Anatomical and functional correlates in major depressive disorder: The contribution of neuroimaging studies

World Journal of Biological Psychiatry

Volumn 11, Issue 2 PART 2, 2010, Pages 165-180

  Rigucci, Silvia ^a   Serafini, Gianluca ^a   Pompili, Maurizio ^a,b   Kotzalidis, Giorgio D ^a   Tatarelli, Roberto ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b MCLEAN HOSPITAL   (United States)

Author keywords

Antidepressants; Brain imaging; Major depressive disorder; PET; SPECT

Indexed keywords

HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; PAROXETINE; VENLAFAXINE;

BRAIN METABOLISM; BRAIN REGION; COGNITIVE THERAPY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MAJOR DEPRESSION; NERVE CELL NETWORK; NEUROANATOMY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANTIDEPRESSIVE AGENTS; BRAIN; DEPRESSIVE DISORDER, MAJOR; HUMANS; MAGNETIC RESONANCE IMAGING; MOOD DISORDERS; POSITRON-EMISSION TOMOGRAPHY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 77950807914     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622970903131571     Document Type: Review

References (100)

1. Abou-Saleh MT. 2006. Neuroimaging in psychiatry: An update. J Psychosom Res 61:289-293.
2. Alves TC, Rays J, Fráguas R Jr, Wajngarten M, Telles RM, Duran FL, et al. 2006. Association between major depressive symptoms in heart failure and impaired regional cerebral blood flow in the medial temporal region: a study using 99m Tc-HMPAO single photon emission computerized tomography (SPECT). Psychol Med 36:597-608.
3. Anand A, Charney DS. 2000. Norepinephrine dysfunction in depression. J Clin Psychiatry 61(Suppl):16-24.
4. Anand A, Li Y, Wang Y. 2005. Antidepressant effect on connectivity of the mood-regulating circuit: an fMRI study. Neuropsychopharmacology 30:1334-1344.
5. Anand A, Li Y, Wang Y, Wu J, Gao S, Bukhari L, et al. 2005. Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry 57:1079-1088.
6. Anand A, Li Y, Wang Y, Lowe MJ, Dzemidzic M. 2009. Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res 171:189-198.
7. Baxter LR Jr, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, et al. 1989. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry 46:243-250.
8. Belmaker RH, Agam G. 2008. Major depressive disorder. New Engl J Med 358:55-68.
9. Bench CJ, Friston KJ, Brown RG, Frackowiak RS, Dolan RJ. 1993. Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions. Psychol Med 23:579-590.
10. Bonne O, Louzoun Y, Aharon I, Krausz Y, Karger H, Lerer B, et al. 2003. Cerebral blood flow in depressed patients: a methodological comparison of statistical parametric mapping and region of interest analyses. Psychiatry Res 122:49-57.
11. Brody AL, Saxena S, Silverman DH, Alborzian S, Fairbanks L, Phelps ME, et al. 1999. Brain metabolic changes in major depressive disorder from pre-to post-treatment with paroxetine. Psychiatry Res 91:127-139.
12. Brody AL, Saxena S, Stoessel P, Gillies LA, Fairbanks LA, Alborzian S, et al. 2001a. Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings. Arch Gen Psychiatry 58:631-640.
13. Brody AL, Barsom MW, Bota RG, Saxena S. 2001b. Prefrontalsubcortical and limbic circuit mediation of major depressive disorder. Semin Clin Neuropsychiatry 6:102-112.
14. Buchsbaum MS, Wu J, Siegel BV, Hackett E, Trenary M, Abel L, et al. 1997. Effect of sertraline on regional metabolic rate in patients with affective disorder. Biol Psychiatry 41:15-22.
15. Coffey CE, Ratcliff G, Saxton JA, Bryan RN, Fried LP, Lucke JF. 2001. Cognitive correlates of human brain aging: a quantitative magnetic resonance imaging investigation. J Neuropsychiatry Clin Neurosci 13:471-485.
16. Davies J, Lloyd KR, Jones IK, Barnes A, Pilowsky LS. 2003. Changes in regional cerebral blood flow with venlafaxine in the treatment of major depression. Am J Psychiatry 160:374-376.
17. Detera-Wadleigh SD, Mcmahon FJ. 2004. Genetic association studies in mood disorders: issues and promise. Int Rev Psychiatry 16:301-310.
18. Drevets WC, Todd RD. 2005. Depression, mania and related disorders. In: Rubin E, Zorumski C, editors. Adult psychiatry. 2nd ed. Oxford: Blackwell Publishing.
19. Drevets WC, Videen TO, Price JL, Preskorn SH, Carmichael ST, Raichle ME. 1992. A functional anatomical study of unipolar depression. J Neurosci 12:3628-3641.
20. Drevets WC, Bogers W, Raichle ME. 2002. Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsychopharmacol 12:527-544.
21. Drevets WC, Thase ME, Moses-Kolko EL, Price J, Frank E, Kupfer DJ, et al. 2007. Serotonin-1A receptor imaging in recurrent depression: replication and literature review. Nucl Med Biol . 034:865-877.
22. Drevets WC, Price JL, Furey ML. 2008a. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct 213:93-118.
23. Drevets WC, Savitz J, Trimble M. 2008b. The subgenual anterior cingulate cortex in mood disorders. CNS Spectr 13:663-681.
24. Ebmeier KP. 2000. Mood and cerebral perfusion revisited. Behav Neurol 12:87-92.
25. Eker C, Gonul AS. 2009. Volumetric MRI studies of the hippocampus in major depressive disorder: Meanings of inconsistency and directions for future research. World J Biol Psychiatry 6:1-17.
26. Fitzgerald PB, Laird AR, Maller J, Daskalakis ZJ. 2008. A metaanalytic study of changes in brain activation in depression. Hum Brain Mapp 29:683-695.
27. Fountoulakis KN, Iacovides A, Karamouzis M, Gerasimou G, Grammatikos P, Fotiou F, et al. 2007. Is it possible to predict the long-term response to venlafaxine with the use of biological markers and psychophysiological methods? J Affect Disord 99:155-163.
28. Friston KJ, Frith CD, Liddle PF, Frackowiak RS. 1993. Functional connectivity: the principal-component analysis of large (PET) data sets. J Cereb Blood Flow Metab 13:5-14.
29. Fu CHY, Williams SCR, Cleare AJ. 2004. Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry 61:877-889.
30. Fujimoto T, Takeuchi K, Matsumoto T, Fujita S, Honda K, Higashi Y, et al. 2008. Metabolic changes in the brain of patients with late-onset major depression. Psychiatry Res 164:48-57.
31. Graff-Guerrero A, González-Olvera J, Mendoza-Espinosa Y, Vaugier V, García-Reyna JC. 2004. Correlation between cerebral blood flow and items of the Hamilton Rating Scale for Depression in antidepressant-naive patients. J Affect Disord 80:55-63.
32. Greenwald BS, Kramer-Ginsberg E, Bogerts B, Ashtari M, Aupperle P, Wu H, Allen L, et al. 1997. Qualitative magnetic resonance imaging findings in geriatric depression. Possible link between later-onset depression and Alzheimer's disease? Psychol Med 27:421-431.
33. Greicius MD, Krasnow B, Reiss AL. 2003. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 100:253-258.
34. Gonul AS, Kula M, Bilgin AG, Tutus A, Oguz A. 2004. The regional cerebral blood flow changes in major depressive disorder with and without psychotic features. Prog Neuropsychopharmacol Biol Psychiatry 28:1015-1021.
35. Goodwin GM, Austin MP, Dougall N, Ross M, Murray C, O'Carroll RE, et al. 1993. State changes in brain activity shown by the uptake of 99mTc-exametazime with single photon emission tomography in major depression before and after treatment. J Affect Disord 29:243-253.
36. Graff-Guerrero A, González-Olvera J, Mendoza-Espinosa Y, Vaugier V, García-Reyna JC. 2004. Correlation between cerebral blood flow and items of the Hamilton Rating Scale for Depression in antidepressant-naive patients 80:55-63.
37. Gusnard DA, Akbudak E, Shulman GL, Raichle ME. 2008. Medial prefrontal cortex and self-referential mental activity: relation to a Brain Struct Funct 213:93-118.
38. Halloran E, Prentice N, Murray CL, O'Carroll RE, Glabus MF, Goodwin GM, et al. 1999. Follow-up study of depression in the elderly. Clinical and SPECT data. Br J Psychiatry 175:252-258.
39. Hampson M, Peterson BS, Skudlarski P. 2002. Detection of functional connectivity using temporal correlations in MR images. Hum Brain Mapp 15:247-262.
40. Hasin DS, Goodwin RD, Stinson FS, Grant BF. 2005. Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Arch Gen Psychiatry 62:1097-1106.
41. Heinz A, Braus DF, Smolka MN. 2005. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 8:20-21.
42. Hickie I, Ward P, Scott E, Haindl W, Walker B, Dixon J, et al. 1999. Neo-striatal rCBF correlates of psychomotor slowing in patients with major depression. Psychiatry Res 92:75-81.
43. Holthoff VA, Beuthien-Baumann B, Zündorf G, Triemer A, Lüdecke S, Winiecki P, et al. 2004. Changes in brain metabolism associated with remission in unipolar major depression. Acta Psychiatr Scand 110:184-194.
44. Hornig M, Mozley PD, Amsterdam JD. 1997. HMPAO SPECT brain imaging in treatment-resistant depression. Prog Neuropsychopharmacol Biol Psychiatry 21:1097-1114.
45. Husain MM, McDonald WM, Doraiswamy PM, Figiel GS, Na C, Escalona PR, et al. 1991. A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Res 40: 95-99.
46. Ishizaki J, Yamamoto H, Takahashi T, Takeda M, Yano M, Mimura M. 2008. Changes in regional cerebral blood flow following antidepressant treatment in late-life depression. Int J Geriatr Psychiatry 23:805-811.
47. Joe AY, Tielmann T, Bucerius J, Reinhardt MJ, Palmedo H, Maier W, et al. 2006. Response-dependent differences in regional cerebral blood flow changes with citalopram in treatment of major depression. J Nucl Med 47:1319-1325.
48. Kennedy SH, Evans KR, Krü ger S, Mayberg HS, Meyer JH, McCann S, et al. 2001. Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. Am J Psychiatry 158:899-905.
49. Kennedy SH, Konarski JZ, Segal ZV, Lau MA, Bieling PJ, McIntyre RS, et al. 2007. Differences in brain glucose metabolism between responders to CBT and venlafaxine in a 16-week randomized controlled trial. Am J Psychiatry 164:778-788.
50. Kessing LV. 2007. Epidemiology of subtypes of depression. Acta Psychiatr Scand 115:85-89.
51. Kessing LV, Hansen HV, Bech P. 2006. Attitudes and beliefs among patients treated with mood stabilizers. Clin Pract Epidemol Ment Health 2:8.
52. Kim SJ, Song SH, Kim JH, Kwak IS. 2008. Statistical parametric mapping analysis of the relationship between regional cerebral blood flow and symptom clusters of the depressive mood in patients with pre-dialytic chronic kidney disease. Ann Nucl Med 22:201-206.
53. Kocmur M, Milcinski M, Budihna NV. 1998. Evaluation of brain perfusion with technetium-99m bicisate single-photon emission tomography in patients with depressive disorder before and after drug treatment. Eur J Nucl Med 25:1412-1414.
54. Kohn Y, Freedman N, Lester H, Krausz Y, Chisin R, Lerer B. et al. 2007. 99mTc-HMPAO SPECT study of cerebral perfusion after treatment with medication and electroconvulsive therapy in major depression. J Nucl Med 48:1273-1278.
55. Kohn Y, Freedman N, Lester H, Krausz Y, Chisin R, Lerer B. et al. 2008. Cerebral perfusion after a 2-year remission in major depression. Int J Neuropsychopharmacol 11:837-843.
56. Konarski JZ, McIntyre RS, Soczynska JK, Kennedy SH. 2007. Neuroimaging approaches in mood disorders: technique and clinical implications. Ann Clin Psychiatry 19:265-277.
57. Kondo H, Saleem KS, Price JL. 2005. Differential connections of the perirhinal and parahippocampal cortex with the orbital and medial prefrontal networks in macaque monkeys. J Comp Neurol 493:479-509.
58. Krishnan KR, Husain MM, McDonald WM, Doraiswamy PM, Figiel GS, Boyko OB, et al. 1990. In vivo stereological assessment of caudate volume in man: effect of normal aging. Life Sci 47:1325-1329.
59. Kronmü ller KT, Pantel J, Köhler S, Victor D, Giesel F, Magnotta VA., et al. 2008. Hippocampal volume and 2-year outcome in depression. Br J Psychiatry 192:472-473.
60. Kumar A, Bilker W, Jin Z., Udupa J. 2000. Atrophy and high intensity lesions: complementary neurobiological mechanisms in late-life major depression. Neuropsychopharmacology 22:264-274.
61. Lawrie SM, Buechel C, Whalley HC. 2002. Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol Psychiatry 51:1008-1011.
62. Liotti M, Mayberg HS, McGinnis S, Brannan SL, Jerabek P. 2002. Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depression. Am J Psychiatry 159:1830-1840.
63. Lorenzetti V, Allen NB, Fornito A, Yü cel M. 2009. Structural brain abnormalities in major depressive disorder: A selective review of recent MRI studies. J Affect Disord (Feb 22; Epub ahead of print).
64. Lowe MJ, Dzemidzic M, Lurito JT. 2000. Correlations in lowfrequency bold fluctuations reflect cortico-cortical connections. Neuroimage 12:582-587.
65. MacQueen GM, Yucel K, Taylor VH, Macdonald K, Joffe R. 2008. Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder. Biol Psychiatry 64:880-883.
66. Maldjian JA. 2001. Functional connectivity MR imaging: fact or artifact? Am J Neuroradiology 22:239-240.
67. Martin SD, Martin E, Rai SS, Richardson MA, Royall R. 2001. Brain blood flow changes in depressed patients treated with interpersonal psychotherapy or venlafaxine hydrochloride: preliminary findings. Arch Gen Psychiatry 58:641-648.
68. Mayberg HS, Brannan SK, Mahurin RK, Jerabek PA, Brickman JS, Tekell JL, et al. 1997. Cingulate function in depression: a potential predictor of treatment response. Neuroreport 8:1057-1061.
69. Mayberg HS, Brannan SK, Tekell JL, Silva JA, Mahurin RK, McGinnis S, et al. 2000. Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol Psychiatry 48:830-843.
70. Mayberg HS. 2003. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. Br Med Bull 65:193-207.
71. Mayberg HS, Silva JA, Brannan SK, Tekell JL, Mahurin RK, McGinnis S, et al. 2002. The functional neuroanatomy of the placebo effect. Am J Psychiatry 159:728-737.
72. Matthews SC, Strigo IA, Simmons AN, Yang TT, Paulus MP. 2008. Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder. J Affect Disord 111:13-20.
73. McKinnon MC, Yucel K, Nazarov A, MacQueen GM. 2009. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 34:41-54.
74. Meltzer CC, Price JC, Mathis CA, Butters MA, Ziolko SK, Moses-Kolko E, et al. 2004. Serotonin 1A receptor binding and treatment response in late-life depression. Neuropsychopharmacology 29:2258-2265.
75. Moresco RM, Colombo C, Fazio F, Bonfanti A, Lucignani G, Messa C, et al. 2000. Effects of fluvoxamine treatment on the in vivo binding of [F-18]FESP in drug naive depressed patients: a PET study. Neuroimage 12:452-465.
76. Navarro V, Gastó C, Lomeña F, Mateos JJ, Marcos T. 2001. Frontal cerebral perfusion dysfunction in elderly late-onset major depression assessed by 99MTC-HMPAO SPECT. Neuroimage 14:202-205.
77. Navarro V, Gastó C, Lomeña F, Mateos JJ, Marcos T, Portella MJ. 2002. Normalization of frontal cerebral perfusion in remitted elderly major depression: a 12-month follow-up SPECT study. Neuroimage 16:781-787.
78. Navarro V, Gastó C, Lomeña F, Torres X, Mateos JJ, Portella MJ, et al. 2004. Prognostic value of frontal functional neuroimaging in late-onset severe major depression. Br J Psychiatry 184:306-311.
79. Ongü r D, Ferry AT, Price JL. 2003. Architectonic subdivision of the human orbital and medial prefrontal cortex. J Comp Neurol 460:425-449.
80. Ogura A, Morinobu S, Kawakatsu S, Totsuka S, Komatani A. 1998. Changes in regional brain activity in major depression after successful treatment with antidepressant drugs. Acta Psychiatr Scand 98:54-59.
81. Pagani M, Gardner A, Salmaso D, Sánchez Crespo A, Jonsson C, Jacobsson H., et al. 2004. Principal component and volume of interest analyses in depressed patients imaged by 99mTc-HMPAO SPET: a methodological comparison. Eur J Nucl Med Mol Imaging 31:995-1004.
82. Parashos IA, Tupler LA, Blitchington T, Krishnan KR. 1998. Magnetic-resonance morphometry in patients with major depression. Psychiatry Res 84:7-15.
83. Pillay SS, Renshaw PF, Bonello CM, Lafer BC, Fava M, Yurgelun-Todd D. 1998. A quantitative magnetic resonance imaging study of caudate and lenticular nucleus gray matter volume in primary unipolar major depression: relationship to treatment response and clinical severity. Psychiatry Res 84: 61-74.
84. Rabins PV, Aylward E, Holroyd S, Pearlson G. 2000. MRI findings differentiate between late-onset schizophrenia and late-life mood disorder. Int J Geriatr Psychiatry 15:954-960.
85. Sackeim HA, Prohovnik I, Moeller JR, Brown RP, Apter Prudic J, et al. 1990. Regional cerebral blood flow in mood disorders. I. Comparison of major depressives and normal controls at rest. Arch Gen Psychiatry 47:60-70.
86. Saleem KS, Kondo H, Price JL. 2008. Complementary circuits connecting the orbital and medial prefrontal networks with the temporal, insular, and opercular cortex in the macaque monkey. J Comp Neurol 506:659-693.
87. Saxena S, Brody AL, Ho ML, Alborzian S, Maidment KM, Zohrabi N, et al. 2002. Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Arch Gen Psychiatry 59:250-261.
88. Sheline YI, Barch DM, Donnelly JM. 2001. Increased amygdale response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol Psychiatry 50:651-658.
89. Schlösser RG, Wagner G, Koch K, Dahnke R, Reichenbach JR, Sauer H. 2008. Fronto-cingulate effective connectivity in major depression: a study with fMRI and dynamic causal modeling. Neuroimage 43:645-655.
90. Schöning S, Zwitserlood P, Engelien A, Behnken A, Kugel H, Schiffbauer H, et al. 2008. Working-memory fMRI reveals cingulate hyperactivation in euthymic major depression. Hum Brain Mapp (Dec 11; Epub ahead of print).
91. Schweitzer I, Tuckwell V, Ames D, O'Brien J. 2001. Structural neuroimaging studies in late-life depression: a review. World J Biol Psychiatry 2:83-88.
92. Siegle GJ, Carter CS, Thase ME. 2006. Use ofFMRI to predict recovery from unipolar depression with cognitive behavior therapy. Am J Psychiatry 163:735-738.
93. Skaf CR, Yamada A, Garrido GE, Buchpiguel CA, Akamine S, Castro CC, et al. 2002. Psychotic symptoms in major depressive disorder are associated with reduced regional cerebral blood flow in the subgenual anterior cingulate cortex: a voxel-based single photon emission computed tomography (SPECT) study. J Affect Disord 68:295-305.
94. Smoski MJ, Felder J, Bizzell J, Green SR, Ernst M, Lynch TR Dichter GS. 2009. fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder. J Affect Disord (Mar 2; Epub ahead of print).
95. Sullivan PF, Neale MC, Kendler KS. 2000. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 157:1552-1562.
96. Vasic N, Walter H, Sambataro F, Wolf RC. 2008. Aberrant functional connectivity of dorsolateral prefrontal and cingulate networks in patients with major depression during working memory processing. Psychol Med 10:1-11.
97. Vlassenko A, Sheline YI, Fischer K, Mintun MA. 2004. Cerebral perfusion response to successful treatment of depression with different serotoninergic agents. J Neuropsychiatry Clin Neurosci 16:360-363.
98. Werner NS, Meindl T, Materne J, Engel RR, Huber D, Riedel M. et al. 2009. Functional MRI study of memory-related brain regions in patients with depressive disorder. J Affect Disord (Apr 3; Epub ahead of print).
99. WHO. 2001. The world health report (http://www.who.int; Chap 2,4).
100. Zipursky RB, Meyer JH, Verhoeff NP. 2007. PET and SPECT imaging in psychiatric disorders. Can J Psychiatry 52:146-157.