메뉴 건너뛰기




Volumn 5, Issue 1, 2010, Pages 93-96

Antineoplastic chemotherapy induced QTc prolongation

Author keywords

Antineoplastics; Chemotherapy; Cytostatic; HERG channel; QT interval prolongation; Torsades de pointes

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBOPLATIN; CREMOPHOR; CYCLOPHOSPHAMIDE; DASATINIB; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; FREE RADICAL; HISTONE DEACETYLASE INHIBITOR; IFOSFAMIDE; IMATINIB; LAPATINIB; NILOTINIB; OXAZAPHOSPHORINE DERIVATIVE; PACLITAXEL; PAZOPANIB; POTASSIUM CHANNEL HERG; PRAVASTATIN; PROTEIN TYROSINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; SORAFENIB; SUNITINIB; TRASTUZUMAB; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN;

EID: 77950815765     PISSN: 15748863     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488610789869111     Document Type: Review
Times cited : (71)

References (38)
  • 1
    • 33750848110 scopus 로고    scopus 로고
    • National Cancer Institute, version 3.0 DCTD, NCI, NIH, DHHS, Available from
    • National Cancer Institute: Cancer therapy evaluation program, Common terminology for adverse events, version 3.0 DCTD, NCI, NIH, DHHS, 2006. Available from: http://ctep.cancer.gov/forms/CTCAEv3.pdf.
    • (2006) Cancer Therapy Evaluation Program, Common Terminology for Adverse Events
  • 3
    • 33645317063 scopus 로고    scopus 로고
    • HERG potassium channels and cardiac arrhythmia
    • Sanguinetti MC, Tristani-Firouzi M. HERG potassium channels and cardiac arrhythmia. Nature 2006; 440 (7083): 463-469
    • (2006) Nature , vol.440 , Issue.7083 , pp. 463-469
    • Sanguinetti, M.C.1    Tristani-Firouzi, M.2
  • 4
    • 0036847942 scopus 로고    scopus 로고
    • Cardiac repolarization: Current knowledge, critical gaps, and new approaches to drug development and patient management
    • Anderson ME, Al-Khatib SA, Roden DM, Califf RM. Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management. Am Heart J 2002; 144: 769-781
    • (2002) Am Heart J , vol.144 , pp. 769-781
    • Anderson, M.E.1    Al-Khatib, S.A.2    Roden, D.M.3    Califf, R.M.4
  • 5
    • 33645087114 scopus 로고    scopus 로고
    • Safety biomarkers and the clinical development of oncology therapeutics: Considerations for cardiovascular safety and risk management
    • Fingert H, Varterasian M. Safety biomarkers and the clinical development of oncology therapeutics: considerations for cardiovascular safety and risk management. AAPS J 2006; 8(1): E89-94.
    • (2006) AAPS J , vol.8 , Issue.1
    • Fingert, H.1    Varterasian, M.2
  • 8
    • 40749093596 scopus 로고    scopus 로고
    • Anthracycline therapy can induce very early increase in QT dispersion and QTc prolongation
    • Pudil R, Horacek JM, Horackova J, Jebavy L, Vojacek J. Anthracycline therapy can induce very early increase in QT dispersion and QTc prolongation. Leuk Res 2008; 32(6): 998-999
    • (2008) Leuk Res , vol.32 , Issue.6 , pp. 998-999
    • Pudil, R.1    Horacek, J.M.2    Horackova, J.3    Jebavy, L.4    Vojacek, J.5
  • 9
    • 49449107089 scopus 로고    scopus 로고
    • New insight into epirubicin cardiac toxicity: Competing risks analysis of 1097 breast cancer patients
    • Ryberg M, Nielsen D, Cortese G, Nielsen G, Skovsgaard T, Andersen PK. New insight into epirubicin cardiac toxicity: competing risks analysis of 1097 breast cancer patients. J Natl Cancer Inst 2008; 100(15): 1058-1067
    • (2008) J Natl Cancer Inst , vol.100 , Issue.15 , pp. 1058-1067
    • Ryberg, M.1    Nielsen, D.2    Cortese, G.3    Nielsen, G.4    Skovsgaard, T.5    Andersen, P.K.6
  • 11
    • 29244472088 scopus 로고    scopus 로고
    • Effect of epirubicin-based chemotherapy and dexrazoxane supplementation on QT dispersion in non-Hodgkin lymphoma patients
    • Galetta F, Franzoni F, Cervetti G, et al. Effect of epirubicin-based chemotherapy and dexrazoxane supplementation on QT dispersion in non-Hodgkin lymphoma patients. Biomed Pharmacother 2005; 59(10): 541-544
    • (2005) Biomed Pharmacother , vol.59 , Issue.10 , pp. 541-544
    • Galetta, F.1    Franzoni, F.2    Cervetti, G.3
  • 12
    • 34548507964 scopus 로고    scopus 로고
    • The anthracycline-Trastuzumab interaction: Up-regulated binding may provide vital mechanistic insight
    • Ewer MS. The anthracycline-Trastuzumab interaction: up-regulated binding may provide vital mechanistic insight. Eur J Cancer 2007; 43(14): 2024-2025
    • (2007) Eur J Cancer , vol.43 , Issue.14 , pp. 2024-2025
    • Ewer, M.S.1
  • 13
    • 0033802643 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin (doxil): Reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2
    • Safra T, Muggia F, Jeffers S, et al. Pegylated liposomal doxorubicin (doxil): reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2. Ann Oncol 2000; 11: 1029-1033
    • (2000) Ann Oncol , vol.11 , pp. 1029-1033
    • Safra, T.1    Muggia, F.2    Jeffers, S.3
  • 14
    • 0032950467 scopus 로고    scopus 로고
    • Cardiotoxicity of the antiproliferative compound fluorouracil
    • Becker K, Erckenbrecht JF, Haussinger D. Frieling. Cardiotoxicity of the antiproliferative compound fluorouracil. Drugs 1999; 54: 475-484
    • (1999) Drugs , vol.54 , pp. 475-484
    • Becker, K.1    Erckenbrecht, J.F.2    Haussinger, D.F.3
  • 15
    • 66949158016 scopus 로고    scopus 로고
    • Fluoropyrimidine-associated cardiotoxicity: Revisited
    • Saif MW, Shah MM, Shah AR. Fluoropyrimidine-associated cardiotoxicity: revisited. Expert Opin Drug Saf 2009; 8(2): 191-202.
    • (2009) Expert Opin Drug Saf , vol.8 , Issue.2 , pp. 191-202
    • Saif, M.W.1    Shah, M.M.2    Shah, A.R.3
  • 16
    • 46549083150 scopus 로고    scopus 로고
    • Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis
    • Cheng CF, Juan SH, Chen JJ, et al. Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis. Apoptosis 2008; 13(7): 883-894
    • (2008) Apoptosis , vol.13 , Issue.7 , pp. 883-894
    • Cheng, C.F.1    Juan, S.H.2    Chen, J.J.3
  • 17
    • 0030977999 scopus 로고    scopus 로고
    • Human pharmacokinetic characterization and in vitro study of the interaction between doxorubicin and paclitaxel in patients with breast cancer
    • Gianni L, Vigan L, Locatelli A, et al. Human pharmacokinetic characterization and in vitro study of the interaction between doxorubicin and paclitaxel in patients with breast cancer. J Clin Oncol 2007; 15 (5): 1906-1915
    • (2007) J Clin Oncol , vol.15 , Issue.5 , pp. 1906-1915
    • Gianni, L.1    Vigan, L.2    Locatelli, A.3
  • 18
    • 0345230986 scopus 로고    scopus 로고
    • Pharmacokinetic optimization of treatment schedules for anthracyclines and paclitaxel in cancer patients
    • Danesi R, Conte PF, Del Tacca M. Pharmacokinetic optimization of treatment schedules for anthracyclines and paclitaxel in cancer patients. Clin Pharmacokinet 1999; 9: 135-211.
    • (1999) Clin Pharmacokinet , vol.9 , pp. 135-211
    • Danesi, R.1    Conte, P.F.2    Del Tacca, M.3
  • 19
    • 33846425322 scopus 로고    scopus 로고
    • Defective taxane stimulation of epirubicinol formation in the human heart: Insight into the cardiac tolerability of epirubicin-taxane chemotherapies
    • Salvatorelli E, Menna P, Gianni L, Minotti G. Defective taxane stimulation of epirubicinol formation in the human heart: insight into the cardiac tolerability of epirubicin-taxane chemotherapies. J Pharmacol Exp Ther 2007; 320(2): 790-800.
    • (2007) J Pharmacol Exp Ther , vol.320 , Issue.2 , pp. 790-800
    • Salvatorelli, E.1    Menna, P.2    Gianni, L.3    Minotti, G.4
  • 20
    • 34548276036 scopus 로고    scopus 로고
    • Molecularly targeted oncology therapeutics and prolongation of the QT interval
    • Strevel EL, Ing DJ, Siu L.L. Molecularly targeted oncology therapeutics and prolongation of the QT interval. J Clin Oncol 2007; 25: 3362-3371
    • (2007) J Clin Oncol , vol.25 , pp. 3362-3371
    • Strevel, E.L.1    Ing, D.J.2    Siu, L.L.3
  • 21
    • 55949123335 scopus 로고    scopus 로고
    • Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma
    • Schmidinger M, Zielinski CC, Vogl UM, et al. Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2008; 26(32): 5204-5212
    • (2008) J Clin Oncol , vol.26 , Issue.32 , pp. 5204-5212
    • Schmidinger, M.1    Zielinski, C.C.2    Vogl, U.M.3
  • 22
    • 66249118670 scopus 로고    scopus 로고
    • (ZD6474) a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions
    • Morabito A, Piccirillo MC, Falasconi F, et al. (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions. Oncologist 2009; 14(4): 378-390
    • (2009) Oncologist , vol.14 , Issue.4 , pp. 378-390
    • Morabito, A.1    Piccirillo, M.C.2    Falasconi, F.3
  • 23
    • 54349127397 scopus 로고    scopus 로고
    • Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells
    • Will Y, Dykens JA, Nadanaciva S, et al. Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells. Toxicol Sci 2008; 106(1): 153-161
    • (2008) Toxicol Sci , vol.106 , Issue.1 , pp. 153-161
    • Will, Y.1    Dykens, J.A.2    Nadanaciva, S.3
  • 24
    • 67649958842 scopus 로고    scopus 로고
    • Cardiovascular complications of cancer therapy: Incidence, pathogenesis, diagnosis and management
    • Yeh ETH, Bickford CL. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis and management. J Am Coll Cardiol 2009; 53: 2231-2247
    • (2009) J Am Coll Cardiol , vol.53 , pp. 2231-2247
    • Yeh, E.T.H.1    Bickford, C.L.2
  • 25
    • 35348851892 scopus 로고    scopus 로고
    • The acute effect of trastuzumab infusion on ECG parameters in metastatic breast cancer patients
    • Yavas O, Yazici M, Eren O, Oyan B. The acute effect of trastuzumab infusion on ECG parameters in metastatic breast cancer patients. Swiss Med Wkly 2007; 137(39-40): 556-558
    • (2007) Swiss Med Wkly , vol.137 , Issue.39-40 , pp. 556-558
    • Yavas, O.1    Yazici, M.2    Eren, O.3    Oyan, B.4
  • 26
    • 33847090759 scopus 로고    scopus 로고
    • Non-myopathic cardiac events in two patients treated with trastuzumab
    • Olin RL, Desai SS, Fox K, Davidson R. Non-myopathic cardiac events in two patients treated with trastuzumab. Breast J 2007; 13(2): 211-212
    • (2007) Breast J , vol.13 , Issue.2 , pp. 211-212
    • Olin, R.L.1    Desai, S.S.2    Fox, K.3    Davidson, R.4
  • 27
    • 61549132159 scopus 로고    scopus 로고
    • Genentech Inc. [online], Available from
    • Genentech Inc. Bevacizumab Prescribing Information [online]. 2008. Available from: http://www.gene.com/gene/products/information/pdf/avastin- prescribing.pdf.
    • (2008) Bevacizumab Prescribing Information
  • 28
    • 61549120823 scopus 로고    scopus 로고
    • Takotsubo cardiomyopathy in two men receiving bevacizumab for metastatic cancer
    • Franco TH, Khan A, Joshi V, Thomas B. Takotsubo cardiomyopathy in two men receiving bevacizumab for metastatic cancer. Ther Clin Risk Manag 2008; 4(6): 1367-1370
    • (2008) Ther Clin Risk Manag , vol.4 , Issue.6 , pp. 1367-1370
    • Franco, T.H.1    Khan, A.2    Joshi, V.3    Thomas, B.4
  • 29
    • 33745683507 scopus 로고    scopus 로고
    • Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma
    • Piekarz RL, Frye AR, Wright JJ, et al. Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma. Clin Cancer Res 2006; 12(12): 3762-3773
    • (2006) Clin Cancer Res , vol.12 , Issue.12 , pp. 3762-3773
    • Piekarz, R.L.1    Frye, A.R.2    Wright, J.J.3
  • 30
    • 34547683194 scopus 로고    scopus 로고
    • Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
    • Olsen E, Kim YH, Kuzel TM, et al. Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol 2007; 25(21): 3109-3115
    • (2007) J Clin Oncol , vol.25 , Issue.21 , pp. 3109-3115
    • Olsen, E.1    Kim, Y.H.2    Kuzel, T.M.3
  • 31
    • 38349187877 scopus 로고    scopus 로고
    • Clinically relevant QTc prolongation is not associated with current dose schedules of LBH589 (panobinostat)
    • Zhang L, Lebwohl D, Masson E, Laird G, Cooper MR, Prince HM. Clinically relevant QTc prolongation is not associated with current dose schedules of LBH589 (panobinostat). J Clin Oncol 2008; 26(2): 332-333
    • (2008) J Clin Oncol , vol.26 , Issue.2 , pp. 332-333
    • Zhang, L.1    Lebwohl, D.2    Masson, E.3    Laird, G.4    Cooper, M.R.5    Prince, H.M.6
  • 32
    • 54349129547 scopus 로고    scopus 로고
    • Autophagy induced by farnesyltransferase inhibitors in cancer cells
    • Pan J, Chen B, Su CH, et al. Autophagy induced by farnesyltransferase inhibitors in cancer cells. Cancer Biol Ther 2008; 7(10): 1679-1684
    • (2008) Cancer Biol Ther , vol.7 , Issue.10 , pp. 1679-1684
    • Pan, J.1    Chen, B.2    Su, C.H.3
  • 33
    • 65649130809 scopus 로고    scopus 로고
    • The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner
    • Zhou J, Vos CC, Gjyrezi A, et al. The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner. J Biol Chem 2009; 284 (15): 9648-9655
    • (2009) J Biol Chem , vol.284 , Issue.15 , pp. 9648-9655
    • Zhou, J.1    Vos, C.C.2    Gjyrezi, A.3
  • 34
    • 26444439758 scopus 로고    scopus 로고
    • A phase II study on lonafarnib(SCH66336) in patients with chemo-refractory advanced head and neck squamous cell carcinoma
    • abstract 5565
    • Yang CH, Kies MS, Glisson B. A phase II study on lonafarnib(SCH66336) in patients with chemo-refractory advanced head and neck squamous cell carcinoma. J Clin Oncol 2005; 23: 16S (abstract 5565).
    • (2005) J Clin Oncol , vol.23
    • Yang, C.H.1    Kies, M.S.2    Glisson, B.3
  • 35
    • 67749135818 scopus 로고    scopus 로고
    • A phase II study of lonafarnib (SCH66336) in patients with chemorefractory, advanced squamous cell carcinoma of the head and neck
    • Epub ahead of print
    • Hanrahan EO, Kies MS, Glisson BS, et al. A phase II study of lonafarnib (SCH66336) in patients with chemorefractory, advanced squamous cell carcinoma of the head and neck. Am J Clin Oncol 2009 [Epub ahead of print].
    • (2009) Am J Clin Oncol
    • Hanrahan, E.O.1    Kies, M.S.2    Glisson, B.S.3
  • 36
    • 53549126061 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitor (lonafarnib) in patients with myelodysplastic syndrome or secondary acute myeloid leukaemia: A phase II study
    • Ravoet C, Mineur P, Robin V, et al. Farnesyl transferase inhibitor (lonafarnib) in patients with myelodysplastic syndrome or secondary acute myeloid leukaemia: a phase II study. Ann Hematol 2008; 87(11): 881-885
    • (2008) Ann Hematol , vol.87 , Issue.11 , pp. 881-885
    • Ravoet, C.1    Mineur, P.2    Robin, V.3
  • 37
    • 66149183000 scopus 로고    scopus 로고
    • A phase i trial of enzastaurin in patients with recurrent gliomas
    • Kreisl TN, Kim L, Moore K, et al. A phase I trial of enzastaurin in patients with recurrent gliomas. Clin Cancer Res 2009; 15(10): 3617-3623
    • (2009) Clin Cancer Res , vol.15 , Issue.10 , pp. 3617-3623
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3
  • 38
    • 58349117702 scopus 로고    scopus 로고
    • Safety, tolerability, QTc evaluation, and pharmacokinetics of single and multiple doses of enzastaurin HCl (LY317615), a protein kinase C-beta inhibitor, in healthy subjects
    • Welch PA, Sinha VP, Cleverly AL, Darstein C, Flanagan SD, Musib LC. Safety, tolerability, QTc evaluation, and pharmacokinetics of single and multiple doses of enzastaurin HCl (LY317615), a protein kinase C-beta inhibitor, in healthy subjects. J Clin Pharmacol 2007; 47(9): 1138-1151
    • (2007) J Clin Pharmacol , vol.47 , Issue.9 , pp. 1138-1151
    • Welch, P.A.1    Sinha, V.P.2    Cleverly, A.L.3    Darstein, C.4    Flanagan, S.D.5    Musib, L.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.