Childhood cancer near german nuclear power stations

Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews

Volumn 28, Issue 1, 2010, Pages 1-21

  Fairlie, Ian ^a  

^a NONE

Author keywords

Cancer; Carbon 14; Congenital malformations; Discharges; Embryo; Emissions; Fetus; Leukemia; Nuclear power stations; Radiation; Radioactivity; Radionuclides; Relative risk; Tritium

Indexed keywords

CARBON 14; CONGENITAL MALFORMATIONS; DISCHARGES; EMISSIONS; NUCLEAR POWER STATION; RELATIVE RISKS;

NUCLEAR PROPULSION; NUCLEAR REACTORS; RADIATION; RADIOACTIVITY; RADIOISOTOPES; RADIOMETRY; RADIOTHERAPY; TRITIUM;

NUCLEAR ENERGY;

ARGON; CARBON 14; KRYPTON; TRITIUM; XENON;

BIOACCUMULATION; CANCER EPIDEMIOLOGY; CANCER INCIDENCE; CANCER RISK; CHILDHOOD CANCER; CHILDHOOD LEUKEMIA; DOSIMETRY; EMBRYO DEVELOPMENT; EMBRYONAL CARCINOMA; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL RADIOACTIVITY; FETUS DEVELOPMENT; GERMANY; HEMATOPOIETIC TISSUE; HUMAN; NUCLEAR POWER PLANT; NUCLEAR REACTOR; PREGNANT WOMAN; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; RADIATION SAFETY; RADIOSENSITIVITY; REVIEW; RISK ASSESSMENT; TERATOGENICITY;

CHILD; GERMANY; HUMANS; NEOPLASMS; NUCLEAR POWER PLANTS;

EID: 77951236348     PISSN: 10590501     EISSN: 15324095     Source Type: Journal    
DOI: 10.1080/10590500903585366     Document Type: Review

References (62)

1. Committee on the Medical Aspects of Radiation in the Environment (COMARE). The implications of the new data on the releases from Sellafield in the 1950s for the possible increased incidence of cancer in west Cumbria. First report. London: Her Majesty's Stationery Office; 1986.
2. Committee on the Medical Aspects of Radiation in the Environment (COMARE). Investigation of the possible increased incidence of childhood cancer in young persons near the Dounreay nuclear establishment, Caithness, Scotland. Second report London: Her Majesty's Stationery Office; 1988.
3. Committee on the Medical Aspects of Radiation in the Environment (COMARE). Report on the incidence of childhood cancer in the West Berkshire and North Hampshire area which are situated the atomic weapons research establishment, Aldermaston and Royal Ordnance Factory, Burghfield. Third report. London: Her Majesty's Stationery Office; 1989.
4. Committee on the Medical Aspects of Radiation in the Environment (COMARE). The incidence of cancer and leukemias in young people in the vicinity of the Sellafield site, West Cumbria: further studies and an update of the situation since the publication of the report of the Black Advisory Group in 1984. Fourth report. London: Department of Health; 1996.
5. Kaatsch P, Spix C, Schulze-Rath R, Schmiedel S, Blettner M. Leukemias in young children living in the vicinity of German nuclear power plants. Int J Cancer 2008;122:721-726.
6. Spix C, Schmiedel S, Kaatsch P, Schulze-Rath R, Blettner M. Case-control study on childhood cancer in the vicinity of nuclear power plants in Germany 1980-2003. Eur J Cancer 2008;44:275-284.
7. Körblein A, Hoffmann W. Childhood cancer in the vicinity of German nuclear power plants. Medicine & Global Survival. 1999;6(1):18-23. Available at http://www.ippnw.org/Resources/MGS/V6N1Korblein.html
8. Weiss W. Background information on the KiKK study. German Federal Office for Radiation Protection 2007, Berlin,Germany. Available in German at http://www.bfs.de/en/kerntechnik/papiere/kikk.html
9. BfS. Unanimous Statement by the Expert Group commissioned by the Bundesamt fur Strahlenschutz on the KiKK Study. German Federal Office for Radiation Protection. Berlin, Germany; 2007. Available at http://www.bfs.de/ de/bfs/druck/Ufoplan/4334 KIKK Zusamm.pdf
10. Stewart A, Webb J, Hewitt D. A survey of childhood malignancies. British Medical Journal 1958;1:1495-1508.
11. Committee on the Biological Effects of Ionizing Radiations, National Research Council. Health effects of exposure to low levels of ionizing radiations. BEIR V Report. Washington, DC: National Academy Press; 1990.
12. Preston DL, Kusumi S, Tomonaga M, et al. Cancer incidence in atomic bomb survivors. III. Leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat Res 1994;137(Suppl):S68-S97. (Pubitemid 24060247)
13. International Agency for Research on Cancer. Monographs on the evaluation of carcinogenic risks to humans. I. X- and gamma radiation, and neutrons. Ionizing radiation. Volume 75. Lyon, France: IARC; 1999.
14. Forman D, Cook-Mozaffari P, Darby S, Davey G, Stratton I, Doll R, Pike M. Cancer near nuclear installations. Nature 1987, 329(6139):499-505. (Pubitemid 17043141)
15. Gardner MJ. Father's occupational exposure to radiation and the raised level of childhood leukemias near the Sellafield nuclear plant. Environ Health Perspect 1991;94:5-7.
16. Pobel D, Viel JF. Case-control study of leukemias among young people near La Hague nuclear reprocessing plant: the environmental hypothesis revisited. BMJ 1997, 314:101-106. (Pubitemid 27022950)
17. Laurier D, Bard D. Epidemiologic studies of leukemia among persons under 25 years of age living near nuclear sites. Epidemiol Rev 1999;21(2):188-206. (Pubitemid 30654785)
18. Guizard AV, Boutou O, Pottier D, Troussard X, Pheby D, Launoy G, Slama R, Spira A. The incidence of childhood leukemias around the La Hague nuclear waste reprocessing plant (France): a survey for the years 1978-1998. J Epidemiol Community Health 2001;55:469-474. (Pubitemid 32591899)
19. Hoffmann W, Terschueren C, Richardson DB. Childhood leukemias in the vicinity of the Geesthacht nuclear establishments near Hamburg, Germany. Environ Health Perspect 2007;115:947-952. Available at http://www.ehponline.org/ members/2007/9861/9861.pdf (Pubitemid 46902252)
20. Committee on the Medical Aspects of Radiation in the Environment (COMARE). The incidence of childhood cancer around nuclear installations in Great Britain. Tenth report. London: Health Protection Agency; 2005.
21. Committee on the Medical Aspects of Radiation in the Environment (COMARE). The distribution of childhood leukemias and other childhood cancer in Great Britain 1969-1993. Eleventh report. London: Health Protection Agency; 2006.
22. White-Koning ML, Hemon D, Laurier D, Tirmarche M, Jougla E, Goubin A, Clavel J. Incidence of childhood leukemias in the vicinity of nuclear sites in France, 1990-1998. Br J Cancer 2004;91:916-922. (Pubitemid 39273785)
23. Laurier D, Grosche B, Hall P. Risk of childhood leukemia in the vicinity of nuclear installations-findings and recent controversies. Acta Oncol 2002;41(1):14-24. (Pubitemid 34293354)
24. Bithell JT, Keegan TJ, Kroll ME, Murphy MFG, Vincent TJ. Childhood leukemia near British nuclear installations: methodological issues and recent results. Radiation Protection Dosimetry 2008;45:1-7.
25. Laurier D, H́emon D, Clavel J. Childhood leukemia incidence below the age of 5 years near French nuclear power plants. J Radiol Prot 2008, 28:401-403.
26. Sterne JAC, Smith GD. Sifting the evidence-what's wrong with significance tests? Phys Ther 2001;81(8):1464-1469.
27. Axelson O. Negative and non-positive epidemiological studies. Int J Occup Med Environ Health 2004;17:115-121. (Pubitemid 38480461)
28. Everett DC, Taylor S, Kafadar K. Fundamental concepts in statistics: Elucidation and illustration. J of Applied Physiology 1998, 85(3):775-786. (Pubitemid 28413251)
29. Whitley E, Ball J. Statistics review 1: Presenting and summarising data. Crit Care 2002;6:66-71. (Pubitemid 34162859)
30. Altman DG, Bland JM. Absence of evidence is not evidence of absence. BMJ 1995;311:485.
31. Baker PJ, Hoel D. Meta-analysis of standardized incidence and mortality rates of childhood leukemias in proximity to nuclear facilities. Eur J Cancer Care 2007;16:355-363.
32. Personal communication from Dr A Körblein.
33. Kaatsch P, Spix C, Jung I, Blettner M. Childhood leukemia in the vicinity of nuclear power plants in Germany. Deutsch Arztebl Int 2008;105(42): 725-732
34. Laurier D, Jacob S, Bernier MO, Leuraud K, Metz C, Samson E, Laloi P. Epidemiological studies of leukaemia in children and young adults around nuclear facilities: a critical review. Radiat Prot Dosimetry 2008;132(2):182-190
35. Bradford Hill A. The environment and disease: Association or causation? Proceedings of the Royal Society of Medicine 1965;58:295-300.
36. Crouch D. The role of predictive modelling: Social and scientific problems of radiation risk assessment. In Radiation and Health: The Biological Effects of Low-Level Exposure to Ionizing Radiation. Jones RR and Southwood R (Eds.). Chichester, UK: John Wiley and Sons; 1987:47-65.
37. Sumner D, Wheldon T,Watson D. Radiation Risks: An Evaluation. Whithorn, Scotland: Tarragon Press; 1994: 197.
38. Kinlen LJ. Childhood leukemia and population mixing. Pediatrics 2004;114(1):330-331.
39. Greaves M. Infection, immune responses and the aetiology of childhood leukemia. Nat Rev Cancer 2006;6(3):193-203. (Pubitemid 43292563)
40. Gardner MJ, Snee MP, Hall AJ, Powell CA, Downes S, Terrell JD. Results of casecontrol study of leukemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ 1990;300:423-429. (Pubitemid 20069261)
41. Koppe JG, Bartonova A, Bolte G, Bistrup ML, Busby C, Butter M, Dorfman P, Fucic A, Gee D, Van Den Hazel P, Howard V, Kohlhuber M, LeijsM, Lundqvist C,Moshammer H, Naginiene R , Nicolopoulou-Stamati P, Ronchetti R, Salines G, Schoeters G, Tusscher GT, Wallis M, Zuurbier M. Exposure to multiple environmental agents and their effect. Acta Paediatr Suppl 2006;95(453):106-113. (Pubitemid 44465424)
42. Wheldon TE, Mairs R, Barrett A. Germ cell injury and childhood leukemia clusters. Lancet 1989;1:792-793. (Pubitemid 19093524)
43. Evrard A-S, H́emon D, Morin A, Laurier D, Tirmarche M, Backe JC, Chartier M, Clavel J. Childhood leukemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates. Br J Cancer 2006;94(9):1342-1347.
44. Fairlie I. Uncertainties in doses and risks from internal radiation. Medicine, Conflict and Survival 2005;21(2):111-126.
45. Fairlie I. RBE and wR values of auger emitters and low-range beta emitters with particular reference to tritium. Journal of Radiological Protection 2007;27: 157-168. (Pubitemid 46830651)
46. Committee Examining the Radiation Risks of Internal Emitters (CERRIE). Report of the Committee Examining the Radiation Risks of Internal Emitters. Chilton, Oxon, UK: Health Protection Agency; 2004. Available at www.cerrie.org
47. Provincial Government of Ontario. Report of Ontario Select Committee on Hydro Matters. Toronto, Ontario, Canada: Provincial Government of Ontario; 1978. Available at http://www.ccnr.org/tritium 2.html#scoha
48. Stather JW, Phipps AW, Harrison JD, Eckerman KF, Smith TJ, Fell TP, Nosske D. Dose coefficients for the embryo and fetus following intakes of radionuclides by the mother. J Radiol Prot 2002;22:7-24 PII. (Pubitemid 34284763)
49. Health Protection Agency-Radiation Protection Division (HPA-RP). Guidance on the application of dose coefficients for the embryo, fetus and breastfed infant in dose assessments for members of the public (RCE-5). Chilton, Oxon, UK: HPA-RP; 2008.
50. Stewart A, Webb J, Giles D, Hewitt D. Malignant disease in childhood and diagnostic irradiation in utero. Lancet 1956;271:447-453.
51. Wakeford R. Childhood leukemia following medical diagnostic exposure to Ionising radiation in utero or after birth. Radiation Protection Dosimetry 2008;132(2): 166-174
52. Wakeford R, Little MP. Risk coefficients for childhood cancer after intrauterine irradiation: a review. Int J Radiat Biol 2003;79:293-309. (Pubitemid 36920531)
53. Monson RR, MacMahon B. Prenatal X-ray exposure and cancer in children. In: JD Boice Jr & JF Fraumeni JF Jr (Eds.). Radiation Carcinogenesis: Epidemiology and Biological Significance. New York: Raven Press; 1984:97-105.
54. Fucic A, Brunborg G, Lasan R, Jezek D, Knudsen LE, Merlo DF. Genomic damage in children accidentally exposed to ionizing radiation: a review of the literature. Mutat Res 2008;658(1-2):111-123
55. Wakeford R, Kendall GM, Little MP. The proportion of childhood leukaemia incidence in Great Britain that may be caused by natural background ionizing radiation. Leukemia 2009;23(4):770-776
56. Mobbs S, Watson S, Harrison J, Muirhead C, Bouffler S. An Introduction to the Estimation of Risks Arising from Exposure to Low Doses of Ionising Radiation 2009. Health Protection Agency. Report HPA-RPD-055.
57. Baverstock K. Childhood leukemias are caused by background radiation. New Scientist. January 9, 2003;4.
58. Gardner MJ, Snee MP, Hall AJ, Powell CA, Downes S, Terrell JD. Results of casecontrol study of leukemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ 1990;300:423-429. (Pubitemid 20069261)
59. Morris JA. Leukaemia and lymphoma among young people near Sellafield. BMJ 1990;300(6725):676-678.
60. Morris JA. A mutational theory of leukaemogenesis. J Clin Pathol 1989;42:337-340
61. Lord BI, Mason TM, Humphreys ER. Age-dependent uptake and retention of 239Pu: its relationship to hemopoietic damage. Radiation Protection Dosimetry 1992;41:163-167.
62. Ohtaki K, Kodama Y, Nakano M, Itoh M, Awa AA, Cologne J, Nakamura N. Human fetuses do not register chromosome damage inflicted by radiation exposure in lymphoid precursor cells except for a small but significant effect at low doses. Radiat Res 2004;161:373-379. (Pubitemid 40754233)