Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation

Journal of Biological Chemistry

Volumn 285, Issue 16, 2010, Pages 11948-11957

  Luscieti, Sara ^a   Santambrogio, Paolo ^b   D'Estaintot, Béatrice Langlois ^c   Granier, Thierry ^c   Cozzi, Anna ^b   Poli, Maura ^a   Gallois, Bernard ^c   Finazzi, Dario ^a,d   Cattaneo, Angela ^b   Levi, Sonia ^b,e   Arosio, Paolo ^a,d  

^a UNIVERSITY OF BRESCIA   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c CNRS   (France)

^d Spedali Civili di Brescia   (Italy)

^e VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN IRON; C TERMINUS; CRYSTALLOGRAPHIC CHARACTERIZATION; DATA SUPPORT; FERRITIN IRON; HETEROPOLYMERS; IN-VITRO; LIGHT CHAIN; MOVEMENT DISORDERS; NEURODEGENERATION; NEURODEGENERATIVE; PATHOGENIC MUTATION; PHYSICAL STABILITY; STABILITY PROPERTIES;

ESCHERICHIA COLI; IRON COMPOUNDS; STABILITY;

LIGHT TRANSMISSION;

ASCORBIC ACID; FERRITIN; FERRITIN LIGHT CHAIN; ISOFERRITIN; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DEGENERATIVE DISEASE; ESCHERICHIA COLI; GENE MUTATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; APOFERRITINS; CRYSTALLOGRAPHY, X-RAY; GENES, DOMINANT; HUMANS; HYDROPHOBICITY; IRON; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NERVE DEGENERATION; PROTEIN CONFORMATION; PROTEIN STABILITY; RECOMBINANT PROTEINS; SEQUENCE DELETION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STATIC ELECTRICITY;

ESCHERICHIA COLI;

EID: 77951249355     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.096404     Document Type: Article

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