Glycosylation-modified erythropoietin with improved half-life and biological activity

International Journal of Hematology

Volumn 91, Issue 2, 2010, Pages 238-244

  Su, Dongmei ^a   Zhao, Huilin ^b   Xia, Huanzhang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Institute for Shenyang Sunshine Pharmaceutical Co LTD   (China)

Author keywords

Erythropoiesis; Glycosylation; Human EPO; Reticulocytes; Sialic acid

Indexed keywords

ASPARAGINE; CARBOHYDRATE; ERYTHROPOIETIN; RECOMBINANT ERYTHROPOIETIN; SIALIC ACID; THREONINE; VALINE;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CARBOHYDRATE ANALYSIS; CHO CELL; CONTROLLED STUDY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; FEMALE; HEMATOCRIT; IMMUNORADIOMETRIC ASSAY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; RAT; RETICULOCYTE COUNT;

ANEMIA; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; ERYTHROPOIESIS; ERYTHROPOIETIN, RECOMBINANT; FEMALE; GLYCOSYLATION; HEMATOCRIT; HUMANS; MALE; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; N-ACETYLNEURAMINIC ACID; RATS; RATS, SPRAGUE-DAWLEY; RETICULOCYTES; TRANSFECTION;

EID: 77950916775     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-010-0496-x     Document Type: Article

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