Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: Differential expression of alternatively spliced variants in drosophila tissues

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 7857-7865

  Price, Nigel T ^a   Jackson, Vicky N ^a   Müller, Jürgen ^a   Moffat, Kevin ^b   Matthews, Karen L ^a   Orton, Tim ^a   Zammit, Victor A ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE SPLICING; AMINO ACID RESIDUES; DIFFERENTIAL EXPRESSIONS; DROSOPHILA MELANOGASTER; EXPRESSION LEVELS; FAT BODY; FLIGHT MUSCLE; FUNCTIONAL DIVERSITY; HETEROLOGOUS EXPRESSION; JACKSON; KINETIC PROPERTIES; MALONYL-COA; PCR ANALYSIS; PICHIA PASTORIS; SMALL REGION; SPLICE VARIANTS; SPLICED VARIANT;

AMINO ACIDS; HISTOLOGY; MAMMALS; MUSCLE; ORGANIC ACIDS;

GENE EXPRESSION;

CARNITINE PALMITOYLTRANSFERASE I; COMPLEMENTARY DNA; MESSENGER RNA; PALMITOYL COENZYME A; CARNITINE PALMITOYLTRANSFERASE; DROSOPHILA PROTEIN; ENZYME INHIBITOR; MALONYL COENZYME A;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; EXON; FAT BODY; FLIGHT MUSCLE; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; GENOME ANALYSIS; HETEROLOGOUS EXPRESSION; IMAGO; INSECT GENETICS; LARVA; NONHUMAN; NUCLEOTIDE SEQUENCE; PICHIA PASTORIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; YEAST; AEDES; AMINO ACID SEQUENCE; ANIMAL; ANOPHELES GAMBIAE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PICHIA;

DROSOPHILA MELANOGASTER; HEXAPODA; MAMMALIA; PICHIA PASTORIS;

AEDES; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; ANOPHELES GAMBIAE; BASE SEQUENCE; CARNITINE O-PALMITOYLTRANSFERASE; DNA, COMPLEMENTARY; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENZYME INHIBITORS; EXONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC VARIATION; KINETICS; MALONYL COENZYME A; MOLECULAR SEQUENCE DATA; PICHIA; RNA, MESSENGER; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 77950912128     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.072892     Document Type: Article

References (40)

1. Pande, S. V., and Murthy, M. S. (1989) Biochem. Cell Biol. 67, 671-673
2. Jackson, V. N., Cameron, J. M., Zammit, V. A., and Price, N. T. (1999) Biochem. J. 341, 483-489
3. Blencowe, B. J. (2006) Cell 126, 37-47
4. Zammit, V. A. (1999) Biochem. J. 343, 505-515
5. Lawson, D., Arensburger, P., Atkinson, P., Besansky, N. J., Bruggner, R. V., Butler, R., Campbell, K. S., Christophides, G. K., Christley, S., Dialynas, E., Emmert, D., Hammond, M., Hill, C. A., Kennedy, R. C., Lobo, N. F., MacCallum, M. R., Madey, G., Megy, K., Redmond, S., Russo, S., Severson, D. W., Stinson, E. O., Topalis, P., Zdobnov, E. M., Birney, E., Gelbart, W. M., Kafatos, F. C., Louis, C., and Collins, F. H. (2007) Nucleic Acids Res. 35, D503-D505
6. Tweedie, S., Ashburner, M., Falls, K., Leyland, P., McQuilton, P., Marygold, S., Millburn, G., Osumi-Sutherland, D., Schroeder, A., Seal, R., and Zhang, H. (2009) Nucleic Acids Res. 37, D555-D559
7. Jackson, V. N., Cameron, J. M., Fraser, F., Zammit, V. A., and Price, N. T. (2000) J. Biol. Chem. 275, 19560-19566
8. Jackson, V. N., Price, N. T., and Zammit, V. A. (2001) Biochemistry 40, 14629-14634
9. Jackson, V. N., Zammit, V. A., and Price, N. T. (2000) J. Biol. Chem. 275, 38410-38416
10. Celniker, S. E., Wheeler, D. A., Kronmiller, B., Carlson, J. W., Halpern, A., Patel, S., Adams, M., Champe, M., Dugan, S. P., Frise, E., Hodgson, A., George, R. A., Hoskins, R. A., Laverty, T., Muzny, D. M., Nelson, C. R., Pacleb, J. M., Park, S., Pfeiffer, B. D., Richards, S., Sodergren, E. J., Svirskas, R., Tabor, P. E., Wan, K., Stapleton, M., Sutton, G. G., Venter, C., Weinstock, G., Scherer, S. E., Myers, E. W., Gibbs, R. A., and Rubin, G. M. (2002) Genome Biol. 3, RESEARCH0079
11. Honeybee Genome Sequencing Consortium (2006) Nature 443, 931-949
12. Price, N. T., Jackson, V. N., van der Leij, F. R., Cameron, J. M., Travers, M. T., Bartelds, B., Huijkman, N. C., and Zammit, V. A. (2003) Biochem. J. 372, 871-879
13. van der Leij, F. R., Huijkman, N. C., Boomsma, C., Kuipers, J. R., and Bartelds, B. (2000) Mol. Genet. Metab. 71, 139-153
14. Price, N., van der Leij, F., Jackson, V., Corstorphine, C., Thomson, R., Sorensen, A., and Zammit, V. (2002) Genomics 80, 433-442
15. Candy, D. J., Becker, A., and Wegener, G. (1997) Comp. Biochem. Physiol. Biochem. 117, 497-512
16. Canavoso, L. E., Jouni, Z. E., Karnas, K. J., Pennington, J. E., and Wells, M. A. (2001) Annu. Rev. Nutr. 21, 23-46
17. Zammit, V. A., Price, N. T., Fraser, F., and Jackson, V. N. (2001) Biochem. Soc. Trans. 29, 287-292
18. Morillas, M., Clotet, J., Rubí, B., Serra, D., Asins, G., Ariño, J., and Hegardt, F. G. (2000) FEBS Lett. 466, 183-186
19. Morillas, M., Gómez-Puertas, P., Roca, R., Serra, D., Asins, G., Valencia, A., and Hegardt, F. G. (2001) J. Biol. Chem. 276, 45001-45008
20. López-Viñas, E., Bentebibel, A., Gurunathan, C., Morillas, M., de Arriaga, D., Serra, D., Asins, G., Hegardt, F. G., and Gómez-Puertas, P. (2007) J. Biol. Chem. 282, 18212-18224
21. Morillas, M., López-Viñas, E., Valencia, A., Serra, D., Gómez-Puertas, P., Hegardt, F. G., and Asins, G. (2004) Biochem. J. 379, 777-784
22. Morillas, M., Gómez-Puertas, P., Bentebibel, A., Sellés, E., Casals, N., Valencia, A., Hegardt, F. G., Asins, G., and Serra, D. (2003) J. Biol. Chem. 278, 9058-9063
23. Knudsen, J., Neergaard, T. B., Gaigg, B., Jensen, M. V., and Hansen, J. K. (2000) J. Nutr. 130, 294S-298S
24. Sierra, A. Y., Gratacós, E., Carrasco, P., Clotet, J., Ureña, J., Serra, D., Asins, G., Hegardt, F. G., and Casals, N. (2008) J. Biol. Chem. 283, 6878-6885
25. Morillas, M., Gómez-Puertas, P., Rubí, B., Clotet, J., Ariño, J., Valencia, A., Hegardt, F. G., Serra, D., and Asins, G. (2002) J. Biol. Chem. 277, 11473-11480
26. Wu, D., Govindasamy, L., Lian, W., Gu, Y., Kukar, T., Agbandje-McKenna, M., and McKenna, R. (2003) J. Biol. Chem. 278, 13159-13165
27. Jogl, G., and Tong, L. (2003) Cell 112, 113-122
28. Buglino, J., Onwueme, K. C., Ferreras, J. A., Quadri, L. E., and Lima, C. D. (2004) J. Biol. Chem. 279, 30634-30642
29. Hsiao, Y. S., Jogl, G., and Tong, L. (2004) J. Biol. Chem. 279, 31584-31589
30. Jogl, G., Hsiao, Y. S., and Tong, L. (2004) Ann. N.Y. Acad. Sci. 1033, 17-29
31. Jogl, G., Hsiao, Y. S., and Tong, L. (2005) J. Biol. Chem. 280, 738-744
32. Ma, X., Koepke, J., Panjikar, S., Fritzsch, G., and Stöckigt, J. (2005) J. Biol. Chem. 280, 13576-13583
33. Hsiao, Y. S., Jogl, G., Esser, V., and Tong, L. (2006) Biochem. Biophys. Res. Commun. 346, 974-980
34. Hsiao, Y. S., Jogl, G., and Tong, L. (2006) J. Biol. Chem. 281, 28480-28487
35. Gobin, S., Bonnefont, J. P., Prip-Buus, C., Mugnier, C., Ferrec, M., Demaugre, F., Saudubray, J. M., Rostane, H., Djouadi, F., Wilcox, W., Cederbaum, S., Haas, R., Nyhan, W. L., Green, A., Gray, G., Girard, J., and Thuillier, L. (2002) Hum. Genet. 111, 179-189
36. Park, E. A., Steffen, M. L., Song, S., Park, V. M., and Cook, G. A. (1998) Biochem. J. 330, 217-224
37. van der Leij, F. R., Cox, K. B., Jackson, V. N., Huijkman, N. C., Bartelds, B., Kuipers, J. R., Dijkhuizen, T., Terpstra, P., Wood, P. A., Zammit, V. A., and Price, N. T. (2002) J. Biol. Chem. 277, 26994-27005
38. Wang, D., Harrison, W., Buja, L. M., Elder, F. F., and McMillin, J. B. (1998) Genomics 48, 314-323
39. Yamazaki, N., Yamanaka, Y., Hashimoto, Y., Shinohara, Y., Shima, A., and Terada, H. (1997) FEBS Lett. 409, 401-406
40. Yu, G. S., Lu, Y. C., and Gulick, T. (1998) J. Biol. Chem. 273, 32901-32909