I. Slow oscillations in vaginal blood flow: Alterations during sexual arousal in rodents and humans

Journal of Sexual Medicine

Volumn 7, Issue 3, 2010, Pages 1074-1087

  Allers, Kelly A ^a   Richards, Natalie ^a   Sultana, Stefan ^a   Sudworth, Maria ^a   Dawkins, Toni ^a   Hawcock, Anthony B ^a   Buchanon, Tim ^b   Casey, James H ^a   Wayman, Chris ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Apomorphine; Laser doppler; Melanotan II; Partner preference; Photoplethysmography; Vaginal blood flow

Indexed keywords

APOMORPHINE; BREMELANOTIDE; INTERMEDIN DERIVATIVE; MELATONIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; FREQUENCY ANALYSIS; HUMAN; HUMAN EXPERIMENT; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; NORMAL HUMAN; OSCILLATION; PHOTOELECTRIC PLETHYSMOGRAPHY; PRIORITY JOURNAL; RODENT; SEXUAL AROUSAL; SEXUAL AROUSAL DISORDER; SEXUAL FUNCTION; VAGINA; VISUAL STIMULATION;

EID: 77950840714     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01465.x     Document Type: Article

References (19)

1. Rosen RC. Assessment of female sexual dysfunction: Review of validated methods. Fertil Steril 2002, 77(4):S89. suppl
2. Meston CM, McCall KM. Dopamine and norepinephrine responses to film-induced sexual arousal in sexually functional and sexually dysfunctional women. J Sex Marital Ther 2005, 31:303.
3. McMurray G, Casey JH, Naylor AM. Animal models in urological disease and sexual dysfunction. Br J Pharmacol 2006, 147(2):S62. suppl
4. Kamath MV, Fallen EL. Power spectral analysis of heart rate variability: A noninvasive signature of cardiac autonomic function. Crit Rev Biomed Eng 1993, 21:245.
5. Wilson TE, Zhang R, Levine BD, Crandall CG. Dynamic autoregulation of cutaneous circulation: Differential control in glabrous versus nonglabrous skin. Am J Physiol Heart Circ Physiol 2005, 289:H385.
6. Nakata A, Takata S, Yuasa T, Shimakura A, Maruyama M, Nagai H, Sakagami S, Kobayashi K. Spectral analysis of heart rate, arterial pressure, and muscle sympathetic nerve activity in normal humans. Am J Physiol 1998, 274:H1211.
7. Kvandal P, Landsverk SA, Bernjak A, Stefanovska A, Kvernmo HD, Kirkebøen KA. Low-frequency oscillations of the laser Doppler perfusion signal in human skin. Microvasc Res 2006, 72:120.
8. Bajrovic F, Cencur M, Hozic M, Ribaric S, Stefanovska A. The contribution of lumbar sympathetic neurones activity to rat's skin blood flow oscillations. Pflugers Arch 2000, 439:R158.
9. Stein PK, Kleiger RE. Insights from the study of heart rate variability. Annu Rev Med 1999, 50:249.
10. Yeragani VK, Pohl R, Balon R. Complex demodulation of cardiac interbeat intervals: Increased cardiac sympathovagal interaction during human sexual activity. Arch Sex Behav 2004, 33:65.
11. Caruso S, Agnello C, Intelisano G, Farina M, Di Mari L, Cianci A. Placebo-controlled study on efficacy and safety of daily apomorphine SL intake in premenopausal women affected by hypoactive sexual desire disorder and sexual arousal disorder. Urology 2004, 63:955.
12. Bechara A, Bertolino MV, Casabé A, Fredotovich N. A double-blind randomized placebo control study comparing the objective and subjective changes in female sexual response using sublingual apomorphine. J Sex Med 2004, 1:209.
13. Di Paolo T. Modulation of brain dopamine transmission by sex steroids. Rev Neurosci 1994, 5:27.
14. Drago F, Scapagnini U. Hormonal modulation of central dopaminergic transmission. J Neural Transm Suppl 1986, 22:47.
15. Rössler AS, Pfaus JG, Kia HK, Bernabé J, Alexandre L, Giuliano F. The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat. Pharmacol Biochem Behav 2006, 85:514.
16. Diamond LE, Earle DC, Heiman JR, Rosen RC, Perelman MA, Harning R. An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist. J Sex Med 2006, 3:628.
17. Beharry RK, Hale TM, Wilson EA, Heaton JP, Adams MA. Evidence for centrally initiated genital vasocongestive engorgement in the female rat: Findings from a new model of female sexual arousal response. Int J Impot Res 2003, 15:122.
18. Jänig W, Häbler HJ. Neurophysiological analysis of target-related sympathetic pathways-from animal to human: Similarities and differences. Acta Physiol Scand 2003, 177:255.
19. Hawcock T, Turner L, Dawkins T, Edmunds N. Effects of the dopamine receptor agonist, apomorphine on unconditioned sexual incentive motivation on ovariectomised female rats. J Sex Med 2007, 4(2):132. suppl