Renoprotective effects of mineralocorticoid receptor blockade in heminephrectomized (pro)renin receptor transgenic rats

Clinical and Experimental Pharmacology and Physiology

Volumn 37, Issue 5-6, 2010, Pages 569-573

  Mizuguchi, Yuki ^a   Ichihara, Atsuhiro ^a   Seki, Yasufumi ^a   Sakoda, Mariyo ^a   Kurauchi Mito, Asako ^a   Narita, Tatsuya ^a   Kinouchi, Kenichiro ^a   Bokuda, Kanako ^a   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

(pro)renin receptor; Aldosterone; Dietary salt; Eplerenone; Heminephrectomy; Proteinuria; Slit diaphragm proteins

Indexed keywords

ALDOSTERONE; EPLERENONE; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; NEPHRIN; PODOCIN; PRORENIN RECEPTOR; PROTEIN ZO1; SLIT PROTEIN; CELL SURFACE RECEPTOR; MINERALOCORTICOID ANTAGONIST; SALT INTAKE; SPIRONOLACTONE;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION REGULATION; HEMINEPHRECTOMY; HIGH SODIUM INTAKE; KIDNEY DISEASE; KIDNEY STRUCTURE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; PROTEINURIA; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BLOCKING; RENAL PROTECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SODIUM BALANCE; SODIUM RESTRICTION; SPECIES DIFFERENCE; TRANSGENIC RAT; UPREGULATION; WILD TYPE; ADMINISTRATION AND DOSAGE; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; GENETICS; HUMAN; KIDNEY DISEASES; METABOLISM; NEPHRECTOMY; PHYSIOLOGY; SALT INTAKE;

ALDOSTERONE; ANIMALS; HUMANS; KIDNEY DISEASES; MINERALOCORTICOID RECEPTOR ANTAGONISTS; NEPHRECTOMY; RATS; RATS, TRANSGENIC; RECEPTORS, CELL SURFACE; SODIUM CHLORIDE, DIETARY; SPIRONOLACTONE;

EID: 77951111806     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2010.05360.x     Document Type: Article

References (20)

1. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer J-D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J. Clin. Invest. 2002 109 : 1417 1427.
2. Ichihara A, Hayashi M, Kaneshiro Y et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the 'handle' region for non-proteolytic activation of prorenin. J. Clin. Invest. 2004 114 : 1128 1135.
3. Kaneshiro Y, Ichihara A, Sakoda M et al. Slowly progressive, angiotensin II-independent glomerulosclerosis in human-renin/prorenin-receptor-transgenic rats. J. Am. Soc. Nephrol. 2007 18 : 1789 1795.
4. Burckle CA, Jan Danser AH, Muller DN et al. Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension 2006 47 : 552 556.
5. Bianchi S, Bigazzi R, Campese VM. Antagonist of aldosterone and proteinuria in patients with CKD. A controlled pilot study. Am. J. Kidney Dis. 2005 46 : 45 51.
6. Quinkler M, Zehnder D, Eardley KS et al. Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria. Circulation 2005 112 : 1435 1443.
7. Kaneshiro Y, Ichihara A, Takemitsu T et al. Increased expression of cyclooxygenase-2 in renal cortex of human-prorenin-receptor-gene transgenic rats. Kidney Int. 2006 70 : 641 646.
8. El-Nahas AM, Bassett AH, Cope GH, Carpentier JE. Role of growth hormone in the development of experimental renal scarring. Kidney Int. 1991 40 : 29 34.
9. Nagase M, Matsui H, Shibata S, Gotoda T, Fujita T. Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: Role of oxidative stress. Hypertension 2007 50 : 877 883.
10. Bianchi S, Bigazzi R, Campese VM. Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease. Kidney Int. 2006 70 : 2116 2123.
11. Nagase M, Shibata S, Yoshida S, Nagase T, Gotoda T, Fujita T. Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension 2006 47 : 1084 1093.
12. Shibata S, Nagase M, Yoshida S, Kawachi H, Fujita T. Podocyte as the target for aldosterone. Roles of oxidative stress and Sgk1. Hypertension 2007 49 : 355 364.
13. Fukasawa H, Bornheimer S, Kudlicka K, Farquhar MG. Slit diaphragms contain tight juction proteins. J. Am. Soc. Nephrol. 2009 20 : 1491 1503.
14. Siragy HM, Huang J. Renal (pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity. Exp. Physiol. 2008 93 : 709 714.
15. Ichihara A, Kaneshiro Y, Takemitsu T et al. Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage. J. Am. Soc. Nephrol. 2006 17 : 2495 2503.
16. Krebs C, Hamming I, Sadaghiani S et al. Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats. Kidney Int. 2007 72 : 725 730.
17. Guo C, Martinez-Vasquez D, Mendez GP et al. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of Type 1 and 2 diabetes mellitus. Endocrinology 2006 147 : 5363 5373.
18. de-Ias-Heras N, Ruiz-Ortega M, Miana M et al. Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats. J. Hypertens. 2007 25 : 629 638. (Pubitemid 46213802)
19. Ludwig J, Kerscher S, Brandt U et al. Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules. J. Biol. Chem. 1998 273 : 10. 939-47.
20. Paroutis P, Touret N, Grinstein S. The pH of the secretory pathway: Measurement, determinants and regulation. Physiology 2004 19 : 207 215.