Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2299-2306

  Sun, Min ^a   Wu, Xiaoqing ^a,b   Chen, Junqing ^a   Cai, Jin ^a   Cao, Meng ^a   Ji, Min ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

A549; Antitumor activity; Diaryl ureas; MDA MB 231

Indexed keywords

1 (4 CHLORO 3 NITROPHENYL) 3 [4 [4 (THIAZOL 2 YL)PHENOXY]PHENYL]UREA; 1 [3 BROMO 5 (TRIFLUOROMETHYL)PHENYL] 3 [4 [4 (THIAZOL 2 YL)PHENOXY]PHENYL]UREA; 1 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 3 [4 [4 (THIAZOL 2 YL)PHENOXY]PHENYL]UREA; 1 [4 FLUORO 3 (TRIFLUOROMETHYL)PHENYL] 3 [4 [4 (THIAZOL 2 YL)PHENOXY]PHENYL]UREA; SORAFENIB; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROMETRY; LUNG NON SMALL CELL CANCER; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; SPECTRUM ANALYSIS; UREA;

EID: 77950867133     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.005     Document Type: Article

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