Liquid chromatography-tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC 743400 and NSC 725776

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 5, 2010, Pages 714-720

  Holleran, Julianne L ^a   Parise, Robert A ^a   Yellow Duke, Archibong E ^a   Egorin, Merrill J ^a,b   Eiseman, Julie L ^a,b   Covey, Joseph M ^c   Beumer, Jan H ^a,d  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Assay; Indenoisoquinolines; Tandem mass spectrometry; Topoisomerase; Validation

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETONITRILE; FORMIC ACID; INDENOISOQUINOLINE ISOMERASE INHIBITOR; ISOMERASE INHIBITOR; NSC 725776; NSC 743400; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CALIBRATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FOOD AND DRUG ADMINISTRATION; HUMAN; LIQUID CHROMATOGRAPHY; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROTEIN BINDING; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY;

BENZODIOXOLES; CALIBRATION; CHROMATOGRAPHY, LIQUID; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HUMANS; ISOQUINOLINES; LIMIT OF DETECTION; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 77950863813     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.02.020     Document Type: Article

References (7)

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