IFN-β reverses the lipopolysaccharide-induced proteome modifications in treated astrocytes

Journal of Neuroimmunology

Volumn 221, Issue 1-2, 2010, Pages 115-120

  Vergara, Daniele ^a   Martignago, Roberta ^a   Bonsegna, Stefania ^b   De Nuccio, Francesco ^a   Santino, Angelo ^b   Nicolardi, Giuseppe ^a   Maffia, Michele ^a,c  

^a UNIVERSITY OF SALENTO   (Italy)

^b INSTITUTE OF SCIENCES OF FOOD PRODUCTION   (Italy)

^c ASL Lecce   (Italy)

Author keywords

2 DE; Astrocytes; Interferon ; Lipopolysaccharide; Multiple sclerosis

Indexed keywords

BETA INTERFERON; LIPOPOLYSACCHARIDE; PROTEOME; SUPEROXIDE DISMUTASE; CYTOKINE; IMMUNOLOGIC FACTOR;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL PROTECTION; CELL STIMULATION; CONTROLLED STUDY; CYTOSKELETON; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; MICROGLIA; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN MODIFICATION; RAT; ANIMAL; CELL CULTURE; DRUG EFFECT; DRUG INTERACTION; GENE EXPRESSION REGULATION; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; TWO DIMENSIONAL GEL ELECTROPHORESIS; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELLS, CULTURED; CYTOKINES; DRUG INTERACTIONS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION REGULATION; IMMUNOLOGIC FACTORS; INTERFERON-BETA; LIPOPOLYSACCHARIDES; PROTEOME; RATS; RATS, WISTAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 77951247082     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.01.002     Document Type: Article

References (25)

1. Barca O., Ferre' S., Seoane M., Prieto J.M., Lema M., Señarís R., Arce V.M. Interferon beta promotes survival in primary astrocytes through phosphatidylinositol 3-kinase. J. Neuroimmunol. 2003, 139:155-159.
2. Barca O., Seoane M., Ferré S., Prieto J.M. Mechanisms of interferon-β-induced survival in fetal and neonatal primary astrocytes. Neuroimmunomodulation 2007, 14:39-45.
3. Barca O., Costoya J.A., Señarís R.M., Arce V.M. Interferon-β protects astrocytes against tumour necrosis factor-induced apoptosis via activation of p38 mitogen-activated protein kinase. Exp. Cell Res. 2008, 314:2231-2237.
4. Barna B.P., Chou S.M., Jacobs B., Yen-Lieberman B., Ransohoff R.M. Interferon-beta impairs induction of HLA-DR antigen expression in cultured adult human astrocytes. J. Neuroimmunol. 1989, 23:45-53.
5. Chakravortty D., Nanda Kumar K.S. Bacterial lipopolysaccharide induces cytoskeletal rearrangement in small intestinal lamina propria fibroblasts: actin assembly is essential for lipopolysaccharide signalling. Biochim. Biophys. Acta 2000, 1500:125-136.
6. De Masi R., Vergara D., Pasca S., Acierno R., Greco M., Spagnolo L., Blasi E., Sanapo F., Trianni G., Maffia M. PBMCs protein expression profile in relapsing IFN-treated multiple sclerosis: a pilot study on relation to clinical findings and brain atrophy. J. Neuroimmunol. 2009, 210:80-86.
7. Dong Y., Benveniste E.N. Immune function of astrocytes. Glia 2001, 36:180-190.
8. Guo B., Chang E.Y., Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest. 2008, 118:1680-1690.
9. Guthikonda P., Baker J., Mattson D.H. Interferon-beta-1-b (IFN-B) decreases induced nitric oxide (NO) production by a human astrocytoma cell line. J. Neuroimmunol. 1998, 82:133-139. (7).
10. Hamamcioglu K., Reder A.T. Interferon-beta regulates cytokines and BDNF: greater effect in relapsing than in progressive multiple sclerosis. Mult. Scler. 2007, 13:459-470.
11. Kappos L., Traboulsee A., Constantinescu C., Erälinna J.P., Forrestal F., Jongen P., Pollard J., Sandberg-Wollheim M., Sindic C., Stubinski B., Uitdehaag B., Li D. Long-term subcutaneous interferon beta-1a therapy in patients with relapsing-remitting MS. Neurology 2006, 67:944-953.
12. Malik O., Compston D.A., Scolding N.J. Interferon-beta inhibits mitogen induced astrocyte proliferation in vitro. J. Neuroimmunol. 1998, 86:155-162.
13. McCarthy K.D., de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 1980, 85:890-902.
14. McNaught K.S.P., Jenner P. Extracellular accumulation of nitric oxide, hydrogen peroxide, and glutamate in astrocytic cultures following glutathione depletion, complex I inhibition, and/or lipopolysaccharide-induced activation. Biochem. Pharmacol. 2000, 60:979-988.
15. Miljkovic D., Momcilovic M., Stojanovic I., Stosic-Grujicic S., Ramic Z., Mostarica-Stojkovic M. Astrocytes stimulate interleukin-17 and interferon-β production in vitro. J. Neurosci. Res. 2007, 85:3598-3606.
16. Nair A., Frederick T.J., Miller S.D. Astrocytes in multiple sclerosis: a product of their environment. Cell. Mol. Life Sci. 2008, 65:2702-2720.
17. Satoh J., Kuroda Y. Differing effects of IFN beta vs. IFN gamma in MS: gene expression in cultured astrocytes. Neurology 2001, 57:681-685.
18. Satoh J., Paty D.W., Kim S.U. Counteracting effect of IFN-beta on IFN-gamma-induced proliferation of human astrocytes in culture. Mult. Scler. 1996, 1:279-287.
19. Stewart V.C., Giovannoni G., Land J.M., McDonald W.I., Clark J.B., Heales S.J. Pretreatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase. J. Neurochem. 1997, 68:2547-2551.
20. Stewart V.C., Land J.M., Clark J.B., Heales S.J. Pretreatment of astrocytes with interferon-alpha/beta prevents neuronal mitochondrial respiratory chain damage. J. Neurochem. 1998, 70:432-434.
21. Tedeschi B., Barrett J.N., Keane R.W. Astrocytes produce interferon that enhances the expression of H-2 antigens on a subpopulation of brain cells. J. Cell Biol. 1986, 102:2244-2253.
22. Trojano M., Pellegrini F., Fuiani A., Paolicelli D., Zipoli V., Zimatore G.B., Di Monte E., Portaccio E.V., Livrea P., Amato M.P. New natural history of interferon-beta-treated relapsing multiple sclerosis. Ann. Neurol. 2007, 61:300-306.
23. Vergara D., Chiriacò F., Acierno R., Maffia M. Proteomic map of peripheral blood mononuclear cells. Proteomics 2008, 8:2045-2051.
24. Vergara D., Martignago R., Leporatti S., Bonsegna S., Maruccio G., De Nuccio F., Santino A., Cingolani R., Nicolardi G., Maffia M., Rinaldi R. Biomechanical and proteomic analysis of INF-beta-treated astrocytes. Nanotechnology 2009, 20:455106.
25. Zanon R.G., Oliveira A.L. MHC I upregulation influences astroglial reaction and synaptic plasticity in the spinal cord after sciatic nerve transaction. Exp. Neurol. 2006, 200:521-531.