Patient preference and acceptability of calcium plus vitamin D3 supplementation: A randomised, open, cross-over trial

Clinical Rheumatology

Volumn 29, Issue 5, 2010, Pages 465-472

  Den Uyl, Debby ^a   Geusens, Piet P M M ^b   Van Berkum, Frank N R ^c   Houben, Harry H M L ^d   Jebbink, Max C ^e   Lems, Willem F ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c Atrium Medical Centre ^*  (Netherlands)

^d Zuyderland Medical Centre   (Netherlands)

^e REINIER DE GRAAF HOSPITAL   (Netherlands)

Author keywords

Calcium; Drug preference; Osteoporosis; Treatment adherence; Vitamin D

Indexed keywords

CALCI CHEW D3; CALCIUM CARBONATE; CALCIUM CARBONATE PLUS COLECALCIFEROL; COLECALCIFEROL; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; AGED; APHTHOUS STOMATITIS; ARTICLE; CHEWABLE TABLET; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DOSE RESPONSE; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG PREFERENCE; DRUG TOLERABILITY; DRUG USE; DRUG WITHDRAWAL; DYSPEPSIA; ERUCTATION; EVENING DOSAGE; FEMALE; FLATULENCE; GASTROINTESTINAL DISEASE; HEADACHE; HUMAN; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; MULTICENTER STUDY; NAUSEA; NEUROLOGIC DISEASE; OSTEOPOROSIS; PATIENT ASSESSMENT; PATIENT ATTITUDE; PATIENT COMPLIANCE; PRIORITY JOURNAL; PRURITUS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SKIN DISEASE; STOMACH DISCOMFORT; STOMACH HEMORRHAGE; TREATMENT OUTCOME; UROGENITAL TRACT DISEASE; VITAMIN SUPPLEMENTATION;

ADULT; AGED; AGED, 80 AND OVER; CALCIUM; CHOLECALCIFEROL; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, STATISTICAL; OSTEOPOROSIS; PATIENT PREFERENCE; QUESTIONNAIRES;

EID: 77950863512     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-009-1328-3     Document Type: Article

References (36)

1. CH Turner 2002 Biomechanics of bone: determinants of skeletal fragility and bone quality Osteoporos Int 13 97 104 10.1007/s001980200000 1:STN:280:DC%2BD387ntlaguw%3D%3D 11905527 (Pubitemid 34241029)
2. DA Doherty KM Sanders MA Kotowicz RL Prince 2001 Lifetime and five-year age-specific risks of first and subsequent osteoporotic fractures in postmenopausal women Osteoporos Int 12 16 23 10.1007/s001980170152 1:STN:280:DC%2BD3M3ivFKhtg%3D%3D 11305078 (Pubitemid 32233654)
3. WS Browner AR Pressman MC Nevitt SR Cummings 1996 Mortality following fractures in older women. The study of osteoporotic fractures Arch Intern Med 156 1521 1525 10.1001/archinte.156.14.1521 1:STN:280:DyaK283ptFahug%3D%3D 8687260 (Pubitemid 26244436)
4. C Cooper EJ Atkinson SJ Jacobsen WM O'Fallon LJ Melton III 1993 Population-based study of survival after osteoporotic fractures Am J Epidemiol 137 1001 1005 1:STN:280:DyaK3szgsVeltw%3D%3D 8317445 (Pubitemid 23191067)
5. C Cooper 1997 The crippling consequences of fractures and their impact on quality of life Am J Med 103 12S 17S 10.1016/S0002-9343(97)90022-X 1:STN:280:DyaK2svkvVGltQ%3D%3D 9302893 (Pubitemid 27386437)
6. RE Johnson MJ Goodman MC Hornbrook MB Eldredge 1997 The impact of increasing patient prescription drug cost sharing on therapeutic classes of drugs received and on the health status of elderly HMO members Health Serv Res 32 103 122 1:STN:280:DyaK2s3mt1GhsQ%3D%3D 9108807
7. MF Holick 2007 Vitamin D deficiency N Engl J Med 357 266 281 10.1056/NEJMra070553 1:CAS:528:DC%2BD2sXotVejsbc%3D 17634462 (Pubitemid 47080391)
8. KE Ensrud T Duong JA Cauley RP Heaney RL Wolf E Harris SR Cummings 2000 Low fractional calcium absorption increases the risk for hip fracture in women with low calcium intake study of osteoporotic fractures research group Ann Intern Med 132 345 353 1:STN:280:DC%2BD3c7ktlSmtA%3D%3D 10691584
9. RR Recker S Hinders KM Davies RP Heaney MR Stegman JM Lappe BD Kimmel 1996 Correcting calcium nutritional deficiency prevents spine fractures in elderly women J Bone Miner Res 11 1961 1966 10.1002/jbmr.5650111218 1:CAS:528:DyaK2sXjtVCluw%3D%3D 8970899 (Pubitemid 26425690)
10. BL Riggs LJ Melton III WM O'Fallon 1996 Drug therapy for vertebral fractures in osteoporosis: evidence that decreases in bone turnover and increases in bone mass both determine antifracture efficacy Bone 18 3 Suppl 197S 201S 10.1016/8756-3282(95)00502-1 1:CAS:528:DyaK28XislKjtLY%3D 8777088 (Pubitemid 126352531)
11. B Dawson-Hughes SS Harris EA Krall GE Dallal 1997 Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older N Engl J Med 337 670 676 10.1056/NEJM199709043371003 1:CAS:528: DyaK2sXmt1Wqtbk%3D 9278463 (Pubitemid 27375473)
12. MC Chapuy ME Arlot F Duboeuf J Brun B Crouzet S Arnaud PD Delmas PJ Meunier 1992 Vitamin D3 and calcium to prevent hip fractures in the elderly women N Engl J Med 327 1637 1642 1:STN:280:DyaK3s%2FmtlSrug%3D%3D 1331788
13. MC Chapuy R Pamphile E Paris C Kempf M Schlichting S Arnaud P Garnero PJ Meunier 2002 Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study Osteoporos Int 13 257 264 10.1007/s001980200023 1:CAS:528:DC%2BD38XksVynt7g%3D 11991447 (Pubitemid 34408194)
14. RD Jackson AZ LaCroix M Gass RB Wallace J Robbins CE Lewis T Bassford SAA Beresford HR Black P Blanchette DE Bonds RL Brunner RG Bryski B Caan JA Cauley RT Cheblowski SR Cummings I Granek J Hays G Heiss SL Hendrix BV Howard J Hsia FA Hubbell KC Johnson H Judd JM Kotchen LH Kuller RD Langer NL Lasser MC Limacher S Ludlam JE Manson KL Margolis J McGowan JK Ockene MJ O'Sullivan L Phillips RL Prentice GE Sarto ML Stefanick L Van Horn J Wactawski-Wende E Whitlock GL Anderson AR Assaf D Barad 2006 Calcium plus vitamin D supplementation and the risk of fractures N Engl J Med 354 669 683 10.1056/NEJMoa055218 1:CAS:528:DC%2BD28XhsVWksr0%3D 16481635 (Pubitemid 43247138)
15. P Lips WC Graafmans ME Ooms PD Bezemer LM Bouter 1996 Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial Ann Intern Med 124 400 406 1:STN:280:DyaK287ltF2nsQ%3D%3D 8554248 (Pubitemid 26065071)
16. DM Black SR Cummings DB Karpf JA Cauley DE Thompson MC Nevitt DC Bauer HK Genant WL Haskell R Marcus SM Ott JC Torner SA Quandt TF Reiss KE Ensrud 1996 Fracture intervention trial research group: randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures Lancet 348 1535 1541 10.1016/S0140-6736(96)07088-2 1:CAS:528: DyaK2sXisFCktQ%3D%3D 8950879 (Pubitemid 26411651)
17. PD Delmas RR Recker CH Chesnut III A Skag JA Stakkestad R Emkey J Glibride RC Schimmer C Christiansen 2004 Daily and intermittent oral ibandronate normalize bone turnover and provide significant reduction in vertebral fracture risk: results from the BONE study Osteoporos Int 15 792 798 10.1007/s00198-004-1602-9 1:CAS:528:DC%2BD2cXnsVCit7g%3D 15071723 (Pubitemid 39361949)
18. JW Nieves L Komar F Cosman R Lindsay 1998 Calcium potentiates the effect of estrogen and calcitonin on bone mass: review and analysis Am J Clin Nutr 67 18 24 1:CAS:528:DyaK1cXjvFenuw%3D%3D 9440370 (Pubitemid 28037620)
19. T Tanvetyanon PJ Stiff 2006 Management of the adverse effects associated with intravenous bisphosphonates Ann Oncol 17 897 907 10.1093/annonc/mdj105 1:STN:280:DC%2BD283nslensA%3D%3D 16547070 (Pubitemid 43785797)
20. F Lekkerkerker JA Kanis N Alsayed G Bouvenot N Burlet D Cahall A Chines P Delmas RL Dreiser D Ethgen N Hughes JM Kaufman S Korte G Kreutz A Laslop B Mitlak V Rabenda R Rizzoli A Santora R Schimmer Y Tsouderos JY Reginster 2007 Adherence to treatment of osteoporosis: a need for a study Osteoporos Int 18 1311 1317 10.1007/s00198-007-0410-4 1:STN:280:DC%2BD2srjtVensw%3D%3D 17585359 (Pubitemid 47389473)
21. JE Compston E Seeman 2006 Compliance with osteoporosis therapy is the weakest link Lancet 368 973 974 10.1016/S0140-6736(06)69394-X 16980096 (Pubitemid 44353676)
22. B Cortet O Benichou 2006 Adherence, persistence, concordance: do we provide optimal management to our patients with osteoporosis? Joint Bone Spine 73 e1 e7 10.1016/j.jbspin.2006.02.006 16949324 (Pubitemid 44848053)
23. JS McCombs P Thiebaud C Laughlin-Miley J Shi 2004 Compliance with drug therapies for the treatment and prevention of osteoporosis Maturitas 48 271 287 10.1016/j.maturitas.2004.02.005 1:CAS:528:DC%2BD2cXltVCiu7g%3D 15207894 (Pubitemid 38781153)
24. M Rossini G Bianchi MO Di S Giannini S Minisola L Sinigaglia S Adami 2006 Determinants of adherence to osteoporosis treatment in clinical practice Osteoporos Int 17 914 921 10.1007/s00198-006-0073-6 1:STN:280: DC%2BD283osVKltg%3D%3D 16538553 (Pubitemid 43781506)
25. ES Siris PL Selby KG Saag F Borgström RMC Herings SL Silverman 2009 Impact of osteoporosis treatment adherence on fracture rates in North America and Europe Am J Med 122 S3 S13 10.1016/j.amjmed.2008.12.002 19187810
26. CH van den Boogaard NS Breekveldt-Postma SE Borggreve WG Goettsch RM Herings 2006 Persistent bisphosphonate use and the risk of osteoporotic fractures in clinical practice: a database analysis study Curr Med Res Opin 22 1757 1764 10.1185/030079906X132370 16968579 (Pubitemid 44449232)
27. T Nikolaus W Kruse M Bach N Specht-Leible P Oster G Schlierf 1996 Elderly patients' problems with medication. An in-hospital and follow-up study Eur J Clin Pharmacol 49 255 259 10.1007/BF00226324 1:STN:280:DyaK2s%2FhtVSjug%3D%3D 8857069 (Pubitemid 126425472)
28. TP Rees I Howe 2001 A randomised, single-blind, crossover comparison of the acceptability of the calcium and vitamin D3 supplements Calcichew D3 Forte and Ad Cal D3 in elderly patients Curr Med Res Opin 16 245 251 10.1185/030079901750120178 1:CAS:528:DC%2BD3MXisV2itbs%3D 11268708 (Pubitemid 32221481)
29. YR Reginster JM Kaufman V Gangjii 2005 Preference for and acceptability of two formulations of a dietary containing calcium plus vitamin D3: a randomised, open-label, crossover trial in adult patients with calcium and vitamin D deficiencies Curr Therap Res 66 23 34 10.1016/j.curtheres.2005.03.003 1:CAS:528:DC%2BD2MXjvFOrt78%3D (Pubitemid 41115334)
30. B Dawson-Hughes SS Harris EA Krall GE Dallal 2000 Effect of withdrawal of calcium and vitamin D supplements on bone mass in elderly men and women Am J Clin Nutr 72 745 750 1:CAS:528:DC%2BD3cXmsFGrtr0%3D 10966893
31. AM Grant A Avenell MK Campbell C Cooper C Donaldson RM Francis WJ Gillespie CM Robinson DJ Torgerson WA Wallace GC McPherson GS MacLennan AM McDonald 2005 Oral Vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised controlled trial Lancet 365 1621 1628 10.1016/S0140- 6736(05)63013-9 1:STN:280:DC%2BD2M3kslClsA%3D%3D 15885294 (Pubitemid 40693411)
32. C Salzman 1995 Medication compliance in the elderly J Clin Psychiatry 56 Suppl 1 18 22 7836347
33. R Keen E Jodar G Iolascon HP Kruse A Varbanov B Mann DT Gold 2006 European women's preference for osteoporosis treatment: influence of clinical effectiveness and dosing frequency Curr Med Res Opin 22 2375 2381 10.1185/030079906X154079 17257451 (Pubitemid 46055200)
34. AN Tosteson MR Grove CS Hammond MM Moncur GT Ray GM Hebert AR Pressman B Ettinger 2003 Early discontinuation of treatment for osteoporosis Am J Med 115 209 216 10.1016/S0002-9343(03)00362-0 12947959 (Pubitemid 37338146)
35. N Zafran Z Liss R Peled M Sherf H Reuveni 2005 Incidence and causes for failure of treatment of women with proven osteoporosis Osteoporos Int 16 1375 1383 10.1007/s00198-005-1838-z 15806322 (Pubitemid 41532090)
36. JY Reginster V Rabenda A Neuprez 2006 Adherence, patient preference and dosing frequency: understanding the relationship Bone 38 4 Suppl 1 S2 S6 10.1016/j.bone.2006.01.150 1:STN:280:DC%2BD287mvFOitA%3D%3D 16520104