-
1
-
-
0036341359
-
Philadelphia chromosome-positive acute lymphoblastic leukemiaFcurrent concepts and future perspectives
-
Faderl S, Garcia-Manero G, Thomas DA, Kantarjian HM. Philadelphia chromosome-positive acute lymphoblastic leukemiaFcurrent concepts and future perspectives. Rev Clin Exp Hematol 2002; 6: 142-160.
-
(2002)
Rev Clin Exp Hematol
, vol.6
, pp. 142-160
-
-
Faderl, S.1
Garcia-Manero, G.2
Thomas, D.A.3
Kantarjian, H.M.4
-
2
-
-
14644425319
-
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
-
Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer 2005; 5: 172-183.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 172-183
-
-
Ren, R.1
-
3
-
-
0029683347
-
Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells
-
Danhauser-Riedl S, Warmuth M, Druker BJ, Emmerich B, Hallek M. Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells. Cancer Res 1996; 56: 3589-3596.
-
(1996)
Cancer Res
, vol.56
, pp. 3589-3596
-
-
Danhauser-Riedl, S.1
Warmuth, M.2
Druker, B.J.3
Emmerich, B.4
Hallek, M.5
-
4
-
-
0034674707
-
Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck
-
Lionberger JM, Wilson MB, Smithgall TE. Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck. J Biol Chem 2000; 275: 18581-18585.
-
(2000)
J Biol Chem
, vol.275
, pp. 18581-18585
-
-
Lionberger, J.M.1
Wilson, M.B.2
Smithgall, T.E.3
-
5
-
-
0036847027
-
The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells
-
Klejman A, Schreiner SJ, Nieborowska-Skorska M, Slupianek A, Wilson M, Smithgall TE et al. The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. EMBO J 2002; 21: 5766-57674.
-
(2002)
EMBO J
, vol.21
, pp. 5766-57674
-
-
Klejman, A.1
Schreiner, S.J.2
Nieborowska-Skorska, M.3
Slupianek, A.4
Wilson, M.5
Smithgall, T.E.6
-
6
-
-
2442465000
-
Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
-
Hu Y, Liu Y, Pelletier S, Buchdunger E, Warmuth M, Fabbro D et al. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet 2004; 36: 453-461.
-
(2004)
Nat Genet
, vol.36
, pp. 453-461
-
-
Hu, Y.1
Liu, Y.2
Pelletier, S.3
Buchdunger, E.4
Warmuth, M.5
Fabbro, D.6
-
7
-
-
0037438640
-
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
-
Donato NJ, Wu JY, Stapley J, Gallick G, Lin H, Arlinghaus R et al. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 2003; 101: 690-698.
-
(2003)
Blood
, vol.101
, pp. 690-698
-
-
Donato, N.J.1
Wu, J.Y.2
Stapley, J.3
Gallick, G.4
Lin, H.5
Arlinghaus, R.6
-
8
-
-
4544343214
-
A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2
-
Dai Y, Rahmani M, Corey SJ, Dent P, Grant S. A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. J Biol Chem 2004; 279: 34227-34239.
-
(2004)
J Biol Chem
, vol.279
, pp. 34227-34239
-
-
Dai, Y.1
Rahmani, M.2
Corey, S.J.3
Dent, P.4
Grant, S.5
-
9
-
-
38949134552
-
Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate
-
Brave M, Goodman V, Kaminskas E, Farrell A, Timmer W, Pope S et al. Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate. Clin Cancer Res 2008; 14: 352-359.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 352-359
-
-
Brave, M.1
Goodman, V.2
Kaminskas, E.3
Farrell, A.4
Timmer, W.5
Pope, S.6
-
10
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah NP, Tran C, Lee FY, Chen P, Norris D, Sawyers CL. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004; 305: 399-401.
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
11
-
-
21144451094
-
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
-
O'Hare T, Walters DK, Stoffregen EP, Jia T, Manley PW, Mestan J et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 2005; 65: 4500-4505.
-
(2005)
Cancer Res
, vol.65
, pp. 4500-4505
-
-
O'Hare, T.1
Walters, D.K.2
Stoffregen, E.P.3
Jia, T.4
Manley, P.W.5
Mestan, J.6
-
12
-
-
38549168926
-
Dasatinib: In chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia
-
Keam SJ. Dasatinib: in chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. BioDrugs 2008; 22: 59-69.
-
(2008)
BioDrugs
, vol.22
, pp. 59-69
-
-
Keam, S.J.1
-
13
-
-
46449088111
-
Metabolism and disposition of dasatinib after oral administration to humans
-
Christopher LJ, Cui D, Wu C, Luo R, Manning JA, Bonacorsi SJ et al. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos 2008; 36: 1357-1364.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 1357-1364
-
-
Christopher, L.J.1
Cui, D.2
Wu, C.3
Luo, R.4
Manning, J.A.5
Bonacorsi, S.J.6
-
14
-
-
56849117387
-
Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis
-
Shah NP, Kasap C, Weier C, Balbas M, Nicoll JM, Bleickardt E et al. Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis. Cancer Cell 2008; 14: 485-493.
-
(2008)
Cancer Cell
, vol.14
, pp. 485-493
-
-
Shah, N.P.1
Kasap, C.2
Weier, C.3
Balbas, M.4
Nicoll, J.M.5
Bleickardt, E.6
-
15
-
-
49249121723
-
Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and-intolerant chronic-phase chronic myeloid leukemia
-
Shah NP, Kantarjian HM, Kim DW, Réa D, Dorlhiac-Llacer PE, Milone JH et al. Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and-intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol 2008; 26: 3204-3212.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3204-3212
-
-
Shah, N.P.1
Kantarjian, H.M.2
Kim, D.W.3
Réa, D.4
Dorlhiac-Llacer, P.E.5
Milone, J.H.6
-
16
-
-
33744913814
-
Resistance to imatinib of Bcr/abl p190 lymphoblastic leukemia cells
-
Mishra S, Zhang B, Cunnick JM, Heisterkamp N, Groffen J. Resistance to imatinib of Bcr/abl p190 lymphoblastic leukemia cells. Cancer Res 2006; 66: 5387-5393.
-
(2006)
Cancer Res
, vol.66
, pp. 5387-5393
-
-
Mishra, S.1
Zhang, B.2
Cunnick, J.M.3
Heisterkamp, N.4
Groffen, J.5
-
17
-
-
37749053902
-
Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia
-
Kaur P, Feldhahn N, Zhang B, Trageser D, Müschen M, Pertz V et al. Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia. Mol Cancer 2007; 6: 67.
-
(2007)
Mol Cancer
, vol.6
, pp. 67
-
-
Kaur, P.1
Feldhahn, N.2
Zhang, B.3
Trageser, D.4
Müschen, M.5
Pertz, V.6
-
18
-
-
34249666766
-
Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells
-
Zhang B, Groffen J, Heisterkamp N. Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells. Leukemia 2007; 21: 1189-1197.
-
(2007)
Leukemia
, vol.21
, pp. 1189-1197
-
-
Zhang, B.1
Groffen, J.2
Heisterkamp, N.3
-
19
-
-
33845514847
-
Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2
-
Mishra S, Pertz V, Zhang B, Kaur P, Shimada H, Groffen J et al. Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2. Leukemia 2007; 21: 178-180.
-
(2007)
Leukemia
, vol.21
, pp. 178-180
-
-
Mishra, S.1
Pertz, V.2
Zhang, B.3
Kaur, P.4
Shimada, H.5
Groffen, J.6
-
20
-
-
0036850514
-
Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
-
Hochhaus A, Kreil S, Corbin AS, La Rosee P, Muller MC, Lahaye T et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002; 11: 2190-2196.
-
(2002)
Leukemia
, vol.11
, pp. 2190-2196
-
-
Hochhaus, A.1
Kreil, S.2
Corbin, A.S.3
La Rosee, P.4
Muller, M.C.5
Lahaye, T.6
-
21
-
-
19944428353
-
Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxy-ethyl)- piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K et al. Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxy-ethyl)-piperazin-1- yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004; 47: 6658-6661.
-
(2004)
J Med Chem
, vol.47
, pp. 6658-6661
-
-
Lombardo, L.J.1
Lee, F.Y.2
Chen, P.3
Norris, D.4
Barrish, J.C.5
Behnia, K.6
-
22
-
-
34248166041
-
Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells
-
Nam S, Williams A, Vultur A, List A, Bhalla K, Smith D et al. Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells. Mol Cancer Ther 2007; 6: 1400-1405.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1400-1405
-
-
Nam, S.1
Williams, A.2
Vultur, A.3
List, A.4
Bhalla, K.5
Smith, D.6
-
23
-
-
38349086394
-
CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
-
Jin L, Tabe Y, Konoplev S, Xu Y, Leysath CE, Lu H et al. CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol Cancer Ther 2008; 7: 48-58.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 48-58
-
-
Jin, L.1
Tabe, Y.2
Konoplev, S.3
Xu, Y.4
Leysath, C.E.5
Lu, H.6
-
24
-
-
14444272052
-
Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4
-
Signoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF et al. Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J Cell Biol 1997; 139: 651-664.
-
(1997)
J Cell Biol
, vol.139
, pp. 651-664
-
-
Signoret, N.1
Oldridge, J.2
Pelchen-Matthews, A.3
Klasse, P.J.4
Tran, T.5
Brass, L.F.6
-
25
-
-
0030830661
-
Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4
-
Schols D, Struyf S, Van Damme J, Esté JA, Henson G, De Clercq E. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J Exp Med 1997; 186: 1383-1388.
-
(1997)
J Exp Med
, vol.186
, pp. 1383-1388
-
-
Schols, D.1
Struyf, S.2
Van Damme, J.3
Esté, J.A.4
Henson, G.5
De Clercq, E.6
-
26
-
-
40849135781
-
Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines
-
Deguchi Y, Kimura S, Ashihara E, Niwa T, Hodohara K, Fujiyama Y et al. Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines. Leuk Res 2008; 32: 980-983.
-
(2008)
Leuk Res
, vol.32
, pp. 980-983
-
-
Deguchi, Y.1
Kimura, S.2
Ashihara, E.3
Niwa, T.4
Hodohara, K.5
Fujiyama, Y.6
-
27
-
-
58549088155
-
Activity of bosutinib, dasatinib, and nilotinib against 18 imatinib-resistant BCR/ABL mutants
-
Redaelli S, Piazza R, Rostagno R, Magistroni V, Perini P, Marega M et al. Activity of bosutinib, dasatinib, and nilotinib against 18 imatinib-resistant BCR/ABL mutants. J Clin Oncol 2009; 27: 469-471.
-
(2009)
J Clin Oncol
, vol.27
, pp. 469-471
-
-
Redaelli, S.1
Piazza, R.2
Rostagno, R.3
Magistroni, V.4
Perini, P.5
Marega, M.6
-
28
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
DOI 10.1056/NEJMoa055229
-
Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006; 354: 2531-2541. (Pubitemid 43882349)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.24
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
Donato, N.4
Nicoll, J.5
Paquette, R.6
Cortes, J.7
O'Brien, S.8
Nicaise, C.9
Bleickardt, E.10
Blackwood-Chirchir, M.A.11
Iyer, V.12
Chen, T.-T.13
Huang, F.14
Decillis, A.P.15
Sawyers, C.L.16
-
29
-
-
34948829146
-
Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: Interim results of a phase 2 study
-
Ottmann O, Dombret H, Martinelli G, Simonsson B, Guilhot F, Larson RA et al. Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood 2007; 110: 2309-2315.
-
(2007)
Blood
, vol.110
, pp. 2309-2315
-
-
Ottmann, O.1
Dombret, H.2
Martinelli, G.3
Simonsson, B.4
Guilhot, F.5
Larson, R.A.6
-
30
-
-
33750937577
-
Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
-
Hu Y, Swerdlow S, Duffy TM, Weinmann R, Lee FY, Li S. Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proc Natl Acad Sci USA 2006; 103: 16870-16875.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16870-16875
-
-
Hu, Y.1
Swerdlow, S.2
Duffy, T.M.3
Weinmann, R.4
Lee, F.Y.5
Li, S.6
-
31
-
-
58149171954
-
Characteristics of dasatinib-and imatinib-resistant chronic myelogenous leukemia cells
-
Okabe S, Tauchi T, Ohyashiki K. Characteristics of dasatinib-and imatinib-resistant chronic myelogenous leukemia cells. Clin Cancer Res 2008; 14: 6181-6186.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6181-6186
-
-
Okabe, S.1
Tauchi, T.2
Ohyashiki, K.3
-
32
-
-
49849092970
-
Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells
-
Weisberg E, Wright RD, McMillin DW, Mitsiades C, Ray A, Barrett R et al. Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells. Mol Cancer Ther 2008; 7: 1121-1129.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1121-1129
-
-
Weisberg, E.1
Wright, R.D.2
McMillin, D.W.3
Mitsiades, C.4
Ray, A.5
Barrett, R.6
-
33
-
-
0037450744
-
Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis
-
Glodek AM, Honczarenko M, Le Y, Campbell JJ, Silberstein LE. Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis. J Exp Med 2003; 197: 461-473.
-
(2003)
J Exp Med
, vol.197
, pp. 461-473
-
-
Glodek, A.M.1
Honczarenko, M.2
Le Campbell, Y.J.J.3
Silberstein, L.E.4
-
34
-
-
70350755790
-
Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to imatinib and nilotinib
-
Dillmann F, Veldwijk MR, Laufs S, Sperandio M, Calandra G, Wenz F et al. Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to imatinib and nilotinib. Leuk Lymph 2009; 50: 1676-1686.
-
(2009)
Leuk Lymph
, vol.50
, pp. 1676-1686
-
-
Dillmann, F.1
Veldwijk, M.R.2
Laufs, S.3
Sperandio, M.4
Calandra, G.5
Wenz, F.6
-
35
-
-
0032568918
-
Spontaneous and ligand-induced trafficking of CXC-chemokine receptor 4
-
Tarasova NI, Stauber RH, Michejda CJ. Spontaneous and ligand-induced trafficking of CXC-chemokine receptor 4. J Biol Chem 1998; 273: 15883-15886.
-
(1998)
J Biol Chem
, vol.273
, pp. 15883-15886
-
-
Tarasova, N.I.1
Stauber, R.H.2
Michejda, C.J.3
-
36
-
-
37749006707
-
Intracellular mediators of CXCR4-dependent signaling in T cells
-
Patrussi L, Baldari CT. Intracellular mediators of CXCR4-dependent signaling in T cells. Immunol Lett 2008; 115: 75-82.
-
(2008)
Immunol Lett
, vol.115
, pp. 75-82
-
-
Patrussi, L.1
Baldari, C.T.2
-
37
-
-
58149332686
-
Translating an antagonist of chemokine receptor CXCR4 from bench to bedside
-
Wong D, Kortz W. Translating an antagonist of chemokine receptor CXCR4 from bench to bedside. Clin Can Res 2008; 14: 7975-7980.
-
(2008)
Clin Can Res
, vol.14
, pp. 7975-7980
-
-
Wong, D.1
Kortz, W.2
|