Real-time monitoring of membrane cholesterol reveals new insights into epidermal differentiation

Journal of Investigative Dermatology

Volumn 130, Issue 5, 2010, Pages 1268-1278

  Spörl, Florian ^a   Wunderskirchner, Minetta ^a   Ullrich, Oliver ^b   Bömke, Gerrit ^a   Breitenbach, Ute ^a   Blatt, Thomas ^a   Wenck, Horst ^a   Wittern, Klaus Peter ^a   Schrader, Annika ^a  

^a BEIERSDORF AG   (Germany)

^b HAMBURG UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHOLESTEROL; CYTOKERATIN 1; CYTOKERATIN 10; CYTOKERATIN 2; MESSENGER RNA; METHYL BETA CYCLODEXTRIN;

ARTICLE; CELL DIFFERENTIATION; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EPIDERMIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; KERATINOCYTE; LIPID RAFT; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; THIN LAYER CHROMATOGRAPHY;

EID: 77951093917     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.412     Document Type: Article

References (35)

1. Ahn KW, Sampson NS (2004) Cholesterol oxidase senses subtle changes in lipid bilayer structure. Biochemistry 43:827-836
2. Bang B, Gniadecki R, Gajkowska B (2005) Disruption of lipid rafts causes apoptotic cell death in HaCaT keratinocytes. Exp Dermatol 14:266-272
3. Benton JM, Brown PE, Church RE (1963) The serum-cholesterol in psoriasis. Lancet 1:583-584
4. Bikle DD (2004) Vitamin D regulated keratinocyte differentiation. J Cell Biochem 92:436-444
5. Bloor BK, Tidman N, Leigh IM et al. (2003) Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization. Am J Pathol 162:963-975
6. Castanho MA, Prieto MJ (1992) Fluorescence study of the macrolide pentaene antibiotic filipin in aqueous solution and in a model system of membranes. Eur J Biochem 207:125-134
7. Collin C, Moll R, Kubicka S et al. (1992) Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation. Exp Cell Res 202:132-141
8. Dunham WR, Klein SB, Rhodes LM et al. (1996) Oleic acid and linoleic acid are the major determinants of changes in keratinocyte plasma membrane viscosity. J Invest Dermatol 107:332-335
9. Fra AM, Williamson E, Simons K et al. (1994) Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae. J Biol Chem 269:30745-30748
10. Fuchs E (1990) Epidermal differentiation: the bare essentials. J Cell Biol 111:2807-2814
11. Fuchs E, Raghavan S (2002) Getting under the skin of epidermal morphogenesis. Nat Rev Genet 3:199-209
12. Gimpl G, Gehrig-Burger K (2007) Cholesterol reporter molecules. Biosci Rep 27:335-358
13. Gniadecki R, Bang B (2003) Flotillas of lipid rafts in transit amplifying cell-like keratinocytes. J Invest Dermatol 121:522-528
14. Gniadecki R, Christoffersen N, Wulf HC (2002) Cholesterol-rich plasma membrane domains (lipid rafts) in keratinocytes: importance in the baseline and UVA-induced generation of reactive oxygen species. J Invest Dermatol 118:582-588
15. Hennings H, Holbrook KA (1983) Calcium regulation of cell-cell contact and differentiation of epidermal cells in culture. An ultrastructural study. Exp Cell Res 143:127-142
16. Hennings H, Michael D, Cheng C et al. (1980) Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19:245-254 (Pubitemid 10154229)
17. Jamora C, Fuchs E (2002) Intercellular adhesion, signalling and the cytoskeleton. Nat Cell Biol 4:E101-8
18. Jans R, Atanasova G, Jadot M et al. (2004) Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38. J Invest Dermatol 123:564-573
19. Jensen UB, Lowell S, Watt FM (1999) The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis. Development 126:2409-2418
20. Jones PH, Harper S, Watt FM (1995) Stem cell patterning and fate in human epidermis. Cell 80:83-93
21. Kita T, Brown MS, Goldstein JL (1980) Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. J Clin Invest 66:1094-1100
22. Klein U, Gimpl G, Fahrenholz F (1995) Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor. Biochemistry 34:13784-13793
23. Kolly C, Suter MM, Muller EJ (2005) Proliferation, cell cycle exit, and onset of terminal differentiation in cultured keratinocytes: pre-programmed pathways in control of C-Myc and Notch1 prevail over extracellular calcium signals. J Invest Dermatol 124:1014-1025
24. Kremer H, Zeeuwen P, McLean WH et al. (1994) Ichthyosis bullosa of Siemens is caused by mutations in the keratin 2e gene. J Invest Dermatol 103:286-289
25. Lambert S, Vind-Kezunovic D, Karvinen S et al. (2006) Ligand-independent activation of the EGFR by lipid raft disruption. J Invest Dermatol 126:954-962
26. Lincoln JE, Boling M, Parikh AN et al. (2006) Fas signaling induces raft coalescence that is blocked by cholesterol depletion in human RPE cells undergoing apoptosis. Invest Ophthalmol Vis Sci 47:2172-2178
27. McLean WH, Morley SM, Lane EB et al. (1994) Ichthyosis bullosa of Siemens-a disease involving keratin 2e. J Invest Dermatol 103:277-281
28. Menon GK, Feingold KR, Mao-Qiang M et al. (1992) Structural basis for the barrier abnormality following inhibition of HMG CoA reductase in murine epidermis. J Invest Dermatol 98:209-219
29. Meyle J, Gultig K, Rascher G et al. (1999) Transepithelial electrical resistance and tight junctions of human gingival keratinocytes. J Periodontal Res 34:214-222
30. Ponec M, Havekes L, Kempenaar J et al. (1985) Calcium-mediated regulation of the low density lipoprotein receptor and intracellular cholesterol synthesis in human epidermal keratinocytes. J Cell Physiol 125:98-106
31. Potten CS (1981) Cell replacement in epidermis (keratopoiesis) via discrete units of proliferation. Int Rev Cytol 69:271-318
32. Schmidt R, Parish EJ, Dionisius V et al. (1991) Modulation of cellular cholesterol and its effect on cornified envelope formation in cultured human epidermal keratinocytes. J Invest Dermatol 97:771-775
33. Simons K, Ikonen E (1997) Functional rafts in cell membranes. Nature 387:569-572
34. Simons K, Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31-39
35. Yancey PG, Rodrigueza WV, Kilsdonk EP et al. (1996) Cellular cholesterol efflux mediated by cyclodextrins. Demonstration of kinetic pools and mechanism of efflux. J Biol Chem 271:16026-16034