Inhibitor of κB kinase β regulates redox homeostasis by controlling the constitutive levels of glutathione

Molecular Pharmacology

Volumn 77, Issue 5, 2010, Pages 784-792

  Peng, Zhimin ^a   Geh, Esmond ^a   Chen, Liang ^a   Meng, Qinghang ^a   Fan, Yunxia ^a   Sartor, Maureen ^a   Shertzer, Howard G ^a   Liu, Zheng Gang ^b   Puga, Alvaro ^a   Xia, Ying ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; 4 METHYL N1 (3 PHENYLPROPYL)BENZENE 1,2 DIAMINE; [5 (4 FLUOROPHENYL) 2 UREIDO]THIOPHENE 3 CARBOXAMIDE; ARSENITE SODIUM; CYTOCHROME P450 2E1; ETOPOSIDE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; HYDROGEN PEROXIDE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JSH 23; NOCODAZOLE; PACLITAXEL; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; I KAPPA B KINASE; IKBKB PROTEIN, MOUSE; LUCIFERASE; PRIMER DNA; REACTIVE OXYGEN METABOLITE;

ADENOVIRUS INFECTION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INACTIVATION; FIBROBLAST; GENE EXPRESSION; HOMEOSTASIS; IMMUNOMODULATION; INFLAMMATION; MOUSE; NONHUMAN; NULL CELL; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; OXIDATION REDUCTION REACTION; PLASMID; REPORTER GENE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; DNA PRIMERS; GENES, REPORTER; GLUTATHIONE; HOMEOSTASIS; I-KAPPA B KINASE; LUCIFERASES; MICE; MICE, KNOCKOUT; NF-KAPPA B; OXIDATION-REDUCTION; PLASMIDS; REACTIVE OXYGEN SPECIES;

EID: 77951045225     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.061424     Document Type: Article

References (38)

1. Alexandre J, Batteux F, Nicco C, Chéreau C, Laurent A, Guillevin L, Weill B, and Goldwasser F (2006) Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int J Cancer 119:41-48.
2. Beg AA, Sha WC, Bronson RT, Ghosh S, and Baltimore D (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376:167-170.
3. Boitier E, Merad-Boudia M, Guguen-Guillouzo C, Defer N, Ceballos-Picot I, Leroux JP, and Marsac C (1995) Impairment of the mitochondrial respiratory chain activity in diethylnitrosamine-induced rat hepatomas: possible involvement of oxygen free radicals. Cancer Res 55:3028-3035.
4. 2-terminal kinase activation induced by arsenic. Cancer Res 63:7689-7693.
5. Cosulich SC, James NH, Needham MR, Newham PP, Bundell KR, and Roberts RA (2000) A dominant negative form of IKK2 prevents suppression of apoptosis by the peroxisome proliferator nafenopin. Carcinogenesis 21:1757-1760.
6. Hayden MS and Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132:344-362.
7. Hoffer A, Chang CY, and Puga A (1996) Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways. Toxicol Appl Pharmacol 141:238-247. (Pubitemid 26414370)
8. Jeyapaul J and Jaiswal AK (2000) Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of gamma-glutamylcysteine synthetase heavy subunit gene. Biochem Pharmacol 59:1433-1439. (Pubitemid 30177361)
9. Kamata H, Honda S, Maeda S, Chang L, Hirata H, and Karin M (2005) Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120:649-661. (Pubitemid 40343077)
10. Kann S, Estes C, Reichard JF, Huang MY, Sartor MA, Schwemberger S, Chen Y, Dalton TP, Shertzer HG, Xia Y, et al. (2005) Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol Sci 87:365-384. (Pubitemid 41300684)
11. Klipper-Aurbach Y, Wasserman M, Braunspiegel-Weintrob N, Borstein D, Peleg S, Assa S, Karp M, Benjamini Y, Hochberg Y, and Laron Z (1995) Mathematical formulae for the prediction of the residual beta cell function during the first two years of disease in children and adolescents with insulin-dependent diabetes mellitus. Med Hypotheses 45:486-490.
12. Kurosu T, Fukuda T, Miki T, and Miura O (2003) BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells. Oncogene 22:4459-4468. (Pubitemid 36920689)
13. Lin Y, Choksi S, Shen HM, Yang QF, Hur GM, Kim YS, Tran JH, Nedospasov SA, and Liu ZG (2004) Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem 279:10822-10828. (Pubitemid 38372695)
14. Lu SC (2009) Regulation of glutathione synthesis. Mol Aspects Med 30:42-59.
15. Maeda S, Kamata H, Luo JL, Leffert H, and Karin M (2005) IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121:977-990. (Pubitemid 40884391)
16. Mantena SK and Katiyar SK (2006) Grape seed proanthocyanidins inhibit UV-radiation- induced oxidative stress and activation of MAPK and NF-kappaB signaling in human epidermal keratinocytes. Free Radic Biol Med 40:1603-1614.
17. Meister A and Anderson ME (1983) Glutathione. Annu Rev Biochem 52:711-760.
18. Nagashima R, Sugiyama C, Yoneyama M, Kuramoto N, Kawada K, and Ogita K (2007) Acoustic overstimulation facilitates the expression of glutamate-cysteine ligase catalytic subunit probably through enhanced DNA binding of activator protein-1 and/or NF-kappaB in the murine cochlea. Neurochem Int 51:209-215. (Pubitemid 47176702)
19. O'Dea EL, Kearns JD, and Hoffmann A (2008) UV as an amplifier rather than inducer of NF-kappaB activity. Mol Cell 30:632-641.
20. Pahl HL (1999) Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18:6853-6866.
21. Peng Z, Peng L, Fan Y, Zandi E, Shertzer HG, and Xia Y (2007) A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity. J Biol Chem 282:21487-21496. (Pubitemid 47099968)
22. Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, Jayawardena S, De Smaele E, Cong R, Beaumont C, et al. (2004) Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 119:529-542. (Pubitemid 39482352)
23. Ralph SJ (2008) Arsenic-based antineoplastic drugs and their mechanisms of action. Met Based Drugs 2008:260146.
24. Sakon S, Xue X, Takekawa M, Sasazuki T, Okazaki T, Kojima Y, Piao JH, Yagita H, Okumura K, Doi T, et al. (2003) NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J 22:3898-3909. (Pubitemid 36975716)
25. Schnekenburger M, Talaska G, and Puga A (2007) Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. Mol Cell Biol 27:7089-7101. (Pubitemid 47549747)
26. Senft AP, Dalton TP, and Shertzer HG (2000) Determining glutathione and glutathione disulfide using the fluorescence probe o-phthalaldehyde. Anal Biochem 280:80-86.
27. Shertzer HG, Clay CD, Genter MB, Chames MC, Schneider SN, Oakley GG, Nebert DW, and Dalton TP (2004) Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes. Free Radic Biol Med 36:618-631.
28. Sierra-Rivera E, Meredith MJ, Summar ML, Smith MD, Voorhees GJ, Stoffel CM, and Freeman ML (1994) Genes regulating glutathione concentrations in X-ray-transformed rat embryo fibroblasts: changes in gamma-glutamylcysteine synthetase and gamma-glutamyltranspeptidase expression. Carcinogenesis 15:1301-1307. (Pubitemid 24217679)
29. Smyth GK (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3:Article 3.
30. Taniguchi T, Takahashi M, Shinohara F, Sato T, Echigo S, and Rikiishi H (2005) Involvement of NF-kappaB and mitochondrial pathways in docetaxel-induced apoptosis of human oral squamous cell carcinoma. Int J Mol Med 15:667-673.
31. Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, et al. (2000) NAK is an IkappaB kinase-activating kinase. Nature 404:778-782.
32. Townsend DM, Tew KD, and Tapiero H (2003) The importance of glutathione in human disease. Biomed Pharmacother 57:145-155.
33. Urata Y, Yamamoto H, Goto S, Tsushima H, Akazawa S, Yamashita S, Nagataki S, and Kondo T (1996) Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells. J Biol Chem 271:15146-15152. (Pubitemid 26194994)
34. Varbiro G, Veres B, Gallyas F Jr, and Sumegi B (2001) Direct effect of Taxol on free radical formation and mitochondrial permeability transition. Free Radic Biol Med 31:548-558. (Pubitemid 32728442)
35. Watson WH and Jones DP (2003) Oxidation of nuclear thioredoxin during oxidative stress. FEBS Lett 543:144-147.
36. Yang H, Magilnick N, Lee C, Kalmaz D, Ou X, Chan JY, and Lu SC (2005a) Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. Mol Cell Biol 25:5933-5946. (Pubitemid 40949988)
37. Yang H, Magilnick N, Ou X, and Lu SC (2005b) Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1. Biochem J 391:399-408. (Pubitemid 41532438)
38. Yang H, Wang J, Huang ZZ, Ou X, and Lu SC (2001) Cloning and characterization of the 5′-flanking region of the rat glutamate-cysteine ligase catalytic subunit. Biochem J 357:447-455. (Pubitemid 32701781)