Alterations in fear response and spatial memory in pre- and post-natal zinc supplemented rats: Remediation by copper

Physiology and Behavior

Volumn 100, Issue 2, 2010, Pages 95-100

  Railey, Angela M ^a   Micheli, Teresa L ^a   Wanschura, Patricia B ^a   Flinn, Jane M ^a  

^a GEORGE MASON UNIVERSITY   (United States)

Author keywords

Anxiety; Behavior; Copper; Fear conditioning; Memory; Morris Water Maze; Zinc

Indexed keywords

CUPRIC CARBONATE; DRINKING WATER; INORGANIC SALT; UNCLASSIFIED DRUG; ZINC CARBONATE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; ASSOCIATION; CONDITIONING; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG MECHANISM; FEAR; LEARNING; MALE; MAZE TEST; MEMORY DISORDER; NONHUMAN; PERINATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; TASK PERFORMANCE;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CARBONATES; COPPER; CUES; EXTINCTION, PSYCHOLOGICAL; FEAR; FEMALE; FREEZING REACTION, CATALEPTIC; MALE; MAZE LEARNING; MEMORY DISORDERS; PHOTIC STIMULATION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; RETENTION (PSYCHOLOGY); SPACE PERCEPTION; ZINC COMPOUNDS;

EID: 77950950391     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2010.01.040     Document Type: Article

References (43)

1. Frederickson C.J., Suh S.W., Silva D., Thompson R.B. Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr 2000, 130(5S Suppl):1471S-1483S.
2. Vallee B., Falchuk K. The biochemical basis of zinc physiology. Physiol Rev 1993, 73:79-118.
3. Bitanhirwe B.K.Y., Cunningham M.G. Zinc: the brain's dark horse. Synapse 2009, 63:71029-71049.
4. Sensi S.L., Paoletti P., Bush A.I., Sekler I. Zinc in the physiology and pathology of the CNS. Nat Rev Neurosci 2009, 10:780-791.
5. Maret W., Sanstead H.H. Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol 2006, 20(1):3-18.
6. Igic P.G., Lee E., Harper W., Roach K.W. Toxic effects associated with consumption of zinc. Mayo Clin Proc 2002, 77(7):713-716.
7. Age-Related Eye Disease Study Research ciGroup AREDS report No. 7. J Nutr 2001, 132(4):697-702.
8. Nations S.P., Boyer P.J., Love L.A., Burritt M.F., Butz J.A., Wolfe G.I., Hynan L.S., Reisch J., Trivedi J.R. Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease. Neurology 2008, 71(9):639-643.
9. Reeves P.G., DeMars L.C.S., Johnson W.T., Lukaski H.C. Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. J Nutr 2005, 135:92-98.
10. Reeves P., DeMars L. Copper deficiency reduces iron absorption and biological half-life in male rats. J Nutr 2004, 134:1953-1957.
11. NIH state-of-the-science conference on multivitamin/mineral supplements and chronic disease prevention (April 2006). Retrieved May 17, 2006, from http://consensus.nih.gov/2006/2006multivitaminmineral505028html.htm.
12. Pal S., He K., Aizenman E. Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link?. Pflugers Arch 2004, 448(3):296-303.
13. Flinn J.M., Hunter D., Linkous D.H., Lanzirotti A., Smith L.N., Brightwell J.J., Jones B.F. Enhanced zinc consumption causes memory deficits and increased brain levels of zinc. Physiol Behav 2005, 83(5):793-803.
14. Turner T.Y., Soliman M.R. Effects of zinc on spatial reference memory and brain dopamine (D1) receptor binding kinetics in rats. Prog Neuropsychopharmacol Biol Psychiatry 2000, 24(7):1203-1217.
15. Chrosniak L., Smith L., McDonald C., Flinn J., Jones B. Effects of enhanced zinc and copper in drinking water on spatial memory and fear conditioning. J Geochem Explor 2006, 88(103):91-94.
16. Knight J. Metalheads. New Sci 2000, 2253:37-39.
17. Micheli T.L., Mozogova O.I., Freese A.L., Coleman K., Nguyen T., Railey A.M., Chrosniak L., Wanschura P.B., Flinn J.M. Behavioral and histological assessment following pre- and post-natal zinc. Presented at SFN, Washington, DC November 2008.
18. Hunt C.D., Idso J.P. Moderate copper deprivation during gestation and lactation affects dentate gyrus and hippocampal maturation in immature male rats. J Nutr 1995, 125(10):2700-2710.
19. Penland J.G., Milne D.B., Davis C.W. Moderately high zinc intake impairs verbal memory of healthy postmenopausal women on a low copper diet. Trace elements in man and animals 2000, 10. Academic Press. A.M. Roussel, R.A. Anderson, A.E. Favrier (Eds.).
20. Farrar J.R., Hoss W., Herndon R.M., Kuzmiak M. Characterization of muscarinic cholinergic receptors in the brains of copper-deficient rats. J Neurosci 1985, 5(4):1083-1089.
21. Prohaska J.R., Bailey W.R. Persistent regional changes in brain copper, cuproenzymes and catecholamines following perinatal copper deficiency in mice. J Nutr 1993, 123(7):1226-1234.
22. Morris R.G.M. Development of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984, 11:47-60.
23. Quirk G.J. Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery. Learn Mem 2002, 9(6):402-407.
24. Harris J.A., Westbrook R.F. Evidence that GABA transmission mediates context-specific extinction of learned fear. Psychopharmacology (Berlin) 1998, 140(1):105-115.
25. Davis M., Myers K.M. The role of glutamate and gamma-aminobutyric acid in fear extinction: clinical implications for exposure therapy. Biol Psychiatry 2002, 52(10):998-1007.
26. Akirav I., Raizel H., Maroun M. Enhancement of conditioned fear extinction by infusion of the GABA(A) agonist muscimol into the rat prefrontal cortex and amygdala. Eur J NeuroSci 2006, 23(3):758-764.
27. Burgos-Robles A., Vidal-Gonzalez I., Santini E., Quirk G.J. Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex. Neuron 2007, 53(6):871-880.
28. Sotres-Bayon F., Bush D.E., LeDoux J.E. Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology 2007, 32(9):1929-1940.
29. Barberis A., Cherubini E., Mozrzymas J.W. Zinc inhibits miniature GABAergic currents by allosteric modulation of GABAA receptor gating. J Neurosci 2000, 20(23):8618-8627.
30. Peters S., Koh J., Choi D.W. Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons. Science 1987, 236(4801):589-593.
31. 2+ antagonize NMDA and GABA responses of hippocampal neurons. Nature 1987, 328:640-643.
32. Linthorst A.C., Reul J.M. Stress and the brain: solving the puzzle using microdialysis. Pharmacol Biochem Behav 2008, 90(2):163-173.
33. Garakani A., Mathew S.J., Charney D.S. Neurobiology of anxiety disorders and implications for treatment. Mt Sinai J Med 2006, 73(7):941-949.
34. Bruchey A.K., Shumake J., Gonzalez-Lima F. Network model of fear extinction and renewal functional pathways. Neuroscience 2007, 145(2):423-437.
35. Brown C.E., Dyck R.H. Distribution of zincergic neurons in the mouse forebrain. J Comp Neurol 2004, 479(2):156-167.
36. Cunningham M.G., Ames H.M., Christensen M.K., Sorensen J.C. Zincergic innervation of medial prefrontal cortex by basolateral projection neurons. NeuroReport 2007, 18(6):531-535.
37. Davis M. Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy. Eur J NeuroSci 2002, 16(3):395-398.
38. Kodirov S.A., Takizawa S., Joseph J., Kandel E., Shumyatsky G.P., Bolshakov V. Synaptically released zinc gates long-term potentiation in fear conditioning pathways. PNAS 2006, 103:15218-15223.
39. Conrad C.D., LeDoux J.E., Magarinos A.M., McEwen B.S. Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy. Behav Neurosci 1999, 113(5):902-913.
40. Okeda R., Gei S., Chen I., Okaniwa M., Shinomiva M., Matsubara O. Menkes' kinky hair disease: morphological and immunohistochemical comparison of two autopsied patients. Acta Neuropathologica 1991, 81(4):450-457.
41. Schlief M.L., West T., Craig A.M., Holtzman D.M., Gitlin J.D. Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. PNAS 2006, 103(40):14919-14924.
42. Cousins R.J. Metallothionein-aspects related to copper and zinc metabolism. J Inherit Metab Dis 1983, 6(Suppl 1):15-21.
43. Oestreicher P., Cousins R. Copper and zinc absorption in the rat: mechanism of mutual antagonism. J Nutr 1985, 115:159-166.