Identification of phosphorylated residues on varicella-zoster virus immediate-early protein ORF63

Journal of General Virology

Volumn 91, Issue 5, 2010, Pages 1133-1137

  Mueller, Niklaus H ^a   Walters, Matthew S ^b   Marcus, Roland A ^a   Graf, Laurie L ^a   Prenni, Jessica ^c   Gilden, Don ^a   Silverstein, Saul J ^b   Cohrs, Randall ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b Columbia University ^*  (United States)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OPEN READING FRAME 63 PROTEIN; PHOSPHOTRANSFERASE; SERINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; EMBRYO; EXTRACTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; VARICELLA ZOSTER VIRUS; VIRUS INFECTION;

AMINO ACID SEQUENCE; CELL LINE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HERPESVIRUS 3, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION;

HUMAN HERPESVIRUS 3;

EID: 77951039948     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.019067-0     Document Type: Article

References (34)

1. Ambagala, A. P. & Cohen, J. I. (2007). Varicella-zoster virus IE63, a major viral latency protein, is required to inhibit the alpha interferon-induced antiviral response. J Virol 81, 7844-7851.
2. Ambagala, A. P., Bosma, T., Ali, M. A., Poustovoitov, M., Chen, J. J., Gershon, M. D., Adams, P. D. & Cohen, J. I. (2009). Varicella-zoster virus immediate-early 63 protein interacts with human antisilencing function 1 protein and alters its ability to bind histones h3.1 and h3.3. J Virol 83, 200-209.
3. Baiker, A., Bagowski, C., Ito, H., Sommer, M., Zerboni, L., Fabel, K., Hay, J., Ruyechan, W. T. & Arvin, A. M. (2004). The immediate-early 63 protein of varicella-zoster virus: analysis of functional domains required for replication in vitro and for T-cell and skin tropism in the SCIDhu model in vivo. J Virol 78, 1181-1194. (Pubitemid 38095828)
4. Bontems, S., Di Valentin, E., Baudoux, L., Rentier, B., Sadzot-Delvaux, C. & Piette, J. (2002). Phosphorylation of varicella-zoster virus IE63 protein by casein kinases influences its cellular localization and gene regulation activity. J Biol Chem 277, 21050-21060. (Pubitemid 34967416)
5. Chen, J. J., Gershon, A. A., Li, Z. S., Lungu, O. & Gershon, M. D. (2003). Latent and lytic infection of isolated guinea pig enteric ganglia by varicella zoster virus. J Med Virol 70, S71-S78. (Pubitemid 36368850)
6. Cohen, J. I., Cox, E., Pesnicak, L., Srinivas, S. & Krogmann, T. (2004). The varicella-zoster virus open reading frame 63 latency-associated protein is critical for establishment of latency. J Virol 78, 11833-11840. (Pubitemid 39390770)
7. Cohen, J. I., Krogmann, T., Bontems, S., Sadzot-Delvaux, C. & Pesnicak, L. (2005). Regions of the varicella-zoster virus open reading frame 63 latency-associated protein important for replication in vitro are also critical for efficient establishment of latency. J Virol 79, 5069-5077. (Pubitemid 40464257)
8. Cohrs, R. J. & Gilden, D. H. (2007). Prevalence and abundance of latently transcribed varicella-zoster virus genes in human ganglia. J Virol 81, 2950-2956.
9. Cohrs, R. J., Barbour, M. & Gilden, D. H. (1996). Varicella-zoster virus (VZV) transcription during latency in human ganglia: detection of transcripts mapping to genes 21, 29, 62, and 63 in a cDNA library enriched for VZV RNA. J Virol 70, 2789-2796. (Pubitemid 26121892)
10. Cohrs, R. J., Randall, J., Smith, J., Gilden, D. H., Dabrowski, C., van Der, K. H. & Tal-Singer, R. (2000). Analysis of individual human trigeminal ganglia for latent herpes simplex virus type 1 and varicella-zoster virus nucleic acids using real-time PCR. J Virol 74, 11464-11471. (Pubitemid 32222293)
11. Cohrs, R. J., Wischer, J., Essman, C. & Gilden, D. H. (2002). Characterization of varicella-zoster virus gene 21 and 29 proteins in infected cells. J Virol 76, 7228-7238.
12. Debrus, S., Sadzot-Delvaux, C., Nikkels, A. F., Piette, J. & Rentier, B. (1995). Varicella-zoster virus gene 63 encodes an immediate-early protein that is abundantly expressed during latency. J Virol 69, 3240-3245.
13. Di Valentin, E., Bontems, S., Habran, L., Jolois, O., Markine-Goriaynoff, N., Vanderplasschen, A., Sadzot-Delvaux, C. & Piette, J. (2005). Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex. Biol Chem 386, 255-267. (Pubitemid 40485431)
14. Gary, L., Gilden, D. H. & Cohrs, R. J. (2006). Epigenetic regulation of varicella-zoster virus open reading frames 62 and 63 in latently infected human trigeminal ganglia. J Virol 80, 4921-4926.
15. Gilden, D. H., Cohrs, R. J. & Mahalingam, R. (2003). Clinical and molecular pathogenesis of varicella virus infection. Viral Immunol 16, 243-258. (Pubitemid 37229539)
16. Grinfeld, E. & Kennedy, P. G. (2004). Translation of varicella-zoster virus genes during human ganglionic latency. Virus Genes 29, 317-319. (Pubitemid 40941264)
17. Grose, C. & Brunel, P. A. (1978). Varicella-zoster virus: isolation and propagation in human melanoma cells at 36 and 32 degrees C. Infect Immun 19, 199-203. (Pubitemid 8275226)
18. Habran, L., Bontems, S., Di Valentin, E., Sadzot-Delvaux, C. & Piette, J. (2005). Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity. J Biol Chem 280, 29135-29143. (Pubitemid 41161364)
19. Heineman, T. C. & Cohen, J. I. (1995). The varicella-zoster virus (VZV) open reading frame 47 (ORF47) protein kinase is dispensable for viral replication and is not required for phosphorylation of ORF63 protein, the VZV homolog of herpes simplex virus ICP22. J Virol 69, 7367-7370.
20. Heineman, T. C., Seidel, K. & Cohen, J. I. (1996). The varicella-zoster virus ORF66 protein induces kinase activity and is dispensable for viral replication. J Virol 70, 7312-7317. (Pubitemid 26307459)
21. Jackers, P., Defechereux, P., Baudoux, L., Lambert, C., Massaer, M., Merville-Louis, M. P., Rentier, B. & Piette, J. (1992). Characterization of regulatory functions of the varicella-zoster virus gene 63-encoded protein. J Virol 66, 3899-3903.
22. Kennedy, P. G., Grinfeld, E. & Bell, J. E. (2000). Varicella-zoster virus gene expression in latently infected and explanted human ganglia. J Virol 74, 11893-11898. (Pubitemid 32222339)
23. Kennedy, P. G., Grinfeld, E., Bontems, S. & Sadzot-Delvaux, C. (2001). Varicella-zoster virus gene expression in latently infected rat dorsal root ganglia. Virology 289, 218-223. (Pubitemid 33141001)
24. Kenyon, T. K., Lynch, J., Hay, J., Ruyechan, W. & Grose, C. (2001). Varicella-zoster virus ORF47 protein serine kinase: characterization of a cloned, biologically active phosphotransferase and two viral substrates, ORF62 and ORF63. J Virol 75, 8854-8858. (Pubitemid 32768990)
25. Kinchington, P. R., Bookey, D. & Turse, S. E. (1995). The transcriptional regulatory proteins encoded by varicella-zoster virus open reading frames (ORFs) 4 and 63, but not ORF 61, are associated with purified virus particles. J Virol 69, 4274-4282.
26. Kost, R. G., Kupinsky, H. & Straus, S. E. (1995). Varicella-zoster virus gene 63: transcript mapping and regulatory activity. Virology 209, 218-224.
27. Lungu, O., Panagiotidis, C. A., Annunziato, P. W., Gershon, A. A. & Silverstein, S. J. (1998). Aberrant intracellular localization of varicella-zoster virus regulatory proteins during latency. Proc Natl Acad Sci U S A 95, 7080-7085. (Pubitemid 28278110)
28. Lynch, J. M., Kenyon, T. K., Grose, C., Hay, J. & Ruyechan, W. T. (2002). Physical and functional interaction between the varicella zoster virus IE63 and IE62 proteins. Virology 302, 71-82. (Pubitemid 35356856)
29. Mahalingam, R., Wellish, M., Cohrs, R., Debrus, S., Piette, J., Rentier, B. & Gilden, D. H. (1996). Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons. Proc Natl Acad Sci U S A 93, 2122-2124. (Pubitemid 26079891)
30. Messaoudi, I., Barron, A., Wellish, M., Engelmann, F., Legasse, A., Planer, S., Gilden, D., Nikolich-Zugich, J. & Mahalingam, R. (2009). Simian varicella virus infection of rhesus macaques recapitulates essential features of varicella zoster virus infection in humans. PLoS Pathog 5, e1000657.
31. Mueller, N. H., Graf, L. L., Orlicky, D., Gilden, D. & Cohrs, R. J. (2009). Phosphorylation of the nuclear form of varicella zoster virus immediate-early protein 63 by casein kinase II at serine 186. J Virol 83, 12094-12100.
32. Stevenson, D., Xue, M., Hay, J. & Ruyechan, W. T. (1996). Phosphorylation and nuclear localization of the varicella-zoster virus gene 63 protein. J Virol 70, 658-662. (Pubitemid 126508842)
33. Stolarov, J., Chang, K., Reiner, A., Rodgers, L., Hannon, G. J., Wigler, M. H. & Mittal, V. (2001). Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proc Natl Acad Sci U S A 98, 13043-13048. (Pubitemid 33051314)
34. Walters, M. S., Kyratsous, C. A., Wan, S. & Silverstein, S. (2008). Nuclear import of the varicella-zoster virus latency-associated protein ORF63 in primary neurons requires expression of the lytic protein ORF61 and occurs in a proteasome-dependent manner. J Virol 82, 8673-8686.