Potential involvement of the stem cell factor receptor c-kit in alopecia areata and androgenetic alopecia: Histopathological, immunohistochemical, and semiquantitative investigations

Acta Histochemica et Cytochemica

Volumn 43, Issue 1, 2010, Pages 9-17

  Ashrafuzzaman, M ^a,b   Yamamoto, Tomoko ^a   Shibata, Noriyuki ^a   Hirayama, Takeshi Thomas ^a   Kobayashi, Makio ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b DHAKA MEDICAL COLLEGE HOSPITAL   (Bangladesh)

Author keywords

Alopecia; C kit; Histopathology; Immunohistochemistry; Semiquantitation

Indexed keywords

EID: 77950849862     PISSN: 00445991     EISSN: 13475800     Source Type: Journal    
DOI: 10.1267/ahc.09032     Document Type: Article

References (33)

1. André, C., Martin, E., Cornu, F., Hu, W. X., Wang, X. P. and Galibert, F. (1992) Genomic organization of the human c-kit gene: evolution of the receptor tyrosine kinase subclass III. Oncogene 7; 685-691.
2. Bergfeld, W. F. (1992) Hair disorders. In "Dermatology", 3rd ed., ed. by L. S. Moschlla and J. H. Hurley, W. B. Saunders Company, Philadelphia, pp. 1541-1560.
3. Blechman, J. M., Lev, S., Brizzi, M. F., Leitner, O., Pegoraro, L., Givol, D. and Yarden, Y. (1993) Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor. J. Biol. Chem. 268; 4399-4406.
4. Botchkareva, N. V., Khlgatian, M., Longley, B. J., Botchkarev, V. A. and Gilchrest, B. A. (2001) SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit. FASEB. J. 15; 645-658.
5. Cetin, E. D., Savk, E., Uslu, M., Eskin, M. and Karul, A. (2009) Investigation of the inflammatory mechanisms in alopecia areata. Am. J. Dermatopathol. 31; 53-60.
6. Deberry, C., Mou, S. and Linnekin, D. (1997) Stat 1 associates with c-kit and is activated in response to stem cell factor. Biochem. J. 327; 73-80.
7. Edling, C. E. and Hallberg, B. (2007) c-Kit-a hematopoietic cell essential receptor tyrosine kinase. Int. J. Biochem. Cell Biol. 39; 1995-1998.
8. Gerdes, J., Lemke, H., Baisch, H., Wacker, H. H., Schwab, U. and Stein, H. (1984) Cell cycle analysis of a cell proliferationassociated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 133; 1710-1715.
9. Hillmer, A. M., Hanneken, S., Ritzmann, S., Becker, T., Freudenberg, J., Brockschmidt, F. F., Flaquer, A., Freudenberg-Hua, Y., Jamra, R. A., Metzen, C., Heyn, U., Schweiger, N., Betz, R. C., Blaumeiser, B., Hampe, J., Schreiber, S., Schulze, T. G., Hennies, H. C., Schumacher, J., Propping, P., Ruzicka, T., Cichon, S., Wienker, T. F., Kruse, R. and Nothen, M. M. (2005) Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am. J. Hum. Genet. 77; 140-148.
10. Hombach-Klonisch, S., Panigrahi, S., Rashedi, I., Seifert, A., Alberti, E., Pocar, P., Kurpisz, M., Schulze-Osthoff, K., Mackiewicz, A. and Los, M. (2008) Adult stem cells and their trans-differentiation potential-perspectives and therapeutic applications. J. Mol. Med. 86; 1301-1314.
11. Inaba, M. and Inaba, Y. (1996) Androgenetic Alopecia: Modern Concepts of Pathogenesis and Treatment, Springer-Verlag, Tokyo.
12. Kato, K., Hasui, K., Wang, J., Kawano, Y., Aikou, T. and Murata, F. (2008) Homeostatic mass control in gastric non-neoplastic epithelia under infection of Helicobacter pylori: an immunohistochemical analysis of cell growth, stem cells and programmed cell death. Acta Histochem. Cytochem. 41; 23-38.
13. Kawamoto, A. and Asahara, T. (2007) Role of progenitor endothelial cells in cardiovascular disease and upcoming therapies. Catheter Cardiovasc. Interv. 70; 477-484.
14. Kos, L. and Conlon, J. (2009) An update on alopecia areata. Curr. Opin. Pediatr. 21; 475-480.
15. Lavker, R. M., Bertolino, A. P., Freedberg, I. M. and Sun, T.-T. (1999) Biology of hair follicle. In "Fitzpatrick's Dermatology in General Medicine", 5th ed., ed. by I. M. Freedberg, Z. A. Eisen, K. Wolff, F. K. Austen, A. L. Goldsmith, I. S. Katz and B. T. Fitzpatrick, McGraw-Hill, New York, pp. 230-238.
16. Lazennec, G. and Jorgensen, C. (2008) Concise review: adult multipotent stromal cells and cancer: risk or benefit? Stem Cells 26; 1387-1394.
17. Lev, S., Yarden, Y. and Givol, D. (1992) A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCFstimulated cellular responses. J. Biol. Chem. 267; 10866-10873.
18. Miyauchi, S., Hashimoto, K. and Miki, Y. (1990) The innermost cell layer of the outer root sheath is positive with Ki-67. J. Invest.
19. More, K. A. and Lemischka, I. R. (2006) Stem cells and their niches. Science 311; 1880-1885.
20. Murphy, G. F. (1997) Histology of the skin. In "Lever's Histopathology of the Skin" 8th ed., ed. by D. Elder, R. Elenitsas, C. Jaworsky and B. Johnson Jr., Lippincott-Raven, Philadelphia, pp. 5-50.
21. Nishikawa, S., Kusakabe, M., Yoshinaga, K., Ogawa, M., Hayashi, S., Kunisada, T., Era, T., Sakakura, T. and Nishikawa, S. (1991) In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit dependency during melanocyte development. EMBO. J. 10; 2111-2118.
22. Ohyama, M. (2007) Hair follicle bulge: a fascinating reservoir of epithelial stem cells. J. Dermatol. Sci. 46; 81-89.
23. Olsen, E. A. (1999) Hair disorders. In "Fitzpatrick's Dermatology in General Medicine", 5th ed., ed. by I. M. Freedberg, Z. A. Eisen, K. Wolff, F. K. Austen, A. L. Goldsmith, I. S. Katz and B. T. Fitzpatrick, McGraw-Hill, New York, pp. 751-751.
24. Paus, R. and Cotsarelis, G. (1999) The biology of hair follicles. New Engl. J. Med. 341; 491-497.
25. Peters, E. M., Maurer, M., Botchkarev, V. A., deMasey Jensen, K., Welker, P., Scott, Z. A. and Paus, R. (2003) Kit is expressed by epithelial cells in vivo. J. Invest. Dermatol. 121; 976-984.
26. Peters, E. M., Tobin, D. J., Botchkareva, N., Maurer, M. and Paus, R. (2002) Migration of melanoblasts into the developing murine hair follicle is accompanied by transient c-kit expression. J. Histochem. Cytochem. 50; 751-766.
27. Randall, V. A. (2008) Androgens and hair growth. Dermatol. Ther. 21; 314-328.
28. Randall, V. A., Jenner, T. J., Hibberts, N. A., De Oliveira, I. O. and Vafaee, T. (2008) Stem cell factor/c-kit signaling in normal and androgenetic alopecia hair follicles. J. Endocrinol. 197; 11-23.
29. Schneider, M. R., Schmidt-Ullrich, R. and Paus, R. (2009) The hair follicle as a dynamic miniorgan. Curr. Biol. 19; R132-R142.
30. Scholzen, T. and Gerdes, J. (2000) The Ki-67 protein: from the known and the unknown. J. Cell. Physiol. 182; 311-322.
31. Tang, B., Mano, H., Yi, T. and Ihle, J. N. (1994) The kinase associates with c-kit and its tyrosine phosphorylated and activated following stem cell factor binding. Mol. Cell. Biol. 14; 8432-8437.
32. Tobin, D. J. and Paus, R. (2001) Graying: gerontobiology of the hair follicle pigmentary unit. Exp. Gerontol. 36; 29-54.
33. van Baar, H. M., Perret, C. M., van Vlijmen, I. M., van de Kerkhof, P. C., Happle, R. and Schalkwijk, J. (1992) Abnormal expression of Ki-67 antigen in hair follicle of alopecia areata. Acta Derm. Venereol. 72; 161-164.