Complexity of gastric acid secretion revealed by targeted gene disruption in mice

Current Pharmaceutical Design

Volumn 16, Issue 10, 2010, Pages 1235-1240

  Chen, Duan ^a   Zhao, Chun Mei ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Acid secretion; CCK; Gastrin; Knockout mice; Receptors; Somatostatin; Stomach

Indexed keywords

CHOLECYSTOKININ; CHOLECYSTOKININ B RECEPTOR; GALANIN; GALANIN RECEPTOR 1; GASTRIN; HISTAMINE; SOMATOSTATIN RECEPTOR 2;

GENE DISRUPTION; GENETIC ENGINEERING; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HORMONAL REGULATION; KNOCKOUT MOUSE; MOUSE; NEUROMODULATION; NONHUMAN; PARACRINE SIGNALING; PEPTIC ULCER; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STOMACH ACID; STOMACH ACID SECRETION; STOMACH PARIETAL CELL;

ANIMALS; CHOLECYSTOKININ; GASTRIC ACID; GASTRINS; GENE TARGETING; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MICE; MICE, KNOCKOUT; PARACRINE COMMUNICATION; PEPTIC ULCER; RECEPTORS, SOMATOSTATIN; STOMACH NEOPLASMS;

EID: 77950887804     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210790945904     Document Type: Review

References (49)

1. Beumont W. Experiments and observations on the gastric juice and the physiology of digestion. Plattsburgy, NY: Dover Publication 1833.
2. Chen D, Zhao CM. Genetically engineered mice: a new paradigm to study gastric physiology. Curr Opin Gastroenterol 2007; 23: 602-606.
3. Spicer Z, Miller ML, Andringa A, Riddle TM, Duffy JJ, Doetschman T, et al. Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. J Biol Chem 2000; 275: 21555-21565.
4. Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, et al. The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J Biol Chem 2006; 281: 23740-23747. (Pubitemid 44274149)
5. - exchanger are achlorhydric. J Biol Chem 2004; 279: 30531-30539.
6. Recalde S, Muruzabal F, Looije N, Kunne C, Burrell MA, Saez E, et al. Inefficient chronic activation of parietal cells in Ae2a,b(-/-) mice. Am J Pathol 2006; 169: 165-176.
7. + exchanger. J Biol Chem 2005; 280: 12781-12789.
8. 2 receptor-deficient mice. J Clin Invest 2000; 105: 1741-1749.
9. Aihara T, Fujishita T, Kanatani K, Furutani K, Nakamura E, Taketo MM, et al. Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice. Gastroenterology 2003; 125: 1774-1784. (Pubitemid 37500442)
10. Friis-Hansen L. Lessons from the gastrin knockout mice. Regul Pept 2007; 139: 5-22.
11. Langhans N, Rindi G, Chiu M, Rehfeld JF, Ardman B, Beinborn M, et al. Abnormal gastric histology and decreased acid production in cholecystokinin-B/ gastrin receptor-deficient mice. Gastroenterology 1997; 112: 280-286. (Pubitemid 27009012)
12. Chen D, Zhao CM, Al-Haider W, Håkanson R, Rehfeld JF, Kopin AS. Differentiation of gastric ECL cells is altered in CCK(2) receptor-deficient mice. Gastroenterology 2002; 123: 577-585.
13. Tanaka S, Hamada K, Yamada N, Sugita Y, Tonai S, Hunyady B, et al. Gastric acid secretion in L-histidine decarboxylase-deficient mice. Gastroenterology 2002; 122: 145-155. (Pubitemid 34049203)
14. Chen D, Zhao CM, Håkanson R, Samuelson LC, Rehfeld JF, Friis-Hansen L. Altered control of gastric acid secretion in gastrincholecystokinin double mutant mice. Gastroenterology 2004; 126: 476-487. (Pubitemid 38182305)
15. Martinez V, Curi AP, Torkian B, Schaeffer JM, Wilkinson HA, Walsh JH, et al. High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice. Gastroenterology 1998; 114: 1125-1132. (Pubitemid 28243897)
16. Zhao CM, Martinez V, Piqueras L, Wang L, Taché Y, Chen D. Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathways. Endocrinology 2008; 149: 498-505. (Pubitemid 351159345)
17. Lindström E, Björkqvist M, Boketoft A, Chen D, Zhao CM, Kimura K, et al. Neurohormonal regulation of histamine and pancreastatin secretion from isolated rat stomach ECL cells. Regul Pept 1997; 71: 73-86. (Pubitemid 27504873)
18. Zeng N, Kang T, Wen Y, Wong H, Walsh J, Sachs G. Galanin inhibition of enterochromaffin-like cell function. Gastroenterology 1998; 115: 330-339. (Pubitemid 28363425)
19. Kopin AS, Lee YM, McBride EW, Miller LJ, Lu M, Lin HY, et al. Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc Natl Acad Sci USA 1992; 89: 3605-3609.
20. Schmitz F, Goke MN, Otte JM, Schrader H, Reimann B, Kruse ML, et al. Cellular expression of CCK-A and CCK-B/gastrin receptors in human gastric mucosa. Regul Pept 2001; 102: 101-110. (Pubitemid 33135571)
21. Tømmerås K, Bakke I, Sandvik AK, Larsson E, Waldum HL. Rat parietal cells express CCK(2) receptor mRNA: gene expression analysis of single cells isolated by laser-assisted microdissection. Biochem Biophys Res Commun 2002; 297: 335-340.
22. Cabero JL, Li ZQ, Mardh S. Gastrin potentiates histamine-stimulated aminopyrine accumulation in isolated rat parietal cells. Am J Physiol 1991; 261: G621-7.
23. Cabero JL, Li ZQ, Mardh S. Gastrin action on aminopyrine accumulation in isolated pig parietal cells requires cAMP. Biochim Biophys Acta 1993; 1177: 245-252.
24. Athmann C, Zeng N, Scott DR, Sachs G. Regulation of parietal cell calcium signaling in gastric glands. Am J Physiol 2000; 279: G1048-58.
25. Wank SA. Cholecystokinin receptors. Am J Physiol 1995; 269: G628-46.
26. Wank SA. G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family. Am J Physiol 1998; 274: G607-13.
27. Lindström E, Håkanson R. Neurohormonal regulation of secretion from isolated rat stomach ECL cells: a critical reappraisal. Regul Pept 2001; 97: 169-180.
28. Chiba T, Fisher SK, Agranoff BW, Yamada T. Autoregulation of muscarinic and gastrin receptors on gastric parietal cells. Am J Physiol 1989; 256: G356-63.
29. Piqueras L, Taché Y, Martinez V. Somatostatin receptor type 2 mediates bombesin-induced inhibition of gastric acid secretion in mice. J Physiol 2003; 549: 889-901.
30. Hill SJ. Histamine receptors and interactions between second messenger transduction systems. Agents Actions Suppl 1991; 33: 145-159.
31. 2 receptors heterologously expressed in adult rat atrial myocytes. Biochim Biophys Acta 2003; 1642: 67-77.
32. Wang TC, Koh TJ, Varro A, Cahill RJ, Dangler CA, Fox JG, et al. Processing and proliferative effects of human progastrin in transgenic mice. J Clin Invest 1996; 98: 1918-1929. (Pubitemid 26359210)
33. Koh TJ, Dockray GJ, Varro A, Cahill RJ, Dangler CA, Fox JG, et al. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J Clin Invest 1999; 103: 1119-1126. (Pubitemid 29207245)
34. Palnæs Hansen C, Stadil F, Rehfeld JF. Metabolism and influence of glycine-extended gastrin on gastric acid serection in man. Digestion 1996; 57: 22-29. (Pubitemid 26002875)
35. Matsumoto M, Park J, Sugano K, Yamada T. Biological activity of progastrin posttranslational processing intermediates. Am J Physiol 1987; 252: G315-9. (Pubitemid 17066318)
36. Dickinson CJ, Marino L, Yamada T. Inhibition of the α-amidation of gastrin: effects on gastric acid secretion. Am J Physiol 1990; 258: G810-14.
37. Higashide S, Gomez G, Greeley GH, Townsend CM, Thompson JC. Glycine-extended gastrin potentiates gastrin-stimulated gastric acid secretion in rats. Am J Physiol 1996; 270: G220-4.
38. Chen D, Zhao CM, Dockray GJ, Varro A, Van Hoek A, Sinclair NF, et al. Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice. Gastroenterology 2000; 119: 756-765.
39. Chen D, Stenström B, Zhao CM, Wadström T. Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer? Inadequate evidence in Mongolian gerbils and inbred mice. FEMS Immunol Med Microbiol 2007; 50: 184-189.
40. Wang TC, Dangler CA, Chen D, Goldenring JR, Koh T, Raychowdhury R, et al. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology 2000; 118: 36-47.
41. Fox JG, Wang TC, Rogers AB, Poutahidis T, Ge Z, Taylor N, et al. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology 2003; 124: 1879-1890.
42. Takaishi S, Cui G, Frederick DM, Carlson JE, Houghton J, Varro A, et al. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Gastroenterology 2005; 128: 1965-1983.
43. Stenström B, Zhao CM, Rogers AB, Nilsson HO, Sturegård E, Lundgren S, et al. Swedish moist snuff accelerates gastric cancer development in Helicobacter pylori-infected wild-type and gastrin transgenic mice. Carcinogenesis 2007; 28: 2041-2046. (Pubitemid 47500621)
44. Zhao CM, Wang X, Friis-Hansen L, Waldum HL, Halgunset J, Wadstrom T, et al. Chronic Helicobacter pylori infection results in gastric hypoacidity and hypergastrinemia in wild-type mice but vagally induced hypersecretion in gastrin-deficient mice. Regul Pept 2003; 115: 161-170. (Pubitemid 37211431)
45. Woodward ER. The history of vagotomy. Am J Surg 1987; 153: 9-17.
46. Johnson AG. Proximal gastric vagotomy: does it have a place in the future management of peptic ulcer? World J Surg 2000; 24: 259-263.
47. Ansquer C, Kraeber-Bodere F, Chatal JF. Current status and perspectives in peptide receptor radiation therapy. Curr Pharm Des 2009; 15(21): 2453-2462.
48. Evangelista S. Role of calcitonin gene-related Peptide in gastric mucosal defence and healing. Curr Pharm Des 2009; 15(30): 3571-3576.
49. Zwanziger D, Beck-Sickinger AG. Radiometal targeted tumor diagnosis and therapy with peptide hormones. Curr Pharm Des 2008; 14(24): 2385-2400.