Sildenafil attenuates pulmonary arterial pressure but does not improve oxygenation during ARDS

Intensive Care Medicine

Volumn 36, Issue 5, 2010, Pages 758-764

  Cornet, Alexander D ^a   Hofstra, Jorrit J ^b   Swart, Eleonora L ^a   Girbes, Armand R J ^a   Juffermans, Nicole P ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

ARDS; Hypoxemia; ICU; Pulmonary hypertension; Sildenafil

Indexed keywords

OXYGEN; SILDENAFIL;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ARTERIAL OXYGEN SATURATION; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD GAS ANALYSIS; CENTRAL VENOUS PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; FEMALE; HEART INDEX; HEART OUTPUT; HEART RATE; HUMAN; INTENSIVE CARE UNIT; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN ARTERIAL PRESSURE; MULTICENTER STUDY; NASOGASTRIC TUBE; POSITIVE END EXPIRATORY PRESSURE; PULMONARY ARTERY OCCLUSION PRESSURE; PULMONARY HYPERTENSION; SINGLE DRUG DOSE; SYSTEMIC VASCULAR RESISTANCE; TREATMENT RESPONSE; UNIVERSITY HOSPITAL;

3',5'-CYCLIC-GMP PHOSPHODIESTERASES; ADULT; AGED; COHORT STUDIES; FEMALE; HUMANS; HYPERTENSION, PULMONARY; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; OXYGEN; OXYGEN CONSUMPTION; PIPERAZINES; PROSPECTIVE STUDIES; PULMONARY ARTERY; PURINES; RESPIRATORY DISTRESS SYNDROME, ADULT; SULFONES; VASODILATOR AGENTS;

EID: 77951208515     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-010-1754-3     Document Type: Article

References (38)

1. J Wind J Versteegt J Twisk TS van der Werf AJGH Bindels JJ Spijkstra ARJ Girbes ABJ Groeneveld 2007 Epidemiology of acute lung injury and acute respiratory distress syndrome in The Netherlands: a survey Respir Med 101 2091 2098 10.1016/j.rmed.2007.05.021 17616453 (Pubitemid 47324255)
2. LB Ware MA Matthay 2000 The acute respiratory distress syndrome N Engl J Med 342 1334 1349 10.1056/NEJM200005043421806 1:STN:280:DC%2BD3c3jvFGhsw%3D%3D 10793167 (Pubitemid 30408719)
3. ED Morrell BM Tsai PR Crisostomo ZT Hammoud DR Meldrum 2006 Experimental therapies for hypoxia-induced pulmonary hypertension during acute lung injury Shock 25 214 226 10.1097/01.shk.0000191380.44972.46 1:CAS:528: DC%2BD28Xis1antbk%3D 16552352
4. MJ Schultz JJ Haitsma H Zhang AS Slutsky 2006 Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia-a review Crit Care Med 34 871 877 16521285
5. V Kuklin M Kirov M Sovershaev T Andreasen OC Ingebretsen K Ytrehus L Bjertnaes 2005 Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C Crit Care 9 R211 R217 10.1186/cc3497 15987392
6. Y Ishitsuka H Moriuchi K Hatamoto C Yang J Takase S Golbidi M Irikura T Irie 2004 Involvement of thromboxane A2 (TXA2) in the early stages of oleic acid-induced lung injury and the preventive effect of ozagrel, a TXA2 synthase inhibitor, in guinea-pigs J Pharm Pharmacol 56 513 520 10.1211/0022357023150 1:CAS:528:DC%2BD2cXkt1eru7w%3D 15099446 (Pubitemid 38455617)
7. ED Moloney TW Evans 2003 Pathophysiology and pharmacological treatment of pulmonary hypertension in acute respiratory distress syndrome Eur Respir J 21 720 727 10.1183/09031936.03.00120102 1:CAS:528:DC%2BD3sXks1agsb0%3D 12762363
8. JDJ Roberts JR Fineman FC Morin PW Shaul S Rimar MD Schreiber RA Polin MS Zwass MM Zayek I Gross MA Heymann WM Zapol 1997 Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group N Engl J Med 336 605 610 10.1056/NEJM199702273360902 1:CAS:528: DyaK2sXhvVehsrc%3D 9032045 (Pubitemid 27093405)
9. LM Bigatello WE Hurford RM Kacmarek JDJ Roberts WM Zapol 1994 Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation Anesthesiology 80 761 770 10.1097/00000542-199404000-00007 1:STN:280: DyaK2c3psF2iug%3D%3D 8024129
10. R Rossaint KJ Falke F Lopez K Slama U Pison WM Zapol 1993 Inhaled nitric oxide for the adult respiratory distress syndrome N Engl J Med 328 399 405 10.1056/NEJM199302113280605 1:STN:280:DyaK3s7jtlagsA%3D%3D 8357359 (Pubitemid 23042288)
11. NK Adhikari KE Burns JO Friedrich JT Granton DJ Cook MO Meade 2007 Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis BMJ 334 779 10.1136/bmj.39139.716794.55 10.1136/bmj.39139.716794.55 17383982 (Pubitemid 46650121)
12. P Krafft P Fridrich RD Fitzgerald D Koc H Steltzer 1996 Effectiveness of nitric oxide inhalation in septic ARDS Chest 109 486 493 10.1378/chest.109.2.486 1:STN:280:DyaK287oslKktw%3D%3D 8620727
13. KF Rabe H Tenor G Dent C Schudt M Nakashima H Magnussen 1994 Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors Am J Physiol 266 L536 L543 1:CAS:528:DyaK2cXksFCnsLo%3D 7515580
14. MM Kurrek WM Zapol A Holzmann G Filippov M Winkler KD Bloch 1995 In vivo lipopolysaccharide pretreatment inhibits cGMP release from the isolated-perfused rat lung Am J Physiol 269 L618 L624 1:CAS:528:DyaK2MXpslOhtL8%3D 7491980
15. A Holzmann C Manktelow J Weimann KD Bloch WM Zapol 2001 Inhibition of lung phosphodiesterase improves responsiveness to inhaled nitric oxide in isolated-perfused lungs from rats challenged with endotoxin Intensive Care Med 27 251 257 10.1007/s001340000774 1:STN:280:DC%2BD3M7ovVOltg%3D%3D 11280644 (Pubitemid 32208997)
16. C Boer ABJ Groeneveld GJ Scheffer JJ de Lange N Westerhof P Sipkema 2005 Induced nitric oxide impairs relaxation but not contraction in endotoxin-exposed rat pulmonary arteries J Surg Res 127 197 202 10.1016/j.jss.2005.03.015 1:CAS:528:DC%2BD2MXntVGmur8%3D 15921694 (Pubitemid 41080634)
17. R Coimbra H Melbostad W Loomis RD Porcides P Wolf M Tobar DB Hoyt 2006 LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression J Trauma 60 115 125 10.1097/01.ta.0000200075.12489.74 1:CAS:528:DC%2BD28XitFOktrY%3D 16456445
18. BC Sheridan RC McIntyre DR Meldrum DA Fullerton 1997 Phosphodiesterase inhibition overcomes pulmonary vasomotor dysfunction in acute lung injury J Surg Res 71 145 149 10.1006/jsre.1997.5139 1:CAS:528:DyaK2sXmslOktbo%3D 9299282 (Pubitemid 27400955)
19. RE Howell LP Jenkins DE Howell 1995 Inhibition of lipopolysaccharide- induced pulmonary edema by isozyme-selective phosphodiesterase inhibitors in guinea pigs J Pharmacol Exp Ther 275 703 709 1:CAS:528:DyaK2MXpsF2hu78%3D 7473157
20. A Klein U Zils C Bopp A Gries E Martin R Gust 2007 Low-dose phosphodiesterase inhibition improves responsiveness to inhaled nitric oxide in isolated lungs from endotoxemic rats J Surg Res 138 224 230 10.1016/j.jss.2005. 12.010 1:CAS:528:DC%2BD2sXis1yitL8%3D 17275845 (Pubitemid 46365716)
21. HA Ghofrani F Reichenberger MG Kohstall EH Mrosek T Seeger H lschewski W Seeger F Grimminger 2004 Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial Ann Intern Med 141 169 177 1:CAS:528:DC%2BD2cXntVKjsLs%3D 15289213
22. N Galie HA Ghofrani A Torbicki RJ Barst LJ Rubin D Badesch T Fleming T Parpia G Burgess A Branzi F Grimminger M Kurzyna G Simonneau 2005 Sildenafil citrate therapy for pulmonary arterial hypertension N Engl J Med 353 2148 2157 10.1056/NEJMoa050010 1:CAS:528:DC%2BD2MXht1ajtb%2FI 16291984 (Pubitemid 41653106)
23. HA Ghofrani R Wiedemann F Rose RT Schermuly H Olschewski N Weissmann A Gunther D Walmrath W Seeger F Grimminger 2002 Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial Lancet 360 895 900 10.1016/S0140-6736(02)11024-5 1:CAS:528:DC%2BD38Xnt1Cqsrs%3D 12354470 (Pubitemid 35283832)
24. GR Bernard A Artigas KL Brigham J Carlet K Falke L Hudson M Lamy JR Legall A Morris R Spragg 1994 The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination Am J Respir Crit Care Med 149 818 824 1:STN:280: DyaK2c7mtlCnsA%3D%3D 7509706 (Pubitemid 24082248)
25. WA Knaus EA Draper DP Wagner JE Zimmerman 1985 APACHE II: a severity of disease classification system Crit Care Med 13 818 829 10.1097/00003246- 198510000-00009 1:STN:280:DyaL2M3otlyqtQ%3D%3D 3928249
26. RM Vos A Chahbouni A Sinjewel EL Swart 2008 Quantitative analysis of sildenafil and desmethylsildenafil in human serum by liquid chromatography-mass spectrometry with minimal sample pretreatment J Chromatogr B Analyt Technol Biomed Life Sci 876 283 287 10.1016/j.jchromb.2008.10.052 1:CAS:528: DC%2BD1cXhsVCntLfL 19026603
27. JJ Lepore A Maroo LM Bigatello GW Dec WM Zapol KD Bloch MJ Semigran 2005 Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide Chest 127 1647 1653 10.1378/chest.127.5.1647 1:CAS:528:DC%2BD2MXkvFyhsLg%3D 15888841 (Pubitemid 46218790)
28. O Pak A Aldashev D Welsh A Peacock 2007 The effects of hypoxia on the cells of the pulmonary vasculature Eur Respir J 30 364 372 10.1183/09031936. 00128706 1:CAS:528:DC%2BD2sXpvFCgs7c%3D 17666559 (Pubitemid 47201724)
29. LA Shimoda JS Sham JT Sylvester 2000 Altered pulmonary vasoreactivity in the chronically hypoxic lung Physiol Res 49 549 560 1:STN:280: DC%2BD3M7ltlCmuw%3D%3D 11191359
30. WM Zapol MT Snider 1977 Pulmonary hypertension in severe acute respiratory failure N Engl J Med 296 476 480 1:STN:280:DyaE2s7gtVaisQ%3D%3D 834225
31. A Vieillard-Baron JM Schmitt R Augarde JL Fellahi S Prin B Page A Beauchet F Jardin 2001 Acute cor pulmonale in acute respiratory distress syndrome submitted to protective ventilation: incidence, clinical implications and prognosis Crit Care Med 29 1551 1555 10.1097/00003246-200108000-00009 1:STN:280:DC%2BD3MvlvVygug%3D%3D 11505125
32. M Monchi F Bellenfant A Cariou LM Joly D Thebert I Laurent JF Dhainaut F Brunet 1998 Early predictive factors of survival in the acute respiratory distress syndrome. A multivariate analysis Am J Respir Crit Care Med 158 1076 1081 1:STN:280:DyaK1cvktlaqug%3D%3D 9769263
33. A Vieillard-Baron 2009 Is right ventricular function the one that matters in ARDS patients? Definitely yes Intensive Care Med 35 4 6 10.1007/s00134-008- 1308-0 18839136
34. A Mekontso Dessap C Charron J Devaquet J Aboab F Jardin L Brochard A Vieillard-Baron 2009 Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome Intensive Care Med 35 1850 1858 10.1007/s00134-009-1569-2 19652953
35. A Vieillard-Baron C Charron V Caille G Belliard B Page F Jardin 2007 Prone positioning unloads the right ventricle in severe ARDS Chest 132 1440 1446 10.1378/chest.07-1013 17925425 (Pubitemid 350155997)
36. JL Vincent H Zhang C Szabo JC Preiser 2000 Effects of nitric oxide in septic shock Am J Respir Crit Care Med 161 1781 1785 1:STN:280: DC%2BD3czhtFeqtA%3D%3D 10852744
37. RJM Strack van Schijndel NJ Wierdsma EMB van Heijningen PJM Weijs SDW de Groot ARJ Girbes 2006 Fecal energy losses in enterally fed intensive care patients: an explorative study using bomb calorimetry Clin Nutr 25 758 764 10.1016/j.clnu.2005.11.012 1:STN:280:DC%2BD28rnvVCisw%3D%3D 16698144 (Pubitemid 44426424)
38. F Scaglione L Paraboni 2008 Pharmacokinetics/pharmacodynamics of antibacterials in the intensive care unit: setting appropriate dosing regimens Int J Antimicrob Agents 32 294 301 10.1016/j.ijantimicag.2008.03.015 1:CAS:528:DC%2BD1cXhtVyjurvK 18621508