Rice, L. B., E. C. Eckstein, J. DeVente, and D. M. Shlaes. 1996. Ceftazidimeresistant Klebsiella pneumoniae isolates recovered at the Cleveland Department of Veterans Affairs Medical Center. Clin. Infect. Dis. 23:118-124.
47. Rodriguez-Bano, J., M. D. Navarro, L. Romero, M. A. Muniain, M. Cueto, J. Galvez, E. J. Perea, and A. Pascual. 2008. Risk-factors for emerging bloodstream infections caused by extended-spectrum beta-lactamase-producing Escherichia coli. Clin. Microbiol. Infect. 14:180-183.
48. Rubin, D. B. 1997. Estimating causal effects from large data sets using propensity scores. Ann. Intern. Med. 127:757-763.
49. Schwaber, M. J., S. Navon-Venezia, K. S. Kaye, R. Ben-Ami, D. Schwartz, and Y. Carmeli. 2006. Clinical and economic impact of bacteremia with extended-spectrum-beta-lactamase-producing Enterobacteriaceae. Antimicrob. Agents Chemother. 50:1257-1262.
50. Schwaber, M. J., S. Navon-Venezia, D. Schwartz, and Y. Carmeli. 2005. High levels of antimicrobial coresistance among extended-spectrum-beta- lactamase- producing Enterobacteriaceae. Antimicrob. Agents Chemother. 49: 2137-2139.
51. Steward, C. D., J. K. Rasheed, S. K. Hubert, J. W. Biddle, P. M. Raney, G. J. Anderson, P. P. Williams, K. L. Brittain, A. Oliver, J. E. McGowan, Jr., and F. C. Tenover. 2001. Characterization of clinical isolates of Klebsiella pneumoniae from 19 laboratories using the National Committee for Clinical Laboratory Standards extended-spectrum beta-lactamase detection methods. J. Clin. Microbiol. 39:2864-2872.
52. Stone, S. P., B. S. Cooper, C. C. Kibbler, B. D. Cookson, J. A. Roberts, G. F. Medley, G. Duckworth, R. Lai, S. Ebrahim, E. M. Brown, P. J. Wiffen, and P. G. Davey. 2007. The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection. Lancet Infect. Dis. 7:282-288.
53. Tumbarello, M., M. Sanguinetti, E. Montuori, E. M. Trecarichi, B. Posteraro, B. Fiori, R. Citton, T. D'Inzeo, G. Fadda, R. Cauda, and T. Spanu. 2007. Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob. Agents Chemother. 51:1987-1994.
54. Turner, P. J. 2005. Extended-spectrum beta-lactamases. Clin. Infect. Dis. 41(Suppl. 4):S273-S275.
55. Wiener, J., J. P. Quinn, P. A. Bradford, R. V. Goering, C. Nathan, K. Bush, and R. A. Weinstein. 1999. Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes. JAMA 281:517-523.
56. World Health Organization. 1977. Manual of international statistical classification of diseases, injuries, and causes of death, vol. 1. World Health Organization, Geneva, Switzerland.
57. Zimhony, O., I. Chmelnitsky, R. Bardenstein, S. Goland, O. Hammer Muntz, S. Navon Venezia, and Y. Carmeli. 2006. Endocarditis caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: emergence of resistance to ciprofloxacin and piperacillin-tazobactam during treatment despite initial susceptibility. Antimicrob. Agents Chemother. 50:3179-3182.