Cathepsin S elicits itch and signals via protease-activated receptors

Journal of Investigative Dermatology

Volumn 130, Issue 5, 2010, Pages 1468-1470

  Reddy, Vemuri B ^a   Shimada, Steven G ^b   Sikand, Parul ^b   Lamotte, Robert H ^b   Lerner, Ethan A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; CATHEPSIN S; CYSTEINE PROTEINASE; ENDOSTATIN; G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON; HISTAMINE; KALLIKREIN; LIGAND; MUCUNAIN; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 4; SERINE PROTEINASE; TRYPTASE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANTINOCICEPTION; ASTHMA; GENE EXPRESSION; HUMAN; INFLAMMATION; KERATINOCYTE; LEGUME; LETTER; MEDIATOR; NERVE FIBER; NONHUMAN; PERIPHERAL NERVE INJURY; PH; PRIORITY JOURNAL; PRURITUS; PSORIASIS; SENSATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SKIN DISEASE; SKIN INFLAMMATION; SKIN NERVE; SPINAL GANGLION; UPREGULATION; URTICARIA; VELVET BEAN;

EID: 77951093867     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.430     Document Type: Letter

References (17)

1. Asfaha S, Cenac N, Houle S et al. (2007) Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. Br J Pharmacol 150:176-185
2. Asokananthan N, Graham PT, Stewart DJ et al. (2002) House dust mite allergens induce pro-inflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor(PAR)-2 and inactivates PAR-1. J Immunol 169: 4572-8
3. Barclay J, Clark AK, Ganju P et al. (2007) Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain 130:225-234
4. Felbor U, Dreier L, Bryant RA et al. (2000) Secreted cathepsin L generates endostatin from collagen XVIII. EMBO J 19:1187-1194
5. Hachem JP, Houben E, Crumrine D et al. (2006) Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Der-matol 126:2074-2086
6. Ikoma A, Steinhoff M, Ständer S et al. (2006) The neurobiology of itch. Nat Rev Neurosci 7:535-547
7. Johanek LM, Meyer RA, Friedman RM et al. (2008) A role for polymodal C-fiber afferents in nonhistaminergic itch. J Neurosci 28: 7659-7669
8. Nakagawa TY, Brissette WH, Lira PD et al. (1999) Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity 10:207-217
9. Namer B, Carr R, Johanek LM et al. (2008) Separate peripheral pathways for pruritus in man. J Neurophysiol 100:2062-2069
10. Oikonomopoulou K, Hansen KK, Saifeddine M et al. (2006) Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs). Biol Chem 387:817-824
11. Reddy VB, Iuga AO, Shimada S et al. (2008) Cowhage evoked itch is mediated by a novel cysteine protease\a ligand of protease activated receptors. J Neurosci 28:4331-4335
12. Schwarz G, Boehncke WH, Braun M et al. (2002) Cathepsin S activity is detectable in human keratinocytes and is selectively upregulated upon stimulation with interferon-g. J Invest Dermatol 119:44-49
13. Shpacovitch V, Feld M, Hollenberg MD et al. (2008) Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity. J Leukoc Biol 83: 1309-1322
14. Stefansson K, Brattsand M, Roosterman D et al. (2008) Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases. J Invest Dermatol 128:18-25
15. Steinhoff M, Vergnolle N, Young SH et al. (2000) Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechnism. Nat Med 6:151-158
16. Steinhoff M, Neisius U, Ikoma A et al. (2003) Proteinase-activated receptor 2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 23:6176-6180
17. Tsujii K, Andoh T, Lee JB et al. (2008) Activation of proteinase-activated receptors induces itch-associated responses through histamine-dependent and independent pathways in mice. J Pharmacol Sci 108:385-388