Acute and subchronic oral toxicity of Galega officinalis in rats

Journal of Ethnopharmacology

Volumn 116, Issue 1, 2008, Pages 21-26

  Rasekh, Hamid R ^a   Nazari, Pardis ^a   Kamli Nejad, Mohammad ^a   Hosseinzadeh, Leila ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute toxicity; Galega officinalis; Subchronic toxicity

Indexed keywords

ALBUMIN; BILIRUBIN; CHOLESTEROL; CREATINE KINASE; GALEGA OFFICINALIS EXTRACT; GLOBULIN; LACTATE DEHYDROGENASE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FLUID INTAKE; FOOD INTAKE; GALEGA OFFICINALIS; LD 50; LEUKOCYTE COUNT; LIVER CONGESTION; LUNG HEMORRHAGE; MALE; NONHUMAN; PLANT; RAT; THROMBOCYTE COUNT;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GALEGA; LIVER; LUNG; MALE; ORGAN SIZE; RATS;

ANIMALIA; GALEGA OFFICINALIS; PAPILIONOIDEAE; RATTUS; RATTUS NORVEGICUS;

EID: 38649087069     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.10.030     Document Type: Article

References (20)

1. Angelis Pereira M.C., Carvalho J.C.T., Lima L.M., Caputo L.R.G., Ferreira L.R., Fiorini J.E., and Bastos J.K. Toxicity of a subchronic treatment with hydroalcoholic crude extract from Solanum grandiflorum (Ruiz et Pav) in rats. Journal of Ethnopharmacology 89 (2003) 97-99
2. Atanasov A.T. Effect of the water extract of Galega officinalis L. on human platelet aggregation in vitro. Phytotherapy Research 8 (1994) 314-316
3. Atanasov A.T., and Spasov V. inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. Journal of Ethnopharmacology 69 (2000) 235-240
4. Atanasov A.T., and Tchorbanov B. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. Journal of Herbs, Spices and Medicinal Plants 10 (2002) 63-71
5. Bidhe R.M., and Ghosh S. Acute and subchronic (28-day) oral toxicity study in rats fed with novel surfactants. AAPS Pharmaceutical Sciences (2004) (6, Article 14)
6. Keeler R.F., Johnson A.E., Stuart L.D., and Evans J.O. Toxicosis from and possible adaptation to Galega officinalis in sheep and the relationship to Verbesina encelioides toxicosis. Veterinary and Human Toxicology 28 (1986) 309-315
7. Keeler R.F., Baker D.C., and Evans J.O. Individual animal susceptibility and its relationship to induce adaptation or tolerance in sheep to Galega officinalis. Veterinary and Human Toxicology 30 (1988) 420-423
8. Keeler R.F., Baker D.C., and Panter K.E. Concentration of galegine in Verbesina encelioides and Galega officinalis and the toxic and pathologic effects induced by the plants. Journal of Environmental Pathology, Toxicology and Oncology 11 (1992) 11-17
9. Keyler D.E., Baker J.I., Lee D.Y.W., Overstreet D.H., Boucher T.A., and Lenz S.K. Toxicity study of an antidipsotropic chinese herbal mixture in rats: NPI-028. The Journal of Alternative and Complementary Medicine 8 (2002) 175-183
10. Leporatti M.L., and Ivancheva S. Preliminary comparative analysis of medicinal plants used in the traditional medicine of Bulgaria and Italy. Journal of Ethnopharmacology 87 (2003) 123-142
11. Lopez T.A., Campero C.M., Chayer R., Cosentino B., and Caracino M. Experimental toxicity of Verbesina encelioides in sheep and isolation of galegine. Veterinary and Human Toxicology 38 (1996) 417-419
12. Oubre A.Y., Carlson T.J., King S.R., and Reaven G.M. From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia 40 (1997) 614-617
13. Palit P., Furman B.L., and Gray A.I. Novel weight-reducing activity of Galega officinalis in mice. The Journal of Pharmacy and Pharmacology 51 (1999) 1313-1319
14. Pundarikakshudu K., Patel J.K., Bodar M.S., and Deans S.G. Anti-bacterial activity of Galega officinalis L. (Goat's Rue). Journal of Ethnopharmacology 77 (2001) 111-112
15. Puyt J.D., Faliu L., Keck G., Gedfrain J.C., Pinault L., and Tainturier D. Fatal poisoning of sheep by Galega officinalis (French honeysuckle). Veterinary and Human Toxicology 23 (1981) 410-412
16. Uncini Manganelli R.E., Camangi F., and Tomei P.E. Curing animals with plants: traditional usage in Tuscany (Italy). Journal of Ethnopharmacology 78 (2001) 171-191
17. Vuksan V., and Sievenpiper J.L. Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutrition, Metabolism and Cardiovascular Diseases 15 (2005) 149-160
18. Wilson N.H., Hardisty J.F., and Hayes J.R. Short-term, subchronic, and chronic toxicology studies. In: Hayes A.W. (Ed). Principles and Methods of Toxicology (2001), Taylor & Francis, Philadelphia 917-956
19. Woodman D.D. Assessment of hepatotoxicity. In: Evans G.O. (Ed). Animal Clinical Chemistry, A Primer for Toxicologists (1996), Taylor & Francis, London 71-86
20. Yamakoshi J., Saito M., Kataoka S., and Kikuchi M. Safety evaluation of proanthocyanidin rich extract from grape seeds. Food and Chemical Toxicology 40 (2002) 599-607