Nonimmunodominant Regions Are Effective as Building Blocks in a Streptococcal Fusion Protein Vaccine

Cell Host and Microbe

Volumn 2, Issue 6, 2007, Pages 427-434

  Stålhammar Carlemalm, Margaretha ^a   Waldemarsson, Johan ^a   Johnsson, Eskil ^a   Areschoug, Thomas ^a   Lindahl, Gunnar ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM ANTIBODY; HYBRID PROTEIN; IMMUNOLOGICAL ADJUVANT; MEMBRANE PROTEIN; OPSONIN; PROTEIN M22; PROTEIN RIB; STREPTOCOCCUS VACCINE; UNCLASSIFIED DRUG;

ACTIVE IMMUNIZATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG EFFICACY; EPITHELIUM CELL; IMMUNOMODULATION; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; PROTEIN TARGETING; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PYOGENES; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; ANTIGENS, SURFACE; BACTERIAL PROTEINS; EPITHELIAL CELLS; EPITOPES; IMMUNIZATION; ISCOMS; MEMBRANE PROTEINS; MICE; MICE, INBRED C3H; STREPTOCOCCAL INFECTIONS; STREPTOCOCCAL VACCINES; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS PYOGENES;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PYOGENES; STREPTOCOCCUS SP. 'GROUP B';

EID: 36749079247     PISSN: 19313128     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chom.2007.10.003     Document Type: Article

References (31)

1. Bolduc G.R., Baron M.J., Gravekamp C., Lachenauer C.S., and Madoff L.C. The alpha C protein mediates internalization of group B Streptococcus within human cervical epithelial cells. Cell. Microbiol. 4 (2002) 751-758
2. Brimil N., Barthell E., Heindrichs U., Kuhn M., Lutticken R., and Spellerberg B. Epidemiology of Streptococcus agalactiae colonization in Germany. Int. J. Med. Microbiol. 296 (2006) 39-44
3. Brochet M., Couve E., Zouine M., Vallaeys T., Rusniok C., Lamy M.C., Buchrieser C., Trieu-Cuot P., Kunst F., Poyart C., and Glaser P. Genomic diversity and evolution within the species Streptococcus agalactiae. Microbes Infect. 8 (2006) 1227-1243
4. Brodeur B.R., Boyer M., Charlebois I., Hamel J., Couture F., Rioux C.R., and Martin D. Identification of group B streptococcal Sip protein, which elicits cross-protective immunity. Infect. Immun. 68 (2000) 5610-5618
5. Buccato S., Maione D., Rinaudo C.D., Volpini G., Taddei A.R., Rosini R., Telford J.L., Grandi G., and Margarit I. Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal disease. J. Infect. Dis. 194 (2006) 331-340
6. Carlsson F., Berggård K., Stålhammar-Carlemalm M., and Lindahl G. Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein. J. Exp. Med. 198 (2003) 1057-1068
7. Denny Jr. F.W., Perry W.D., and Wannamaker L.W. Type-specific streptococcal antibody. J. Clin. Invest. 36 (1957) 1092-1100
8. Edwards M.S., and Baker C.J. Group B streptococcal infections. In: Remington S., and Klein J.O. (Eds). Infectious Disease of the Fetus and the Newborn Infant (2001), W.B. Saunders Company, Philadelphia 1091-1155
9. Fischetti V.A., and Windels M. Mapping the immunodeterminants of the complete streptococcal M6 protein molecule. J. Immunol. 141 (1988) 3592-3599
10. Gravekamp C., Horensky D.S., Michel J.L., and Madoff L.C. Variation in repeat number within the alpha C protein of group B streptococci alters antigenicity and protective epitopes. Infect. Immun. 64 (1996) 3576-3583
11. Gravekamp C., Kasper D.L., Michel J.L., Kling D.E., Carey V., and Madoff L.C. Immunogenicity and protective efficacy of the alpha C protein of group B streptococci are inversely related to the number of repeats. Infect. Immun. 65 (1997) 5216-5221
12. Holtappels R. Dominating immune response. Immunodominance and its significance in immunity. B.I.F. Futura 20 (2005) 157-163
13. Johnsson E., Areschoug T., Mestecky J., and Lindahl G. An IgA-binding peptide derived from a streptococcal surface protein. J. Biol. Chem. 274 (1999) 14521-14524
14. Kehoe M.A. Cell-wall-associated proteins in Gram-positive bacteria. N. Compr. Biochem. 27 (1994) 217-261
15. Kling D.E., Gravekamp C., Madoff L.C., and Michel J.L. Characterization of two distinct opsonic and protective epitopes within the alpha C protein of the group B Streptococcus. Infect. Immun. 65 (1997) 1462-1467
16. Kong F., Gowan S., Martin D., James G., and Gilbert G.L. Molecular profiles of group B streptococcal surface protein antigen genes: Relationship to molecular serotypes. J. Clin. Microbiol. 40 (2002) 620-626
17. Larsson C., Stålhammar-Carlemalm M., and Lindahl G. Experimental vaccination against group B streptococcus, an encapsulated bacterium, with highly purified preparations of cell surface proteins Rib and alpha. Infect. Immun. 64 (1996) 3518-3523
18. Larsson C., Stålhammar-Carlemalm M., and Lindahl G. Protection against experimental infection with group B streptococcus by immunization with a bivalent protein vaccine. Vaccine 17 (1999) 454-458
19. Larsson C., Lindroth M., Nordin P., Stålhammar-Carlemalm M., Lindahl G., and Krantz I. Association between low concentrations of antibodies to protein alpha and Rib and invasive neonatal group B streptococcal infection. Arch. Dis. Child. Fetal Neonatal Ed. 91 (2006) F403-F408
20. Lindahl G., Stålhammar-Carlemalm M., and Areschoug T. Surface proteins of Streptococcus agalactiae and related proteins in other bacterial pathogens. Clin. Microbiol. Rev. 18 (2005) 102-127
21. Maione D., Margarit I., Rinaudo C.D., Masignani V., Mora M., Scarselli M., Tettelin H., Brettoni C., Iacobini E.T., Rosini R., et al. Identification of a universal Group B streptococcus vaccine by multiple genome screen. Science 309 (2005) 148-150
22. Michel J.L., Madoff L.C., Olson K., Kling D.E., Kasper D.L., and Ausubel F.M. Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci. Proc. Natl. Acad. Sci. USA 89 (1992) 10060-10064
23. Morfeldt E., Berggård K., Persson J., Drakenberg T., Johnsson E., Lindahl E., Linse S., and Lindahl G. Isolated hypervariable regions derived from streptococcal M proteins specifically bind human C4b-binding protein: Implications for antigenic variation. J. Immunol. 167 (2001) 3870-3877
24. Nara P.L., and Garrity R. Deceptive imprinting: A cosmopolitan strategy for complicating vaccination. Vaccine 16 (1998) 1780-1787
25. Rappuoli R. Reverse vaccinology. Curr. Opin. Microbiol. 3 (2000) 445-450
26. Reddin K.M., Crowley-Luke A., Clark S.O., Vincent P.J., Gorringe A.R., Hudson M.J., and Robinson A. Bordetella pertussis fimbriae are effective carrier proteins in Neisseria meningitidis serogroup C conjugate vaccines. FEMS Immunol. Med. Microbiol. 31 (2001) 153-162
27. Rubens C.E., Raff H.V., Jackson J.C., Chi E.Y., Bielitzki J.T., and Hillier S.L. Pathophysiology and histopathology of group B streptococcal sepsis in Macaca nemestrina primates induced after intraamniotic inoculation: Evidence for bacterial cellular invasion. J. Infect. Dis. 164 (1991) 320-330
28. Serruto D., and Rappuoli R. Post-genomic vaccine development. FEBS Lett. 580 (2006) 2985-2992
29. Stenberg L., O'Toole P.W., Mestecky J., and Lindahl G. Molecular characterization of protein Sir, a streptococcal cell surface protein that binds both immunoglobulin A and immunoglobulin G. J. Biol. Chem. 269 (1994) 13458-13464
30. Stålhammar-Carlemalm M., Stenberg L., and Lindahl G. Protein Rib: A novel group B streptococcal cell surface protein that confers protective immunity and is expressed by most strains causing invasive infections. J. Exp. Med. 177 (1993) 1593-1603
31. Wästfelt M., Stålhammar-Carlemalm M., Delisse A.M., Cabezon T., and Lindahl G. Identification of a family of streptococcal surface proteins with extremely repetitive structure. J. Biol. Chem. 271 (1996) 18892-18897