Effect of administration of aqueous extract of hippobromus pauciflorus leaves in male wistar rats

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 7, Issue 1, 2010, Pages 40-46

  Pendota, S C ^a   Yakubu, M T ^a   Grierson, D S ^a   Afolayan, A J ^a  

^a UNIVERSITY OF FORT HARE   (South Africa)

Author keywords

Haematotoxic; Hepatotoxic; Hippobromus pauciflorus; Nephrotoxic; Oral remedy

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN GLUCURONIDE; CHOLESTEROL; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLOBULIN; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HIPPOBROMUS PAUCIFLORUS EXTRACT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHATE; PLANT EXTRACT; POTASSIUM; UNCLASSIFIED DRUG; UREA; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASOPHIL; BILIRUBIN BLOOD LEVEL; BLOOD TOXICITY; BODY WEIGHT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; DRUG SAFETY; ENZYME ACTIVITY; EOSINOPHIL COUNT; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HIPPOBROMUS PAUCIFLORUS; KIDNEY MASS; LEUKOCYTE COUNT; LIVER TOXICITY; LIVER WEIGHT; LYMPHOCYTE COUNT; MALE; MALE ANIMAL; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; MONOCYTE; NEPHROTOXICITY; NEUTROPHIL COUNT; NONHUMAN; PHOSPHATE BLOOD LEVEL; PLANT LEAF; POTASSIUM BLOOD LEVEL; RAT; SAPINDACEAE; THROMBOCYTE COUNT; TOXICITY TESTING; TREATMENT DURATION; UREA BLOOD LEVEL; WISTAR RAT;

ANIMALS; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; KIDNEY; LIVER; MALE; ORGAN SIZE; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; SAPINDACEAE; WATER;

EID: 77951191433     PISSN: 01896016     EISSN: 01896016     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Adebayo, J. O., Adesokan, A. A., Olatunji, L. A., Buoro, D. O. and Soladoye, A. O. (2005). Effect of ethanolic extract of Bougainvillea spectabilis leaves on haematological and serum lipid variables in rats. Biokemistri, 17: 45-50.
2. Amresh, G. R., Singh, P. N. and Rao C. V. (2008). Toxicological screening of traditional medicine Laghupatha (Cissampelos pareira) in experimental animals. J. Ethnopharmacol., 116: 454-460.
3. Clarkson, C., Vinesh, J. M., Neil, R. C., Olwen, M. G., Pamisha, P., Motlalepula, G. M., Niresh, B., Peter, J. S. and Peter, I. F. (2004). In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa. J. Ethnopharmacol., 92: 177-191.
4. Isnard, B. C., Deray, G., Baumelou, A., Le Quintree, M. and Vanherweghem, J. L. (2004). Herbs and the kidney. Am. J. Kidney Dis. 44: 1-11.
5. Jesse, B. (1982). Animal Anatomy and Physiology. Reston Publishing Company. Inc., Reston, USA., pp. 521.
6. Leonardo, D. C. L., Franco, A., Gustavo, A. T. L., Luciano, M. A., Lius, F. M. E. S., Gabriele, P. D. S., Isabela, D. M. A., Jose, F. N. N., Israel, F. and Karla, K. (2000). Toxicological evaluation by in vitro and in vivo assays of an aqueous extract prepared from Echinodorus macrophyllus leaves. Toxicol. Letts., 116: 189-198.
7. Masika, P. J. and Afolayan, A. J. (2003). An ethnobotanical study of plants used for the treatment of livestock diseases in the Eastern Cape Province, South Africa. Pharm. Biol., 41: 16-21.
8. Moudgil, K. D. and Narang, B. S. (1989). The liver and the Biliary System. In: Textbook of Biochemistry and Human Biology, 2nd Edn., Talwar, G.P., L.M. Srivastava and K.D. Moudgil (Eds.). Prentice-Hall of India Limited, New Delhi, India; pp. 271-273.
9. Nakanishi, M. and Goto, K. (1975). Inhibitory effect of anti-inflammatory drugs on enzyme release from rabbit polymorphonucleus leukocytes lysosomes. Biochem. Pharmacol., 24: 421-424.
10. Pendota, S. C., Grierson, D. S. and Afolayan, A. J. (2008). An ethanobotanical study of plants used for the treatment of eye infections in the Eastern Cape Province, South Africa. Pakistan J. Biol. Sci., 11: 2051-2053.
11. Rasekh, H. R., Nazari, P., Kamil-Nejad, N. and Hosseinzaden, L. (2008). Acute and subchronic toxicity of Galega officinalis in rats. J. Ethnopharmacol., 116: 21-26.
12. Reichling, J. J. and Kaplan, M. M. (1988). Clinical use of serum enzymes in liver disease. Digestive Dis. Sci., 33: 1601-1614.
13. Saad, B., Azaizeh, H., Abu-Hijleh, G., Said, S. (2006). Safety of traditional Arab herbal medicine. Evidence-Based Compl. & Altern. Med., 3: 433-439.
14. Tietz, N., Prude, W. E. L. and Sirgard-Anderson, O. (1994). In: Tietz Textbook of Clinical Chemistry. Burtis C. A. and Ashwood, E. R.(eds). W. B. Saunders Company, London, pp. 1354-1374.
15. Woodman, D. D. (1996). Assessment of hepatotoxicity. In: Evans, G.O. (ed.), Animal Clinical Chemistry, A Primer for Toxicologists. Taylor & Francis, London, pp. 71-86.
16. Wurochekke, A.U., Anthony, A.E. and Obidah, W. (2008). Biochemical effects on the liver and kidney of rats administered aqueous stem bark extract of Xemenia Americana. Afr. J. Biotechnol., 7: 2777-2780.
17. Yakubu, M. T., Akanji, M. A. and Oladiji, A. T. (2005). Aphrodisiac potentials of aqueous extract of Fadogia agrestis (Schweinf. Ex Heim) stem in male albino rats. Asian J. Androl., 7: 399-404.
18. Yakubu, M. T., Akanji, M. A. and Oladiji, A. T. (2007). Haematological evaluation in male albino rats following chronic administration of aqueous extract of Fadogia agrestis stem. Pharmacog. Mag., 3: 34-38.
19. Yakubu, M. T., Akanji, M. A. and Oladiji, A. T. (2008). Alterations in serum lipid profile of male rats by oral administration of aqueous extract of Fadogia agrestis stem. Res. J. Med.l Plant, 2: 66-73.