EGFR (HER) family protein expression and cytogenetics in 219 squamous cell Carcinomas of the upper respiratory tract: ERBB2 overexpression independent prediction of poor prognosis

Analytical and Quantitative Cytology and Histology

Volumn 32, Issue 2, 2010, Pages 78-89

  Brunner, Kathrin ^a   Fischer, Claude A ^c   Driemel, Oliver ^b   Hartmann, Arndt ^a   Brockhoff, Gero ^b   Schwarz, Stephan ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

EGFR (HER1); ERBB2 (HER2); ERBB3 (HER3); ERBB4 (HER4); Squamous cell carcinoma

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; KI 67 ANTIGEN;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH; UPPER RESPIRATORY TRACT;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CHROMOSOME ABERRATIONS; DNA, NEOPLASM; FEMALE; HUMANS; HYPOPHARYNGEAL NEOPLASMS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; OROPHARYNGEAL NEOPLASMS; PROGNOSIS; RECEPTOR, ERBB-2; RETROSPECTIVE STUDIES; SURVIVAL RATE; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 77951101889     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Cancer incidence, mortality and prevalence worldwide. In International Agency for Research on Cancer-World Health Organization, GLOBOCAN, 2002. Available at: http:// www-dep.iarc.fr. Accessed December 15, 2008
2. Chang SS, Califano J: Current status of biomarkers in head and neck cancer. J Surg Oncol 2008;97:640-643 (Pubitemid 351812962)
3. Pignataro L, Pagani D, Brando B, Sambataro G, Scarpati B, Corsi MM: Down-regulation of zeta chain and zeta-associated protein 70 (Zap 70) expression in circulating T lymphocytes in laryngeal squamous cell carcinoma. Anal Quant Cytol Histol 2007;29:57-62 (Pubitemid 46333522)
4. Smilek P, Dusek L, Vesely K, Rottenberg J, Kostrica R: Correlation of expression of Ki-67, EGFR, c-erbB-2, MMP-9, p53, bcl-2, CD34 and cell cycle analysis with survival in head and neck squamous cell cancer. J Exp Clin Cancer Res 2006;25:549-555
5. Looi ML, Dali AZ, Ali SA, Ngah WZ, Yusof YA: Expression of p53, bcl-2 and Ki-67 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. Anal Quant Cytol Histol 2008;30:63-70
6. Rubio Bueno P, Naval Gias L, Garcia Delgado R, Domingo Cebollada J, Diaz Gonzalez FJ: Tumor DNA content as a prognostic indicator in squamous cell carcinoma of the oral cavity and tongue base. Head Neck 1998;20:232-239
7. Oya R, Ikemura K: Can flow cytometrically determined DNA ploidy and S-phase fraction predict regional metastasis in squamous cell carcinoma of the oral cavity? Head Neck 2002;24:136-142
8. Huang T, Chen M, Wu M, Wu X: Image analysis of DNA content and nuclear morphometry for predicting radiosensitivity of nasopharyngeal carcinoma. Anal Quant Cytol Histol 2008;30:169-174 (Pubitemid 351822240)
9. Gedoz L, Lauxen Ida S, Sant'Ana MF, Rados PV: Proliferative activity in clinically healthy oral mucosa exposed to tobacco smoking and alcohol: A longitudinal study using the agNOR staining technique. Anal Quant Cytol Histol 2007;29:231-238 (Pubitemid 47311331)
10. Campos Fontes P, Marques Correa GH, Scholz Issa J, Almeida JD: Quantitative analysis of AgNOR proteins in exfoliative cytology specimens of oral mucosa from smokers and nonsmokers. Anal Quant Cytol Histol 2008;30:16-24 (Pubitemid 351312096)
11. Kadivar M, Attar M: Argyrophilic nucleolar organizer region counts in exfoliative cytology of buccal mucosa from opium addicts, smokers and nonsmokers. Anal Quant Cytol Histol 2008;30:274-278
12. Silva SD, Agostini M, Nishimoto IN, Coletta RD, Alves FA, Lopes MA, Kowalski LP, Graner E: Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma: A clinicopathological study. Oral Oncol 2004;40:688-696
13. Xia W, Lau YK, Zhang HZ, Liu AR, Li L, Kiyokawa N, Clayman GL, Katz RL, Hung MC: Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma. Clin Cancer Res 1997;3:3-9 (Pubitemid 27079437)
14. Cavalot A, Martone T, Roggero N, Brondino G, Pagano M, Cortesina G: Prognostic impact of HER-2/neu expression on squamous head and neck carcinomas. Head Neck 2007;29:655-664 (Pubitemid 47168236)
15. O-charoenrat P, Rhys-Evans PH, Archer DJ, Eccles SA: CerbB receptors in squamous cell carcinomas of the head and neck: Clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factors. Oral Oncol 2002;38:73-80 (Pubitemid 34076575)
16. Khademi B, Shirazi FM, Vasei M, Doroudchi M, Gandomi B, Modjtahedi H, Pezeshki AM, Ghaderi A: The expression of p53, c-erbB-1 and c-erbB-2 molecules and their correlation with prognostic markers in patients with head and neck tumors. Cancer Lett 2002;184:223-230 (Pubitemid 34804508)
17. Fischer C, Zlobec I, Stockli E, Probst S, Storck C, Tornillo L, Lugli A, Wolfensberger M, Terracciano L: Is immunohistochemical epidermal growth factor receptor expression over-estimated as a prognostic factor in head-neck squamous cell carcinoma? A retrospective analysis based on a tissue mi croarray of 365 carcinomas. Hum Pathol 2008;39:1527-1534
18. Schartinger VH, Kacani L, Andrle J, Schwentner I, Wurm M, Obrist P, Oberaigner W, Sprinzl GM: Pharmacodiagnostic value of the HER family in head and neck squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec 2004;66:21-26 (Pubitemid 38586130)
19. Schlessinger J: Cell signaling by receptor tyrosine kinases. Cell 2000;103:211-225
20. Xia W, Lau YK, Zhang HZ, Xiao FY, Johnston DA, Liu AR, Li L, Katz RL, Hung MC: Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clin Cancer Res 1999;5:4164-4174
21. Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, Jarrett C, Carter J, Murphy BA, Netterville J, Burkey BB, Sinard R, Cmelak A, Levy S, Yarbrough WG, Slebos RJ, Hirsch FR: Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol 2006;24:4170-4176 (Pubitemid 46622295)
22. Khan AJ, King BL, Smith BD, Smith GL, DiGiovanna MP, Carter D, Haffty BG: Characterization of the HER-2/neu oncogene by immunohistochemical and fluorescence in situ hybridization analysis in oral and oropharyngeal squamous cell carcinoma. Clin Cancer Res 2002;8:540-548 (Pubitemid 34193975)
23. Sauter G, Simon R, Hillan K: Tissue microarrays in drug discovery. Nat Rev Drug Discov 2003;2:962-972
24. Chadwick B, Willmore-Payne C, Holden J, Layfield L: Fluorescence in situ hybridization determination of aneusomy: Criteria and technical considerations. Anal Quant Cytol Histol 2007;29:351-357 (Pubitemid 350304992)
25. Hirsch FR, Varella-Garcia M, McCoy J, West H, Xavier AC, Gumerlock P, Bunn PA Jr, Franklin WA, Crowley J, Gandara DR: Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group study. J Clin Oncol 2005;23:6838-6845 (Pubitemid 46260270)
26. Cappuzzo F, Hirsch FR, Rossi E, Bartolini S, Ceresoli GL, Bemis L, Haney J, Witta S, Danenberg K, Domenichini I, Ludovini V, Magrini E, Gregorc V, Doglioni C, Sidoni A, Tonato M, Franklin WA, Crino L, Bunn PA Jr, Varella-Garcia M: Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 2005;97:643-655 (Pubitemid 40812628)
27. Cappuzzo F, Varella-Garcia M, Shigematsu H, Domenichini I, Bartolini S, Ceresoli GL, Rossi E, Ludovini V, Gregorc V, Toschi L, Franklin WA, Crino L, Gazdar AF, Bunn PA Jr, Hirsch FR: Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients. J Clin Oncol 2005;23:5007-5018
28. Sassen A, Rochon J, Wild P, Hartmann A, Hofstaedter F, Schwarz S, Brockhoff G: Cytogenetic analysis of HER1/ EGFR, HER2, HER3 and HER4 in 278 breast cancer patients. Breast Cancer Res 2008;10:R2
29. Chin D, Boyle GM, Williams RM, Ferguson K, Pandeya N, Pedley J, Campbell CM, Theile DR, Parsons PG, Coman WB: Novel markers for poor prognosis in head and neck cancer. Int J Cancer 2005;113:789-797 (Pubitemid 40101261)
30. Hitt R, Ciruelos E, Amador ML, Benito A, Sanchez JJ, Ballestin C, Cortes-Funes H: Prognostic value of the epidermal growth factor receptor (EGRF) and p53 in advanced head and neck squamous cell carcinoma patients treated with induction chemotherapy. Eur J Cancer 2005;41:453-460 (Pubitemid 40187218)
31. Hass HG, Schmidt A, Nehls O, Kaiser S: DNA ploidy, proliferative capacity and intratumoral heterogeneity in primary and recurrent head and neck squamous cell carcinomas (HNSCC): Potential implications for clinical management and treatment decisions. Oral Oncol 2008;44:78-85 (Pubitemid 350251283)
32. Charuruks N, Shin DM, Voravud N, Ro JY, Hong WK, Hittelman WN: P53 expression and polysomies of chromosome 9, 17 in head and neck cancer prognosis. Chotmaihet Thangphaet 1999;82:466-476