Na+-stimulated Na+/H+ exchange and an unfavorable Ca2+ homeostasis initiate the cycloxygenase-2 inhibitors-induced apoptotic signals in colonic epithelial cells during the early stage of colon carcinogenesis

Oncology Research

Volumn 18, Issue 5-6, 2009, Pages 243-257

  Kanwar, Shailender Singh ^a,c   Roy, Karnati R ^b,d   Nehru, Bimla ^a   Reddanna, Pallu ^b   Sanyal, Sankar Nath ^a  

^a PANJAB UNIVERSITY   (India)

^b UNIVERSITY OF HYDERABAD   (India)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Apoptosis; Ca2+ homeostasis; Colon carcinogenesis; Intracellular pH; Na+ H+ exchange

Indexed keywords

1,2 DIMETHYLHYDRAZINE; ACETYLSALICYLIC ACID; CALCIUM ION; CASPASE 3; CELECOXIB; CYCLOOXYGENASE 2; CYTOCHROME C; ETORICOXIB; FURA 2 ACETOXYMETHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; CALCIUM; CASPASE; CYCLOOXYGENASE 2 INHIBITOR; PTGS2 PROTEIN, RAT; PYRAZOLE DERIVATIVE; SODIUM; SODIUM PROTON EXCHANGE PROTEIN; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CANCER INHIBITION; CELL PH; COLON CARCINOGENESIS; COLON CARCINOMA; COLON MUCOSA; CONTROLLED STUDY; ENZYME INHIBITION; FLUORESCENCE MICROSCOPY; INTESTINE BRUSH BORDER MEMBRANE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COLON; COLON TUMOR; DRUG EFFECT; ENZYME ACTIVATION; EPITHELIUM CELL; HOMEOSTASIS; ION TRANSPORT; METABOLISM; PATHOLOGY; PH; SPRAGUE DAWLEY RAT;

1,2-DIMETHYLHYDRAZINE; ANIMALS; APOPTOSIS; CALCIUM; CASPASES; COLON; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYTOCHROMES C; ENZYME ACTIVATION; EPITHELIAL CELLS; HOMEOSTASIS; HYDROGEN-ION CONCENTRATION; ION TRANSPORT; MALE; POLY(ADP-RIBOSE) POLYMERASES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SODIUM-HYDROGEN ANTIPORTER; SULFONAMIDES;

EID: 77951213558     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504009X12596189659286     Document Type: Article

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