A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls

World Journal of Biological Psychiatry

Volumn 11, Issue 2 PART 2, 2010, Pages 431-438

  Hashimoto, Ryota ^a,b,c   Noguchi, Hiroko ^b   Hori, Hiroaki ^b   Nakabayashi, Tetsuo ^d   Suzuki, Tatsuyo ^e   Iwata, Nakao ^c,e   Ozaki, Norio ^c,f   Kosuga, Asako ^g   Tatsumi, Masahiko ^h   Kamijima, Kunitoshi ^g   Harada, Seiichi ^d   Takeda, Masatoshi ^a   Saitoh, Osamu ^d   Kunugi, Hiroshi ^b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^e FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g SHOWA UNIVERSITY   (Japan)

^h Yokohama Shinryo Clinic   (Japan)

Author keywords

DTNBP1; Dysbindin; Memory; Polymorphism; Schizophrenia

Indexed keywords

DYSBINDIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; VERBAL MEMORY; WECHSLER INTELLIGENCE SCALE; WECHSLER MEMORY SCALE;

ADULT; CARRIER PROTEINS; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MEMORY; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; WECHSLER SCALES;

EID: 77950841062     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622970902736503     Document Type: Article

References (42)

1. Benson MA, Newey SE, Martin-Rendon E, Hawkes R, Blake DJ. 2001. Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. J Biol Chem 276(26):24232-24241.
2. Blake DJ, Kroger S. 2000. The neurobiology of duchenne muscular dystrophy: learning lessons from muscle? Trends Neurosci 23(3):92-99.
3. Blake DJ, Weir A, Newey SE, Davies KE. 2002. Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol Rev 82(2):291-329.
4. Boyer P, Phillips JL, Rousseau FL, Ilivitsky S. 2007. Hippocampal abnormalities and memory deficits: new evidence of a strong pathophysiological link in schizophrenia. Brain Res Rev 54(1):92-112.
5. Braff DL, Freedman R, Schork NJ, Gottesman II. 2007. Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull 33(1):21-32.
6. Burdick KE, Lencz T, Funke B, Finn CT, Szeszko PR, Kane JM, et al. 2006. Genetic variation in DTNBP1 influences general cognitive ability. Hum Mol Genet 15(10):1563-1568. (Pubitemid 43904822)
7. Burdick KE, Goldberg TE, Funke B, Bates JA, Lencz T, Kucherlapati R, et al. 2007. DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophr Res 89(1-3): 169-172. (Pubitemid 44881303)
8. Chiba S, Hashimoto R, Hattori S, Yohda M, Lipska B, Weinberger DR, et al. 2006. Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus. J Neural Transm 113(9):1337-1346. (Pubitemid 44291026)
9. DeRosse P, Funke B, Burdick KE, Lencz T, Ekholm JM, Kane JM, et al. 2006. Dysbindin genotype and negative symptoms in schizophrenia. Am J Psychiatry 163(3):532-534. (Pubitemid 44469399)
10. Donohoe G, Morris DW, Clarke S, McGhee KA, Schwaiger S, Nangle JM, et al. 2007. Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: A preliminary study. Neuropsychologia 45(2):454-8. (Pubitemid 44828767)
11. Fanous AH, van den Oord EJ, Riley BP, Aggen SH, Neale MC, O'Neill FA, et al. 2005. Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia. Am J Psychiatry 162(10):1824-1832.
12. Funke B, Finn CT, Plocik AM, Lake S, DeRosse P, Kane JM, et al. 2004. Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet 75(5):891-898. (Pubitemid 39390497)
13. Good P. (2000). Permutation tests. A practical guide to resampling methods for testing hypothesis. New York: Springer-Verlag.
14. Harrison PJ, Weinberger DR. 2005. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10(1):40-68. (Pubitemid 40139588)
15. Hashimoto R, Hattori S, Chiba S, Yagasaki Y, Okada T, Kumamaru E, et al. 2006. Susceptibility genes for schizophrenia. Psychiatry Clin Neurosci 60 (Suppl 1):S4-10.
16. Hattori S, Murotani T, Matsuzaki S, Ishizuka T, Kumamoto N, Takeda M, et al. 2008. Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Biochem Biophys Res Commun 373(2):298-302.
17. Holliday EG, Handoko HY, James MR, McGrath JJ, Nertney DA, Tirupati S, et al. 2006. Association study of the dystrobrevinbinding gene with schizophrenia in Australian and Indian samples. Twin Res Hum Genet 9(4):531-539. (Pubitemid 46381683)
18. Iizuka Y, Sei Y, Weinberger DR, Straub RE. 2007. Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization. J Neurosci 27(45):12390-12395. (Pubitemid 350085456)
19. Joo EJ, Lee KY, Jeong SH, Ahn YM, Koo YJ, Kim YS. 2006. The dysbindin gene (DTNBP1) and schizophrenia: no support for an association in the Korean population. Neurosci Lett 407(2):101-106. (Pubitemid 44397234)
20. Kirov G, Ivanov D, Williams NM, Preece A, Nikolov I, Milev R, et al. 2004. Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. Biol Psychiatry 55(10):971-975. (Pubitemid 38581911)
21. Kumamoto N, Matsuzaki S, Inoue K, Hattori T, Shimizu S, Hashimoto R, et al. 2006. Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin. Biochem Biophys Res Commun 345(2):904-909. (Pubitemid 43776998)
22. Li T, Zhang F, Liu X, Sun X, Sham PC, Crombie C, et al. 2005. Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations. Mol Psychiatry 10(11):1037-1044. (Pubitemid 41541989)
23. Murotani T, Ishizuka T, Hattori S, Hashimoto R, Matsuzaki S, Yamatodani A. 2007. High dopamine turnover in the brains of Sandy mice. Neurosci Lett 421(1):47-51. (Pubitemid 46899330)
24. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, et al. 2004. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet 13(21):2699-2708. (Pubitemid 39485418)
25. Piskulic D, Olver JS, Norman TR, Maruff P. 2007. Behavioural studies of spatial working memory dysfunction in schizophrenia: a quantitative literature review. Psychiatry Res 150(2): 111-121. (Pubitemid 46389631)
26. Preston GA, Weinberger DR. 2005. Intermediate phenotypes in schizophrenia: a selective review. Dialogues Clin Neurosci 7(2):165-179. (Pubitemid 40961536)
27. Schwab SG, Knapp M, Mondabon S, Hallmayer J, Borrmann-Hassenbach M, Albus M, et al. 2003. Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am J Hum Genet 72(1):185-190. (Pubitemid 36056855)
28. Shinagawa F, Kobayashi S, Fujita K, Maekawa H. (1990). Japanese Wechsler Adult Intelligence Scale-Revised. Tokyo: Nihonbunkakagakusha.
29. Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV, et al. 2002. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet 71(2): 337-348.
30. Sugishita M. (2001). Japanese Wechsler Memory Scale-Revised. Tokyo: Nihonbunkakagakusha.
31. Takao K, Toyama K, Nakanishi K, Hattori S, Takamura H, Takeda M, et al. 2008. Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol Brain 1(1):11.
32. Talbot K, Eidem WL, Tinsley CL, Benson MA, Thompson EW, Smith RJ, et al. 2004. Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. J Clin Invest 113(9):1353-1363.
33. Tang JX, Zhou J, Fan JB, Li XW, Shi YY, Gu NF, et al. 2003. Family-based association study of DTNBP1 in 6p22.3 and schizophrenia. Mol Psychiatry 8(8):717-718.
34. Tochigi M, Zhang X, Ohashi J, Hibino H, Otowa T, Rogers M, et al. 2006. Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population. Neurosci Res 56(2):154-158.
35. Toulopoulouand T, Murray RM. 2004. Verbal memory deficit in patients with schizophrenia: an important future target for treatment. Expert Rev Neurother 4(1):43-52.
36. Van Den Bogaert A, Schumacher J, Schulze TG, Otte AC, Ohlraun S, Kovalenko S, et al. 2003. The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease. Am J Hum Genet 73(6):1438-1443.
37. van den Oord EJ, Sullivan PF, Jiang Y, Walsh D, O'Neill FA, Kendler KS, et al. 2003. Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families. Mol Psychiatry 8(5):499-510.
38. Wechsler D. (1981). Wechsler Adult Intelligence Scale, Revised. New York: Psychological Corporation.
39. Wechsler D. (1987). Wechsler Memory Scale Manual, Revised. San Antonio, TX: Psychological Corporation.
40. Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, et al. 2004. Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry 61(6):544-555.
41. Williams NM, Preece A, Morris DW, Spurlock G, Bray NJ, Stephens M, et al. 2004. Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Arch Gen Psychiatry 61(4):336-344.
42. Wobrock T, Ecker UK, Scherk H, Schneider-Axmann T, Falkai P, Gruber O. 2008. Cognitive impairment of executive function as a core symptom of schizophrenia.World J Biol Psychiatry:1-10.