Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity

Molecular Nutrition and Food Research

Volumn 54, Issue 4, 2010, Pages 516-524

  Toyohira, Yumiko ^a   Ueno, Susumu ^a   Tsutsui, Masato ^a   Itoh, Hideaki ^a   Sakai, Norio ^b   Saito, Naoaki ^c   Takahashi, Kojiro ^d   Yanagihara, Nobuyuki ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c KOBE UNIVERSITY   (Japan)

^d UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Genistein; Noradrenaline transporter; Serotonin transporter; Tyrosine kinase inhibition; Up regulation

Indexed keywords

DRUG DERIVATIVE; ENZYME INHIBITOR; ESTRADIOL; ESTROGEN RECEPTOR; FLUOXETINE; FULVESTRANT; GENISTEIN; NISOXETINE; NORADRENALIN; NORADRENALIN TRANSPORTER; PHYTOESTROGEN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; SEROTONIN; SEROTONIN TRANSPORTER; TRITIUM; VANADIC ACID;

ANIMAL; ARTICLE; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; NEUROBLASTOMA; PHYSIOLOGY; SOYBEAN; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME INHIBITORS; ESTRADIOL; FLUOXETINE; GENISTEIN; HUMANS; NEUROBLASTOMA; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PHYTOESTROGENS; PROTEIN TYROSINE PHOSPHATASES; PROTEIN-TYROSINE KINASES; RECEPTORS, ESTROGEN; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOYBEANS; TRANSFECTION; TRITIUM; VANADATES;

EID: 77951042497     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200900167     Document Type: Article

References (41)

1. Yamazaki, I., Shino, A., Shimizu, Y., Tsukuda, R. et al. Effect of ipriflavone on glucocorticoid-induced osteoporosis in rats. Life Sci. 1986, 38, 951-958.
2. Arjmandi, B. H., Sohn, E., Juma, S., Murthy, S. R., Daggy, B. P., Native and partially hydrolyzed psyllium have comparable effects on cholesterol metabolism in rats. J. Nutr. 1997, 127, 463-469.
3. Adlercreutz, H., Hamalainen, E., Gorbach, S., Goldin, B., Dietary phyto-oestrogens and the menopause in Japan. Lancet 1992, 339, 1233.
4. Messina, M. J., Persky, V., Setchell, K. D., Barnes, S., Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr. Cancer 1994, 21, 113-131.
5. Kurzer, M. S., Xu, X., Dietary phytoestrogens. Annu. Rev. Nutr. 1997, 17, 353-381.
6. Falkenstein, E., Tillmann, H. C., Christ, M., Feuring, M., Wehling, M., Multiple actions of steroid hormones--a focus on rapid, nongenomic effects. Pharmacol. Rev. 2000, 52, 513-556.
7. Wehling, M., Specific, nongenomic actions of steroid hormones. Annu. Rev. Physiol. 1997, 59, 365-393.
8. Uki, M., Nabekura, J., Akaike, N., Suppression of the nicotinic acetylcholine response in rat superior cervical ganglionic neurons by steroids. J. Neurochem. 1999,72, 808-814.
9. Chang, A. S., Chang, S. M., Nongenomic steroidal modulation of high-affinity serotonin transport. Biochim. Biophys. Acta 1999, 1417, 157-166.
10. Kim, Y. J., Hur, E. M., Park, T. J., Kim, K. T., Nongenomic inhibition of catecholamine secretion by 17b-estradiol in PC12 cells. J. Neurochem. 2000, 74, 2490-2496.
11. Duffy, C., Perez, K., Partridge, A., Implications of phytoestrogen intake for breast cancer. CA Cancer J. Clin. 2007, 57, 260-277.
12. O'Dell, T. J., Kandel, E. R., Grant, S. G. N., Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 1991, 353, 558-560.
13. Cho, C. H., Song, W., Leitzell, K., Teo, E. et al. Rapid upregulation of g7 nicotinic acetylcholine receptors by tyrosine dephosphorylation. J. Neurosci. 2005, 25, 3712-3723.
14. Law, R. M., Stafford, A., Quick, M. W., Functional regulation of g-aminobutyric acid transporters by direct tyrosine phosphorylation. J. Biol. Chem. 2000, 275, 23986-23991.
15. Amara, S. G., Sonders, M. S., Zahniser, N. R., Povlock, S. L., Daniels, G. M., Molecular physiology and regulation of catecholamine transporters. Adv. Pharmacol. 1998, 42, 164-168.
16. Blakely, R. D., Bauman, A. L., Biogenic amine transporters: regulation in flux. Curr. Opin. Neurobiol. 2000, 10, 328-336.
17. Rudnick, G., Wall, S. C., Non-neurotoxic amphetamine derivatives release serotonin through serotonin transporters. Mol. Pharmacol. 1993, 43, 271-276.
18. Xu, F., Gainetdinov, R. R., Wetsel, W. C., Jones, S. R. et al. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat. Neurosci. 2000, 3, 465-471.
19. Toyohira, Y., Utsunomiya, K., Ueno, S., Minami, K. et al. Inhibition of the norepinephrine transporter function in cultured bovine adrenal medullary cells by bisphenol A. Biochem. Pharmacol. 2003, 65, 2049-2054.
20. Apparsundaram, S., Sung, U., Price, R. D., Blakely, R. D., Trafficking-dependent and-independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells. J. Pharmacol. Exp. Ther. 2001, 299, 666-677.
21. Ofir, R., Tamir, S., Khatib, S., Vaya, J., Inhibition of serotonin re-uptake by licorice constituents. J. Mol. Neurosci. 2003,20,135-140.
22. Morikawa, O., Sakai, N., Obara, H., Saito, N., Effects of interferon-a, interferon-g and cAMP on the transcriptional regulation of the serotonin transporter. Eur. J. Pharmacol. 1998,349,317-324.
23. Apparsundaram, S., Galli, A., DeFelice, L. J., Hartzell, H. C., Blakely, R. D., Acute regulation of norepinephrine transport: I. protein kinase C-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells. J. Pharmacol. Exp. Ther. 1998, 287, 733-743.
24. Beato, M., Herrlich, P., Schutz, G., Steroid hormone receptors: many actors in search of a plot. Cell 1995, 83, 851-857.
25. Kousteni, S., Bellido, T., Plotkin, L. I., O'Brien, C. A. et al. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 2001, 104, 719-730.
26. Norfleet, A. M., Clarke, C. H., Gametchu, B., Watson, C. S., Antibodies to the estrogen receptor-a modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors. FASEB J. 2000, 14, 157-165.
27. Toran-Allerand, C. D., Guan, X., MacLusky, N. J., Horvath, T. L. et al. ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J. Neurosci. 2002, 22,8391-8401.
28. Carmeci, C., Thompson, D. A., Ring, H. Z., Francke, U., Weigel, R. J., Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics 1997, 45, 607-617.
29. Yanagihara, N., Liu, M., Toyohira, Y., Tsutsui, M. et al. Stimulation of catecholamine synthesis through unique estrogen receptors in the bovine adrenomedullary plasma membrane by17b-estradiol. Biochem. Biophys. Res. Commun. 2006, 339, 548-553.
30. Liu, M., Yanagihara, N., Toyohira, Y., Tsutsui, M. et al. Dual effects of daidzein, a soy isoflavone, on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells. Endocrinology 2007, 148, 5348-5354.
31. Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H. et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 1987, 262, 5592-5595.
32. Prasad, P. D., Torres-Zamorano, V., Kekuda, R., Leibach, F. H., Ganapathy, V., Functional link between tyrosine phosphorylation and human serotonin transporter gene expression. Eur. J. Pharmacol. 1997, 325, 85-92.
33. Doolen, S., Zahniser, N. R., Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes. J. Pharmacol. Exp. Ther. 2001, 296, 931-938.
34. Kano, M., Takayanagi, T., Harada, K., Sawada, S., Ishikawa, F., Bioavailability of isoflavones after ingestion of soy beverages in healthy adults. J. Nutr. 2006, 136, 2291-2296.
35. Arai, Y., Uehara, M., Sato, Y., Kimira, M. et al. Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. J. Epidemiol. 2000, 10, 127-135.
36. Morton, M. S., Arisaka, O., Miyake, N., Morgan, L. D., Evans, B. A., Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. J. Nutr. 2002, 132,3168-3171.
37. Adlercreutz, H., Markkanen, H., Watanabe, S., Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 1993, 342, 1209-1210.
38. Chin-Dusting, J. P., Fisher, L. J., Lewis, T. V., Piekarska, A. et al. The vascular activity of some isoflavone metabolites: implications for a cardioprotective role. Br. J. Pharmacol. 2001,133,595-605.
39. Toma, C., Jensen, P. E., Prieto, D., Hughes, A. et al. Effects of tyrosine kinase inhibitors on the contractility of rat mesenteric resistance arteries. Br. J. Pharmacol. 1995, 114, 1266-1272.
40. Best, N. R., Rees, M. P., Barlow, D. H., Cowen, P. J., Effect of estradiol implant on noradrenergic function and mood in menopausal subjects. Psychoneuroendocrinology 1992, 17, 87-93.
41. Joffe, H., Cohen, L. S., Estrogen, serotonin, and mood disturbance: where is the therapeutic bridge? Biol. Psychiatry 1998, 44, 798-811.