Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy

Archives of Neurology

Volumn 67, Issue 4, 2010, Pages 408-415

  Arif, Hiba ^a   Buchsbaum, Richard ^b   Pierro, Joanna ^a   Whalen, Michael ^a   Sims, Jessica ^a   Resor Jr , Stanley R ^a   Bazil, Carl W ^a   Hirsch, Lawrence J ^a  

^a NEUROLOGICAL INSTITUTE   (United States)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOBAZAM; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENYTOIN; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

ADULT; AGED; ARTICLE; BALANCE DISORDER; COGNITIVE DEFECT; CONTROLLED STUDY; DIZZINESS; DROWSINESS; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG INDUCED HEADACHE; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL SYMPTOM; GENERALIZED EPILEPSY; HAIR LOSS; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SIDE EFFECT; SLEEP DISORDER; TREMOR; VISUAL DISORDER; WEIGHT GAIN;

ADULT; AGED; AMINES; ANTICONVULSANTS; CARBAMAZEPINE; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; EPILEPSY; FEMALE; FRUCTOSE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; PHENYTOIN; PIRACETAM; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; TRIAZINES;

EID: 77950870915     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2010.49     Document Type: Article

References (19)

1. de la Court A, Breteler MM, Meinardi H, Hauser WA, Hofman A. Prevalence of epilepsy in the elderly: the Rotterdam Study. Epilepsia. 1996;37(2):141-147. (Pubitemid 26043792)
2. Hauser WA. Seizure disorders: the changes with age. Epilepsia. 1992;33(suppl 4):S6-S14.
3. Sander JW, Shorvon SD. Epidemiology of the epilepsies. J Neurol Neurosurg Psychiatry. 1996;61(5):433-443.
4. Brodie MJ, Overstall PW, Giorgi L; the UK Lamotrigine Elderly Study Group. Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. Epilepsy Res. 1999;37(1):81-87.
5. Rowan AJ, Ramsay RE, Collins JF, et al; VA Cooperative Study 428 Group. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology. 2005;64(11):1868-1873.
6. Saetre E, Perucca E, Isojarvi J, Gjerstad L; LAM 40089 Study Group. An international multicenter randomized double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy in the elderly. Epilepsia. 2007;48(7):1292-1302. (Pubitemid 47063092)
7. O'Mahony MS, Woodhouse KW. Age, environmental factors and drug metabolism. Pharmacol Ther. 1994;61(1-2):279-287. (Pubitemid 24210643)
8. Ramsay RE, Shields WD, Shinnar S. Special issues in the management of young children, older adults, and the developmentally disabled. J Child Neurol. 2007;22(5)(suppl):53S-60S. (Pubitemid 46939000)
9. Willmore LJ. Antiepileptic drug therapy in the elderly. Pharmacol Ther. 1998;78(1):9-16.
10. Aulakh JS, Hawkins JW, Athwal HS, Sheikh JI, Yesavage J, Tinklenberg JR. Tolerability and effectiveness of lamotrigine in complex elderly patients. J Geriatr Psychiatry Neurol. 2005;18(1):8-11. (Pubitemid 40313185)
11. Mauri Llerda JA, Tejero C, Mercade JM, Padro LL, Salas Puig J. Lamotrigine and epilepsy in the elderly: observational study of low-dose monotherapy. Int J Clin Pract. 2005;59(6):651-654. (Pubitemid 44192634)
12. Giorgi L, Gomez G, O'Neill F, Hammer AE, Risner M. The tolerability of lamotrigine in elderly patients with epilepsy. Drugs Aging. 2001;18(8):621-630. (Pubitemid 32803540)
13. Canger R, Altamura AC, Belvedere O, et al. Conventional vs controlled-release carbamazepine: a multicentre, double-blind, cross-over study. Acta Neurol Scand. 1990;82(1):9-13. (Pubitemid 20249244)
14. Eeg-Olofsson O, Nilsson HL, Tonnby B, et al. Diurnal variation of carbamazepine and carbamazepine-10,11-epoxide in plasma and saliva in children with epilepsy: a comparison between conventional and slow-release formulations. J Child Neurol. 1990;5(2):159-165. (Pubitemid 20213448)
15. Kinirons P, McCarthy M, Doherty CP, Delanty N. Predicting drug-resistant patients who respond to add-on therapy with levetiracetam. Seizure. 2006;15(6):387-392. (Pubitemid 44184811)
16. Peltola J, Peltola M, Auvinen A, et al. Clinical predictors in patients with refractory epilepsy exposed to levetiracetam: a single-center study. Acta Neurol Scand. 2008;117(5):332-336. (Pubitemid 351503332)
17. Brodie MJ, Yuen AW. Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. Epilepsy Res. 1997;26(3):423-432.
18. Brodie MJ, Stephen LJ. Outcomes in elderly patients with newly diagnosed and treated epilepsy. Int Rev Neurobiol. 2007;81:253-263.
19. Stephen LJ, Kelly K, Mohanraj R, Brodie MJ. Pharmacological outcomes in older people with newly diagnosed epilepsy. Epilepsy Behav. 2006;8(2):434-437. (Pubitemid 43231238)